Journal
ALLERGY
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/all.15961
Keywords
allergy; anaphylaxis; drug hypersensitivity; hypersensitivity reaction; proton pump inhibitors
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This paper provides evidence-based recommendations for the diagnosis and management of hypersensitivity reactions (HSRs) to proton pump inhibitors (PPIs), and calls for further in-depth research.
Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well-known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%-3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence-based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in-depth investigations in the topic.
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