Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 11, Issue 1, Pages 142-148Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3qo00599b
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In this study, a direct electrolysis protocol was demonstrated for the chemo- and regio-selective difluorination, azo-fluorination, and fluoro-alkoxylation of gem-difluorostyrenes under mild conditions. The reaction allowed for the selective synthesis of a distinct type of long-chain perfluoroalkyl aromatics involving Et3N3HF as the fluorine source with/without other nucleophiles. The reaction exhibited good functional group tolerance and was amenable to gram-scale synthesis. Moreover, an electrochemical reduction of the benzyl C-F bond was also achieved.
Herein, a direct electrolysis protocol for the chemo- and regio-selective difluorination, azo-fluorination, and fluoro-alkoxylation of gem-difluorostyrenes under mild conditions is demonstrated. The reaction enables the selective synthesis of a distinct type of long-chain perfluoroalkyl aromatics involving Et3N3HF as the fluorine source with/without other nucleophiles. The reaction exhibits good functional group tolerance, and is amenable to gram-scale synthesis. Moreover, an electrochemical reduction of the benzyl C-F bond was also achieved.
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