☆ 4.6 Review

Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues

INFLAMMOPHARMACOLOGY (2023)

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Ligustilide modulates oxidative stress, apoptosis, and immunity to avoid pathological damages in bleomycin induced pulmonary fibrosis rats via inactivating TLR4/MyD88/NF-KB P65

Shu Luo et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Ticagrelor Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by the Inhibition of TGF-beta 1/Smad3 and PI3K/AKT/mTOR Pathways

Hanaa Wanas et al.

CURRENT MOLECULAR PHARMACOLOGY (2020)

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Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation

Ling Peng et al.

CELL DEATH & DISEASE (2020)

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NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways

Jaye M. Platnich et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

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The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation

Rhiannon Campden et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

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NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer

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BIOSCIENCE REPORTS (2019)

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The Hsp27-Mediated IkBα-NFκB Signaling Axis Promotes Radiation-Induced Lung Fibrosis

Jee-Youn Kim et al.

CLINICAL CANCER RESEARCH (2019)

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Diverse Pharmacological Activities and Potential Medicinal Benefits of Geniposide

Yan-Xi Zhou et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

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NOD-like receptor signaling in inflammation-associated cancers: From functions to targeted therapies

Peng Liu et al.

PHYTOMEDICINE (2019)

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MicroRNA Post-transcriptional Regulation of the NLRP3 Inflammasome in Immunopathologies

Gulcin Tezcan et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Structure, interactions and self-assembly of ASC-dependent inflammasomes

Eva de Alba

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Lycorine exerts antitumor activity against osteosarcoma cells in vitro and in vivo xenograft model through the JAK2/STAT3 pathway

Hongzhi Hu et al.

ONCOTARGETS AND THERAPY (2019)

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Structural Basis of IL-1 Family Cytokine Signaling

James K. Fields et al.

FRONTIERS IN IMMUNOLOGY (2019)

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CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine

Roberto S. Accolla et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

Christian Bailly

PHYTOMEDICINE (2019)

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Raltegravir Attenuates Experimental Pulmonary Fibrosis In Vitro and In Vivo

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FRONTIERS IN PHARMACOLOGY (2019)

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Fibrocytes and fibroblasts-Where are we now

Sy Giin Chong et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Neutralization of IL-18 by IL-18 binding protein ameliorates bleomycin-induced pulmonary fibrosis via inhibition of epithelial-mesenchymal transition

Li-Ming Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Intestinal fibrosis

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MOLECULAR ASPECTS OF MEDICINE (2019)

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YY1 mediates TGF-β1-induced EMT and pro-fibrogenesis in alveolar epithelial cells

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RESPIRATORY RESEARCH (2019)

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A pathologic two-way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity

Helen Warheit-Niemi et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2019)

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The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Interleukin-18: Biological properties and role in disease pathogenesis

Gilles Kaplanski

IMMUNOLOGICAL REVIEWS (2018)

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The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

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MATRIX BIOLOGY (2018)

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Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation

Yi Li et al.

MOLECULAR IMMUNOLOGY (2018)

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Targeting the NLRP3 inflammasome in inflammatory diseases

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NATURE REVIEWS DRUG DISCOVERY (2018)

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Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

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NATURE COMMUNICATIONS (2018)

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Extracellular ATP is a danger signal activating P2X7 Receptor in a LPS mediated inflammation (ARDS/ALI)

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Oncotarget (2018)

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Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition

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BMC PHARMACOLOGY & TOXICOLOGY (2018)

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TGF-β receptors: In and beyond TGF-β signaling

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CELLULAR SIGNALLING (2018)

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NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter

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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2018)

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NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

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NATURE COMMUNICATIONS (2018)

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The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis

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Purinergic receptors: new targets for the treatment of gout and fibrosis

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NLRP3 participates in the regulation of EMT in bleomycin-induced pulmonary fibrosis

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Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

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Gasdermins: Effectors of Pyroptosis

Stephen B. Kovacs et al.

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Astragaloside IV Improves Bleomycin-Induced Pulmonary Fibrosis in Rats by Attenuating Extracellular Matrix Deposition

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Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3 Inflammasome

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CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

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The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases

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CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression

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BIOFACTORS (2016)

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The killer protein Gasdermin D

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Interleukin-18 deficiency protects against renal interstitial fibrosis in aldosterone/salt-treated mice

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Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1/IL-1R1/MyD88/NF-B pathway

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NATURE REVIEWS NEPHROLOGY (2016)

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Mechanism and Regulation of NLRP3 Inflammasome Activation

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Pleural inhibition of the caspase-1/IL-1β pathway diminishes profibrotic lung toxicity of bleomycin

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Analysis of blood neutrophil elastase, glutathione levels and pathological findings in postoperative acute exacerbation of idiopathic pulmonary fibrosis associated with lung cancer: Two case reports

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MOLECULAR AND CLINICAL ONCOLOGY (2016)

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JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers

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CLINICAL AND TRANSLATIONAL MEDICINE (2016)

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NOD-LIKE RECEPTORS: VERSATILE CYTOSOLIC SENTINELS

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NLRP3 inflammasome and its inhibitors: a review

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Mechanisms and Functions of Inflammasomes

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CELL (2014)

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Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

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EUROPEAN RESPIRATORY JOURNAL (2014)

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FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

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Molecular mechanisms of epithelial-mesenchymal transition

Samy Lamouille et al.

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Activation of NLRP3 inflammasome by crystalline structures via cell surface contact

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Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice

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NLRC5, at the heart of antigen presentation

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Functions of NOD-like receptors in human diseases

Yifei Zhong et al.

FRONTIERS IN IMMUNOLOGY (2013)

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Activation and regulation of the inflammasomes

Eicke Latz et al.

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MEK-ERK Pathway Modulation Ameliorates Pulmonary Fibrosis Associated with Epidermal Growth Factor Receptor Activation

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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2012)

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Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation

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A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice

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EUROPEAN RESPIRATORY JOURNAL (2012)

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Activation of the NLRP3 Inflammasome by Group B Streptococci

Alessandro Costa et al.

JOURNAL OF IMMUNOLOGY (2012)

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NLRC5: a key regulator of MHC class I-dependent immune responses

Koichi S. Kobayashi et al.

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Leucine-rich repeat (LRR) proteins Integrators of pattern recognition and signaling in immunity

Aylwin Ng et al.

AUTOPHAGY (2011)

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Understanding the mechanism of IL-1β secretion

Gloria Lopez-Castejon et al.

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Sensing damage by the NLRP3 inflammasome

Jaklien C. Leemans et al.

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Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis

Nicolas Riteau et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

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Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis

Thomas H. Sisson et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

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Nod proteins link bacterial sensing and autophagy

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AUTOPHAGY (2010)

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The Inflammasomes

Kate Schroder et al.

CELL (2010)

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ATP and the pathogenesis of COPD

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Neuronal apoptosis inhibitory protein, NAIP, is an inhibitor of procaspase-9

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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

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Snail More than EMT

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CELL ADHESION & MIGRATION (2010)

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Disruption of Interleukin-1 Signaling Improves the Quality of Wound Healing

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AMERICAN JOURNAL OF PATHOLOGY (2009)

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Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

Pamela Gasse et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)

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Role of Proinflammatory Cytokines IL-18 and IL-1β in Bleomycin-Induced Lung Injury in Humans and Mice

Tomoaki Hoshino et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2009)

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Function of Nod-like receptors in microbial recognition and host defense

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IMMUNOLOGICAL REVIEWS (2009)

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Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

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JOURNAL OF IMMUNOLOGY (2009)

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IL-1R1/MyD88 Signaling Is Critical for Elastase-Induced Lung Inflammation and Emphysema

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JOURNAL OF IMMUNOLOGY (2009)

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Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling

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NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)

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SNAI transcription factors mediate epithelial-mesenchymal transition in lung fibrosis

A. Jayachandran et al.

THORAX (2009)

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Putting the kibosh on mitochondrial antiviral signaling

Robert P. Kruger

CELL (2008)

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The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

Alessandro Sorrentino et al.

NATURE CELL BIOLOGY (2008)

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The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences

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PLOS ONE (2008)

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NLRX1 is a regulator of mitochondrial antiviral immunity

Chris B. Moore et al.

NATURE (2008)

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IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

Pamela Gasse et al.

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TGF-β activates Erk MAP kinase signalling through direct phosphorylation of ShcA

Matt K. Lee et al.

EMBO JOURNAL (2007)

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Therapies for bleomycin induced lung fibrosis through regulation of TGF-β1 induced collagen gene expression

Kenneth R. Cutroneo et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2007)

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Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

Joseph A. Duncan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis

Felix Chua et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

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Unraveling signalling cascades for the Snail family of transcription factors

B De Craene et al.

CELLULAR SIGNALLING (2005)

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Interleukin-1β causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung

U Lappalainen et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2005)

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Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis

Y Kitasato et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2004)

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PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1

YT Wang et al.

INTERNATIONAL IMMUNOLOGY (2004)

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MAP kinase activation and apoptosis in lung tissues from patients with idiopathic pulmonary fibrosis

K Yoshida et al.

JOURNAL OF PATHOLOGY (2002)

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IAP suppression of apoptosis involves distinct mechanisms: The TAK1/JNK1 signaling cascade and caspase inhibition

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MOLECULAR AND CELLULAR BIOLOGY (2002)

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