A tuning fork-shaped bisbenzothiazole derivative as a pH-responsive digital fluorescent probe and its ex vivo evaluation

A new highly emissive pH-responsive near-IR active digital probe was designed and synthesized. The probe is based on a bisbenzothiazole motif with a highly vulnerable hydrogen unit attached in an intramolecular fashion. The probe produced a large Stokes shift which was observed to be highly pH dependent. The optical pH dependence can be used for sensing pH over a wide range.

Automated summary

A new highly emissive pH-responsive near-IR active digital probe with a large Stokes shift and pH-dependent properties was designed and synthesized, which can be widely used for pH sensing.