Related references
Note: Only part of the references are listed.
Review
Chemistry, Multidisciplinary
Parbeen Singh et al.
Summary: Microneedles (MN) technology combined with photoresponsive (PR) materials is a promising approach for precise and effective delivery of therapeutics with enhanced efficacy or synergistic effects. This review provides a systematic summary of the therapeutic applications of PRMNs in cancer therapy, wound healing, diabetes treatment, and diagnostics. Different approaches to activate and control the release of therapeutic agents from PRMNs are also discussed. Overall, PRMNs offer a powerful tool for stimuli-responsive controlled-release therapeutic delivery to treat various diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemical Research Methods
Junxia Wang et al.
Summary: This paper presents an overview of state-of-the-art microneedle-based detection and sensing systems. Firstly, the designs of microneedle devices based on extraction mechanisms are summarized, including different geometries and materials of microneedles. Secondly, the targets of equipment-assisted microneedle detections are discussed, revealing the current performance and potential scenarios of these microneedles. Thirdly, the trend towards highly integrated sensors is elaborated by emphasizing the sensing principles (colorimetric, fluorometric and electronic manner). Finally, the key challenges and future development perspectives are discussed.
Article
Materials Science, Multidisciplinary
Zhicheng Le et al.
Summary: Microneedles technology is an efficient and minimally invasive method for transdermal delivery of bioactive molecules, avoiding the use of hypodermic needles. It has expanded its applications to non-dermatological purposes and shown promise in biomolecular and cellular sampling for patient health monitoring and disease diagnosis. This review discusses the design principles of microneedles to overcome biological barriers and recent innovations in biomolecular and cellular sampling.
Article
Chemistry, Multidisciplinary
Antonios Keirouz et al.
Summary: Conductive polymeric microneedle arrays have the potential to be used as minimally invasive monitoring tools in biodevices and wearables. However, previous efforts on microneedle electrodes have been limited to metallic substrates, which lack biological stability and are costly to manufacture. In this study, additive manufacturing is used to fabricate acrylic-based microneedle devices, which are then coated with conductive polypyrrole and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) films. These entirely polymer-based microneedle arrays act as dry conductive electrodes without the need for a metallic seed layer. Two coating methods, in situ polymerization and drop casting, are utilized to achieve conductivity. The fabricated microneedles penetrate porcine skin grafts without compromising their conductivity or morphology, and the coatings demonstrate durability over multiple penetration cycles. The non-cytotoxic nature of the conductive microneedles is confirmed using human fibroblast cells. This fabrication strategy offers a promising approach to manufacturing polymer-based conductive microneedle surfaces for biosensing applications.
Article
Engineering, Biomedical
Jungho Lee et al.
Summary: In this study, a shelf-stable dissolving microneedle (MN) patch is developed to prevent rebleeding during an emergency treatment. A minimally invasive hemostatic drug delivery system is established using a peripheral MN (p-MN) patch that enables topical drug absorption in the damaged capillaries. The invasiveness of MNs is examined through histological examination and the skin penetration force is quantified to demonstrate the milder administration of the p-MN patch compared to conventional MN patches. Hemostatic performance is studied systematically and the superior performance of the p-MN patch is demonstrated in an in vivo rat model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Meirong Yin et al.
Summary: Androgenetic alopecia (AGA) is a common type of hair loss that affects both men and women, reducing quality of life and self-esteem. Current therapeutic formulations have limitations, so there is a need for a safe and effective treatment. A water-soluble microneedle (MN) patch with biodegradable minoxidil-loaded microspheres was developed to provide long-acting treatment with reduced administration frequency and increased patient compliance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Correction
Chemistry, Multidisciplinary
Qing Zhang et al.
Review
Pharmacology & Pharmacy
Ran Mo et al.
Summary: Cutaneous wound healing is a complex process, and modulating the wound microenvironment has become crucial for therapy. Microneedle (MN) array patches have emerged as a new type of wound dressing that enables non-invasive transdermal and precise medication delivery. These patches, combined with smart materials, can monitor wound site markers and release therapeutic molecules responsively to modulate the wound microenvironment.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Minhui Lu et al.
Summary: Detection of biomarkers associated with wound conditions provides in-depth healthcare information and benefits wound healing treatment.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Shizhou Wu et al.
Summary: In this study, a multifunctional hyaluronic acid methacrylate (HAMA)/carboxymethyl chitosan (CMCS) core-shell microneedle patch with sodium alginate as a moisture layer was developed to maintain moisture balance in diabetic wounds. The microneedles were held on the wound by a chitosan adhesive layer and had sufficient strength to penetrate the biofilm. S. aureus secreted hyaluronidase to degrade the HAMA shell and promote the release of graphene oxide, which exhibited strong antibacterial activity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Yasaman Ghiyasi et al.
Summary: Chronic wounds occur due to various reasons, including trauma, accidents, and diseases. Diabetes is a major cause of non-healing wounds, and the number of people with diabetes is increasing globally. Microneedles (MNs) offer a promising solution for the treatment of chronic wounds, as they provide an effective and non-invasive way to deliver drugs and accelerate the healing process.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Yajuan Su et al.
Summary: This study presents a near-infrared (NIR) light-responsive microneedle patch that can release antimicrobial peptide for the treatment of wound biofilms. The patch contains IR780 iodide as a photothermal conversion agent and molecularly engineered peptide W379 as an antimicrobial agent, loaded in dissolvable PVP microneedles and coated with a phase change material TD. When exposed to NIR light, the patch releases the antimicrobial peptide, showing high antibacterial efficacy in vitro. This microneedle system also demonstrates excellent antibiofilm activities in ex vivo and in vivo experiments and has the potential to deliver other antimicrobial agents.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Bingjie Wang et al.
Summary: A novel biodegradable microneedle patch (CuS/PAF-26 MN) was developed for treating deep cutaneous fungal infection (DCFI). CuS/PAF-26 MN consists of hyaluronic acid (HA) and copper sulfide nano-enzyme (CuS NE) and antimicrobial peptide (PAF-26), which can deliver CuS NE and PAF-26 simultaneously. CuS NE catalyzes hydrogen peroxide to generate reactive oxygen species (ROS), and PAF-26 disrupts the fungal cell membrane directly, resulting in strong antifungal activities without drug resistance. In a DCFI mouse model, CuS/PAF-26 MN exhibited significantly superior antifungal effect compared to traditional ointment, CuS MN, or PAF-26 MN. Therefore, CuS/PAF-26 MN shows promising application prospects for DCFI treatment.
Article
Multidisciplinary Sciences
Ying Zhang et al.
Summary: The authors developed a core-shell structured microneedle array patch with programmed functions to dynamically modulate the wound immune microenvironment according to different healing phases. This patch promotes scarless wound repair and inhibits the formation of hypertrophic scars.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Jie Yang et al.
Summary: Microneedle patches loaded with Yunnan Baiyao ((BY + EGF)@MN) were developed for hemorrhagic wound healing. The patches demonstrated rapid hemostasis and regenerative properties by releasing Yunnan Baiyao to promote platelet adhesion and activating coagulation system, as well as controlled release of epidermal growth factor for wound healing. In vivo experiments showed satisfactory hemostatic effect and enhanced wound healing process in rat models. These (BY + EGF)@MNs hold potential for diverse wound healing applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Erman Zhao et al.
Summary: Oxygen plays a crucial role in diabetic chronic wound healing, and oxygen-delivering systems have gained significant attention. This study proposes using an active Chlorella vulgaris (Cv)-loaded separable microneedle (MN) as a method for controlled oxygen delivery to promote wound healing. The Cv-loaded microneedles (CvMN) consist of a PVA substrate and GelMA tips encapsulating Cv, which produces oxygen through photosynthesis and releases it in a controlled manner. Both in vitro and in vivo results demonstrate that CvMN effectively promotes cell proliferation, migration, angiogenesis, and wound healing in diabetic mice. The continuous generation of dissolved oxygen in CvMN and the presence of antioxidative substances in Cv contribute to its remarkable therapeutic effect.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Bruno Miranda et al.
Summary: Hollow MicroNeedles (HMNs) technology overcomes challenges in interstitial fluid (ISF) extraction and analysis, integrating a plasmonic transducer in the inner cavity for biomarker detection at the point-of-care. The wearable HMN-based patch allows minimally invasive pierce of the skin and the large swelling capability of the transducer enables uptake of ISF by capillarity. Recognition of biotin, a small model molecule, is achieved through localized surface plasmon resonance and metal-enhanced fluorescence. This HMN-based patch represents a novel point-of-use device for biomarker detection in ISF, aiding faster medical decision-making.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Heng An et al.
Summary: There are challenges in treating deep burns, which include long recovery time, frequent dressing changes, wound infection, and scar formation. An ideal deep burn dressing should have good adhesion, painless replacement, resistance to infection, fast wound healing, reduced scarring, and easy monitoring. In this study, an anti-dehydration and rapid-trigger multifunctional hydrogel dressing was developed. The hydrogel showed strong interfacial adhesion and could decrease in the presence of glucose solution. It demonstrated excellent anti-dehydration, moisturizing, antibacterial properties, hemostasis, biocompatibility, and accelerated deep burn healing with reduced scars.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Yingjie Ren et al.
Summary: Microneedles, especially hollow microneedles (HMNs), are crucial for drug delivery. However, current HMNs are mainly manufactured using silicon microfabrication, which lacks a low-cost and batch-scale customized approach, especially for flexible substrate HMNs. This study proposes using a high-precision 3D printed master mold and a dual-molding process to prepare HMNs with different shapes and sizes. The reuse of the molds significantly reduces costs. The drug delivery efficiency of the fabricated HMNs was verified through in situ treatment of psoriasis in mice, which resulted in reduced side effects and drug toxicity. This dual-molding process can revitalize HMNs development.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Biao Wang et al.
Summary: In order to prevent the development of drug resistance during antibiotic treatment of wound infections, the use of antimicrobial peptides (AMPs) has been explored. However, challenges such as low bioavailability, rapid degradation of AMPs, and the difficulty of eliminating bacteria in deep tissue hinder its application. To address these issues, microneedle patches containing AMPs and recombinant type III humanized collagen (Col III) were designed for slow and controlled release to effectively eradicate bacteria in deep wound tissue and promote wound healing. This strategy demonstrates the potential of a microneedle-based antimicrobial drug delivery system.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Physical
Lin Chen et al.
Summary: A microneedle patch is designed to penetrate bacterial biofilms and deliver bacterial quorum sensing inhibitors and nanomotors with antibacterial properties. The results of in vitro and in vivo experiments show that the microneedle patches have good biosafety and antibacterial properties. The nanomotors, under near-infrared irradiation, can effectively remove biofilms and promote wound healing through photothermal and photodynamic therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Wenbin Shi et al.
Summary: A hydrogel with heat storage capacity and thermal conductivity was fabricated for burn therapy. By adding thermally conductive fillers, the hydrogel showed improved cooling performance and heat storage capacity. The hydrogel has great potential for practical applications.
Review
Chemistry, Multidisciplinary
Yue Zhao et al.
Summary: Tissue engineering offers a promising approach for treating organ or tissue loss, with supramolecular adhesive hydrogels showing great potential due to their unique properties. This review comprehensively summarizes the design principles and applications of adhesive hydrogels, highlighting their efficacy in various tissue repair processes.
Article
Engineering, Biomedical
Hongjian Zhang et al.
Summary: In this study, a bioactive nanofibrous scaffold incorporated with Zn2SiO4 nanoparticles is designed to promote innervated and vascularized skin burn wound healing. The scaffolds, with the release of bioactive Zn and Si ions, show excellent angiogenic and neurogenic activities, leading to rapid wound healing featured with newly formed blood vessels and nerve fibers.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Instruments & Instrumentation
Xiao Peng Zhang et al.
Summary: A new type of dissolving microneedle roller (DMNR) device was proposed for rapid drug delivery on large surface areas or curved skin. Experimental results showed that insulin-loaded DMNRs can quickly and effectively reduce blood glucose levels within 1 hour.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xiao-Xi Yang et al.
Summary: Hierarchically porous metal-organic framework (MOF)-based glucose-responsive microneedles (MNs) were developed for the treatment of infected diabetic wounds. The MOF can consume surplus glucose and generate antibacterial substances, showing satisfactory antibacterial activity.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Review
Engineering, Biomedical
Aryssa Simpson et al.
Summary: Uncontrolled bleeding is a significant issue in trauma and emergency medicine, and there is a need for easily deployable hemostatic materials in austere environments. This review provides an overview of materials used for topical hemostats and new advancements in injectable hemostats for emergency medicine.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Yan Deng et al.
Summary: An oriented antibacterial sericin microneedle (OASM) was designed for improved wound healing. The microneedles, inspired by lamprey teeth, provide both penetration and directional traction. Sericin, derived from silkworm cocoons, improves skin repair via hair follicle regeneration and angiogenesis. Additionally, zinc oxide nanoparticles enhance the antibacterial properties of the microneedles, showing promising clinical translational potential.
Article
Chemistry, Physical
Jiuyu Cui et al.
Summary: A Fe3O4-loaded photothermal microneedle patch (Fe3O4@MN) has been developed for controlled drug delivery, achieving enhanced drug release efficiency. The Fe3O4@MN has sufficient mechanical strength to penetrate the skin, and its temperature can rapidly increase under NIR irradiation. In vitro experiments showed high drug release rates and increased penetration depth compared to a patch without Fe3O4 nanoparticles, indicating the potential application of the synthesized microneedle patch for transdermal drug delivery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Heba Abd-El-Azim et al.
Summary: Photodynamic therapy (PDT) has emerged as a promising approach for managing non-melanoma skin cancers. In this study, Hy was successfully encapsulated into lipid nanocapsules (Hy-LNCs) and delivered intradermally using AdminPenTM hollow microneedles (Ho-MNs) array. The Hy-LNCs exhibited higher photoactivity, better skin penetration, and significantly enhanced therapeutic effect compared to free Hy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Ziad Sartawi et al.
Summary: This review discusses the recent developments and trends of dissolving microneedles as a drug delivery system, highlighting their advantages over coated and hollow microneedles. It emphasizes the potential applications of dissolving microneedles in various therapeutic areas and addresses current trends in the microneedle landscape, including clinical trials and commercial successes.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Bin Yang et al.
Summary: Researchers demonstrate an on-line wearable microneedle patch for real-time capture and monitoring of universal cell-free DNA.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Yuwen Lu et al.
Summary: This study fabricated stiff polymeric microneedles with backward-facing barbs inspired by honeybee stingers and embedded them into elastomer films to produce self-interlocking microneedle patches. The barbing pattern was adjusted to increase interlocking efficiency. The microneedle patches demonstrated strong tissue adhesion and were successfully implanted onto beating hearts. They reduced cardiac wall stress and maintained left ventricular function. The microneedle patches were minimally invasive and did not require sutures or adhesives.
ACTA BIOMATERIALIA
(2022)
Review
Materials Science, Biomaterials
Linyu Long et al.
Summary: This review summarizes the progress and research experience of multifunctional wound dressings in the treatment of chronic wounds in recent years, analyzes the functions of these dressings in anti-inflammatory, antioxidant, antibacterial, pro-angiogenic, and tissue adhesive, and discusses in detail the responsive mechanisms of smart multifunctional wound dressings.
BIOMATERIALS SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Jia-Hua Gong et al.
Summary: This study reports the preparation of Zn2GeO4:Cu2+ persistent luminescence nanorods and their application in treating MRSA-infected wounds. ZGC shows a long-persistent photocatalytic effect, continuously producing multiple ROS without the need for in situ excitation. ZGC@MNs patches exhibit excellent antibacterial activity and biocompatibility for promoting wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Tong Wu et al.
Summary: This biomimetic nanodrug delivery system targeting hypertrophic scar fibroblasts showed improved efficacy on hypertrophic scars by regulating specific pathways and reducing collagen expression. The combination of Bletilla striata polysaccharide (BSP) and dissolvable microneedles enhanced the mechanical strength and stability of the delivery system. This integrated drug delivery strategy holds promise for skin disease treatment and cosmetics applications.
Review
Biochemistry & Molecular Biology
Joseph G. Turner et al.
Summary: Hydrogel-forming microneedles offer enhanced transdermal drug delivery effectiveness and potential for passive extraction of interstitial fluid from the skin, making them suitable for biocompatible minimally invasive monitoring devices.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Multidisciplinary Sciences
Ester Caffarel-Salvador et al.
Summary: A highly drug-loaded microneedle patch was developed for rapid delivery of human insulin and growth hormone to the buccal cavity of swine, with the hard palate identified as the preferred application site. This study suggests that microneedle patches could increase medication adherence and provide painless delivery for pediatric and elderly populations.
Review
Biochemistry & Molecular Biology
Neha Dabholkar et al.
Summary: In recent years, there has been a surge in the use of transdermal drug delivery systems, with microneedles being a novel class of TDDS. Various polysaccharides and polypeptide based biomaterials are being used to fabricate biodegradable microneedles, showing promising advantages and applications in drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Alvaro Carcamo-Martinez et al.
Summary: Microneedles have the potential to be a highly progressive device for drug delivery and monitoring purposes by penetrating the skin and piercing the stratum corneum barrier. Hollow microneedles have entered the pharmaceutical market as medical devices, with continuous development in materials and methods for fabrication, and expanding applications in drug delivery, vaccine delivery, and monitoring.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biotechnology & Applied Microbiology
Wentao Shu et al.
Summary: Burn treatment is a challenging clinical issue with the future lying in the development of active dressings such as hydrogel dressings that can accelerate wound healing. Various treatment strategies for burns are reviewed, emphasizing the clinical value of hydrogel dressings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Yajuan Su et al.
Summary: Biofilms are a challenge to control wound infections, but a biphasic scaffold incorporating nanofiber mats and dissolvable microneedle arrays enables effective treatment by delivering multiple antimicrobial agents for eradicating bacterial biofilms without surgical debridement.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Yongping Liang et al.
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Chemistry, Multidisciplinary
Maoze Guo et al.
Summary: Intelligent wound management beyond therapeutic drug treatment shows potential in promoting recovery from chronic wounds. A shark tooth-inspired microneedle patch was developed using biomimetic structures for stable adhesion, controlled drug release, and analysis of inflammatory factors, as well as sensitive motion monitoring with MXene electronics, demonstrating improved recovery for full-thickness cutaneous wounds.
Review
Pharmacology & Pharmacy
Sophia N. Economidou et al.
Summary: This review identified key progress points in using 3D printing to manufacture microneedles over the past 3 years, particularly focusing on advances in photopolymerization and extrusion-based 3D printing. The study highlighted that printing resolution and material properties are the two critical parameters that significantly influence the outcome of microneedle printing endeavors. Finally, the authors attempted to estimate the impact of 3D printing on the transdermal drug delivery market.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Jia Heng Teoh et al.
Summary: Personalized medicine and care for burn victims are vital, and 3D printing technology shows potential in fabricating customizable wound dressings. The investigation of chitosan methacrylate as a material for 3D printing wound dressings is important, as it shows good wound healing properties and antimicrobial capabilities.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Xiaoxuan Zhang et al.
Summary: The study introduces a pagoda-like multilayer microneedle patch inspired by the hierarchical microstructure of insects, which can achieve rapid hemostasis and repair tissue injuries effectively. Its flexibility and efficiency make it a promising tool for various biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Lijing Zhang et al.
Summary: Transdermal preparations, especially dissolving microneedles, have gained significant attention in recent years due to their painless, safe, efficient delivery and easy operation. This article reviews the preparation methods, matrix polymer materials, performance testing, and applications of dissolving microneedles, aiming to provide a solid knowledge foundation for further research in this field.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Biomedical
Ning Tang et al.
Summary: Smart wound dressings integrated with multifunctional materials, wearable sensors, and drug delivery systems can monitor wounds and provide timely diagnosis and treatment, but there are still challenges to be addressed in their development and application.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Biomedical
Mojtaba Farahani et al.
Summary: The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden. The recent advances in materials and fabrication technologies have led to the development of smart wound dressings, such as 3D-printed dressings and biomolecule-loaded dressings, which accelerate wound healing and provide effective wound care management strategies.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Biomedical
Yong Kiel Sung et al.
Summary: The development of medical hemostatic biological materials is crucial for preventing intravascular bleeding, but separation of blood clots from blood vessel walls can cause serious health issues. Current research focuses on cellulose-based hemostatic starch, polysaccharide hemostatic materials, biomimetic adhesive chitosan, and gelatin-microbial transglutaminase-based hemostatic agents, aiming to find the optimal system to promote and strengthen active platelet aggregation in bleeding sites, increase thrombin production, and amplify hemostasis through a strengthened fibrin biopolymer network.
BIOMATERIALS RESEARCH
(2021)
Article
Emergency Medicine
Yunxia Chen et al.
Summary: The study showed that wound-healing rate, re-epithelialization, formation of granulation tissue, and inflammatory infiltration were greater in the Cut group compared to the SDDS and TDS groups. The number of blood vessels reached a peak in the Cut group, and the healing quality of the SDDS group was better compared to the Cut and TDS groups.
Article
Multidisciplinary Sciences
Guojun Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Medicine, General & Internal
Rezvan Jamaledin et al.
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Yongping Liang et al.
Article
Medicine, General & Internal
Marc G. Jeschke et al.
NATURE REVIEWS DISEASE PRIMERS
(2020)
Review
Chemistry, Multidisciplinary
Rezvan Jamaledin et al.
ADVANCED MATERIALS
(2020)
Article
Critical Care Medicine
Judith C. J. Holzer et al.
Article
Chemistry, Multidisciplinary
Yajuan Su et al.
Article
Engineering, Biomedical
Tikai Zhang et al.
ACTA BIOMATERIALIA
(2020)
Article
Medicine, Research & Experimental
Akmal Sabri et al.
MOLECULAR PHARMACEUTICS
(2020)
Review
Pharmacology & Pharmacy
Khater Ahmed Saeed AL-Japairai et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Chemistry, Multidisciplinary
Yi Zeng et al.
Review
Multidisciplinary Sciences
Xiaoxuan Zhang et al.
Article
Multidisciplinary Sciences
Mao Yokoyama et al.
SCIENTIFIC REPORTS
(2020)
Article
Automation & Control Systems
S. Pradeep Narayanan et al.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2019)
Article
Anatomy & Morphology
Mathilde Roger et al.
JOURNAL OF ANATOMY
(2019)
Review
Biotechnology & Applied Microbiology
Jason Heikenfeld et al.
NATURE BIOTECHNOLOGY
(2019)
Editorial Material
Engineering, Biomedical
Ryan F. Donnelly et al.
NATURE BIOMEDICAL ENGINEERING
(2019)
Article
Multidisciplinary Sciences
S. O. Blacklow et al.
Review
Polymer Science
Rushikesh S. Ambekar et al.
EUROPEAN POLYMER JOURNAL
(2019)
Article
Nanoscience & Nanotechnology
Yan Li et al.
MICROSYSTEMS & NANOENGINEERING
(2019)
Review
Chemistry, Multidisciplinary
Yoav Y. Broza et al.
Article
Nanoscience & Nanotechnology
Fanmao Liu et al.
ACS APPLIED MATERIALS & INTERFACES
(2019)
Review
Medicine, Research & Experimental
Tejashree Waghule et al.
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Review
Infectious Diseases
Silvano Esposito et al.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2019)
Article
Nanoscience & Nanotechnology
Bo Zhi Chen et al.
ACS APPLIED BIO MATERIALS
(2019)
Review
Dermatology
Franziska Rademacher et al.
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Cassie L. Caudill et al.
JOURNAL OF CONTROLLED RELEASE
(2018)
Review
Chemistry, Multidisciplinary
Alexey S. Rzhevskiy et al.
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Engineering, Electrical & Electronic
Richa Mishra et al.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2018)
Review
Immunology
Stefanie Eyerich et al.
TRENDS IN IMMUNOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Nak Won Kim et al.
Correction
Chemistry, Multidisciplinary
DaShawn A. Hickman et al.
ADVANCED MATERIALS
(2018)
Review
Chemistry, Multidisciplinary
Xiang Chen et al.
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Multidisciplinary Sciences
Gaozhi Chen et al.
Review
Biotechnology & Applied Microbiology
Hossein Derakhshandeh et al.
TRENDS IN BIOTECHNOLOGY
(2018)
Review
Infectious Diseases
Bilal Aslam et al.
INFECTION AND DRUG RESISTANCE
(2018)
Article
Multidisciplinary Sciences
Junnan Tang et al.
Article
Biology
Philip R. Miller et al.
COMMUNICATIONS BIOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Xi Xie et al.
Article
Chemistry, Physical
Mikyung Shin et al.
Review
Pharmacology & Pharmacy
S. Muench et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2017)
Article
Nanoscience & Nanotechnology
Boonnada Pamornpathomkul et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Article
Chemistry, Multidisciplinary
Akhilesh Kumar Shakya et al.
JOURNAL OF CONTROLLED RELEASE
(2017)
Review
Chemistry, Multidisciplinary
Guojun Ma et al.
JOURNAL OF CONTROLLED RELEASE
(2017)
Review
Biochemical Research Methods
Min Wang et al.
Article
Chemistry, Multidisciplinary
Qiu Yu Li et al.
Article
Chemistry, Medicinal
Emrullah Korkmaz et al.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2016)
Article
Medicine, General & Internal
C. Michael Gibson et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2016)
Article
Critical Care Medicine
Sayaka Ono et al.
Review
Pharmacology & Pharmacy
Song Xie et al.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2015)
Review
Engineering, Biomedical
Letizia Ventrelli et al.
ADVANCED HEALTHCARE MATERIALS
(2015)
Review
Pharmacology & Pharmacy
Kevin Ita
Article
Engineering, Biomedical
A. M. Romgens et al.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2014)
Review
Multidisciplinary Sciences
Bryan K. Sun et al.
Review
Pharmacology & Pharmacy
Yeu-Chun Kim et al.
ADVANCED DRUG DELIVERY REVIEWS
(2012)
Review
Polymer Science
A. P. Duarte et al.
PROGRESS IN POLYMER SCIENCE
(2012)
Article
Dermatology
Melissa L. Fernandez et al.
INTERNATIONAL WOUND JOURNAL
(2012)
Article
Engineering, Biomedical
Jyoti Gupta et al.
Review
Multidisciplinary Sciences
Geoffrey C. Gurtner et al.
Review
Biotechnology & Applied Microbiology
Mark R. Prausnitz et al.
NATURE BIOTECHNOLOGY
(2008)
Article
Chemistry, Multidisciplinary
Harvinder S. Gill et al.
JOURNAL OF CONTROLLED RELEASE
(2007)
Article
Hematology
A Pathak et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2006)
Article
Chemistry, Multidisciplinary
JH Park et al.
JOURNAL OF CONTROLLED RELEASE
(2005)
Review
Pharmacology & Pharmacy
MR Prausnitz
ADVANCED DRUG DELIVERY REVIEWS
(2004)
Article
Engineering, Electrical & Electronic
E Mukerjee et al.
SENSORS AND ACTUATORS A-PHYSICAL
(2004)
Article
Biophysics
SP Davis et al.
JOURNAL OF BIOMECHANICS
(2004)
