4.7 Article

Convergent insulin and TGF-β signalling drives cancer cachexia by promoting aberrant fat body ECM accumulation in a Drosophila tumour model

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy

Flavia A. Graca et al.

Summary: Myofiber atrophy is a key feature of cancer-induced wasting, and the muscle-secreted factor Fibcd1 plays an important role in maintaining myofiber size and mitigating atrophy induced by cachexia.

NATURE COMMUNICATIONS (2022)

Article Biochemical Research Methods

Analyzing cachectic phenotypes in the muscle and fat body of Drosophila larvae

Callum Dark et al.

Summary: This article presents a protocol for quick and consistent scoring of muscle detachment, fat body lipid droplet size, and extracellular matrix (ECM) quantifications in Drosophila larvae.

STAR PROTOCOLS (2022)

Review Entomology

Drosophila insulin-like peptides: from expression to functions - a review

Uliana Semaniuk et al.

Summary: Insulin-like peptides (ILPs) are important in fruit flies, activating intracellular proteins to participate in various functions such as physiological regulation and growth. Recent research focuses on the structure of ILPs, as well as how environmental factors and genetic manipulations affect their function, and their association with lifespan and metabolism in fruit flies.

ENTOMOLOGIA EXPERIMENTALIS ET APPLICATA (2021)

Article Cell Biology

An Oatp transporter-mediated steroid sink promotes tumor-induced cachexia in Drosophila

Paula Santabarbara-Ruiz et al.

Summary: The study showed that tumor-induced steroid sink promotes catabolic alterations in healthy tissues, and Oatp33Eb is specifically induced in cachectic tumors, where its overexpression causes cachexia.

DEVELOPMENTAL CELL (2021)

Article Genetics & Heredity

BMP pathway regulation of insulin signaling components promotes lipid storage in Caenorhabditis elegans

James F. Clark et al.

Summary: The study explores the interaction between the BMP and IIS pathways in lipid homeostasis, with INS-4 and DAF-16/FoxO playing key roles. Additionally, BMP activity alters the sensitivity of these transcription factors to IIS signaling, providing new insights into signaling crosstalk mechanisms and potential therapeutic targets.

PLOS GENETICS (2021)

Article Geriatrics & Gerontology

Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting

Jie Dong et al.

Summary: This study demonstrates a significant correlation between serum IGFBP2 levels, malnutrition, and muscle atrophy in PDAC. The results suggest that serum IGFBP2 level might serve as a promising biomarker and intervention target for severe malnutrition and muscle wasting associated with PDAC.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

Article Cell Biology

Tumor-derived MMPs regulate cachexia in a Drosophila cancer model

William Lodge et al.

Summary: The study established a Drosophila larval model where tumor-secreted Mmp1 was identified as a central mediator of organ wasting in cancer cachexia. Inhibition of TGF beta signaling or Mmp in the fat body/muscle rescued muscle wasting in the presence of tumor.

DEVELOPMENTAL CELL (2021)

Article Biochemistry & Molecular Biology

Host autophagy mediates organ wasting and nutrient mobilization for tumor growth

Rojyar Khezri et al.

Summary: In addition to supporting tumor metabolism and growth, autophagy plays a critical role in mediating systemic organ wasting and nutrient mobilization for tumor growth. The study demonstrates that autophagy mediates muscle atrophy and weight loss, leading to the release of amino acids and sugars into circulation for tumor growth.

EMBO JOURNAL (2021)

Article Biochemistry & Molecular Biology

Drosophila Larval Models of Invasive Tumorigenesis for In Vivo Studies on Tumour/Peripheral Host Tissue Interactions during Cancer Cachexia

Joseph A. Hodgson et al.

Summary: Research has found that cancer cachexia is dependent on the genetic characteristics of the tumour, and that host malnutrition or tumour burden alone are not enough to drive cachectic tissue wasting. Elevated JAK/STAT and TNF-alpha/Egr signaling in cachectic muscle promote tissue wasting. The introduction of a dual driver system allows for independent genetic manipulation of tumour and host skeletal muscle.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless

Jiae Lee et al.

Summary: The study demonstrates that tumors up-regulate Wingless to counteract the growth-impeding effects caused by ImpL2, allowing them to sustain growth during cachexia-like wasting. Moreover, targeting the Wnt/Wg pathway may be an efficient treatment strategy for cancers with elevated IGFBPs.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Cell Biology

Coordination of tumor growth and host wasting by tumor-derived Upd3

Guangming Ding et al.

Summary: The study using Drosophila model found that yki-induced gut tumors can cause host muscle dysfunction, lipid loss, and hyperglycemia, reminiscent of human cancer cachexia. By analyzing major signaling pathways and identifying the key role of the Upd3/Jak/Stat axis, the research revealed that yki-gut tumors secrete Upd3 to promote self-overproliferation and affect signaling in host organs, leading to wasting symptoms.

CELL REPORTS (2021)

Article Multidisciplinary Sciences

Systemic muscle wasting and coordinated tumour response drive tumourigenesis

Holly Newton et al.

NATURE COMMUNICATIONS (2020)

Article Genetics & Heredity

Age-Dependent Changes in Transcription Factor FOXO Targeting in Female Drosophila

Allison Birnbaum et al.

FRONTIERS IN GENETICS (2019)

Article Medicine, General & Internal

Cancer-associated cachexia

Vickie E. Baracos et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Article Biochemistry & Molecular Biology

Inter-adipocyte Adhesion and Signaling by Collagen IV Intercellular Concentrations in Drosophila

Jianli Dai et al.

CURRENT BIOLOGY (2017)

Article Oncology

Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway

Michele Joana Alves et al.

BMC CANCER (2017)

Article Multidisciplinary Sciences

Drosophila Dullard functions as a Mad phosphatase to terminate BMP signaling

Hugo Urrutia et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

High fat diet-induced TGF-β/Gbb signaling provokes insulin resistance through the tribbles expression

Seung-Hyun Hong et al.

SCIENTIFIC REPORTS (2016)

Article Cell Biology

Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting

Alejandra Figueroa-Clarevega et al.

DEVELOPMENTAL CELL (2015)

Article Cell Biology

Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis

Veronique Van de Bor et al.

CELL REPORTS (2015)

Article Biochemistry & Molecular Biology

Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie

Joseph Parker et al.

PLOS BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

Article Multidisciplinary Sciences

R-Smad Competition Controls Activin Receptor Output in Drosophila

Aidan J. Peterson et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila

Louise Y. Cheng et al.

Article Cell Biology

Shaping Cells and Organs in Drosophila by Opposing Roles of Fat Body-Secreted Collagen IV and Perlecan

Jose Carlos Pastor-Pareja et al.

DEVELOPMENTAL CELL (2011)

Article Multidisciplinary Sciences

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

Suman K. Das et al.

SCIENCE (2011)

Article Developmental Biology

Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila

Shannon L. Ballard et al.

DEVELOPMENTAL BIOLOGY (2010)

Article Cell Biology

Prothoracicotropic hormone regulates developmental timing and body size in Drosophila

Zofeyah McBrayer et al.

DEVELOPMENTAL CELL (2007)

Article Biochemistry & Molecular Biology

Distinct signaling of drosophila Activin/TGF-β family members

Scott C. Gesualdi et al.

Review Biochemistry & Molecular Biology

Role of insulin-like signalling in Drosophila lifespan

Maria E. Giannakou et al.

TRENDS IN BIOCHEMICAL SCIENCES (2007)

Article Genetics & Heredity

Drosophila target of rapamycin kinase functions as a multimer

Y Zhang et al.

GENETICS (2006)

Article Multidisciplinary Sciences

Antagonistic actions of ecdysone and insulins determine final size in Drosophila

J Colombani et al.

SCIENCE (2005)

Article Developmental Biology

Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo

E Eivers et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2004)

Article Cell Biology

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

HB Zhang et al.

GENES & DEVELOPMENT (2000)