The differences and overlaps between 'explanatory' and 'pragmatic' controlled trials: a historical perspective

Article Medicine, General & Internal

Trial analysis by treatment allocated or by treatment received? Origins of 'the intention-to-treat principle' to reduce allocation bias: part 2

I Chalmers et al.

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE (2023)

Review Anesthesiology

Prehabilitation in adult patients undergoing surgery: an umbrella review of systematic reviews

Daniel I. McIsaac et al.

Summary: This umbrella review investigated the impact of prehabilitation on postoperative outcomes and found that it may improve functional recovery and reduce the risk of complications, non-home discharge, and length of stay. However, the certainty of the existing evidence is low, and more high-quality research is needed to support these findings.

BRITISH JOURNAL OF ANAESTHESIA (2022)

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Article Health Care Sciences & Services

An analysis of published trials found that current use of pragmatic trial labels is uninformative

Monica Taljaard et al.

Summary: This study reviewed trial reports labeled as pragmatic, finding that the current use of pragmatic labels is unclear. Most reports referenced only one or two design elements, and some characteristics mentioned in the reports do not match the criteria for pragmatic trials. The authors suggest that authors should clarify the decision that the trial aims to support and include a PRECIS-2 table to improve transparency in trial design.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2022)

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Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

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Editorial Material Medicine, General & Internal