Evaluation of HbA1c from CGM traces in an Indian population

Article Endocrinology & Metabolism

Discordance Between Glucose Management Indicator and Glycated Hemoglobin in People Without Diabetes

Viral N. Shah et al.

Summary: The use of continuous glucose monitor (CGM) is increasing in healthy individuals without diabetes. However, there is a discrepancy between glucose management indicator (GMI) and glycated hemoglobin (HbA1c) in this population.

DIABETES TECHNOLOGY & THERAPEUTICS (2023)

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Article Endocrinology & Metabolism

Assessment of the Glucose Management Indicator Using Different Sampling Durations

Ryan Bailey et al.

Summary: By comparing the glucose management indicator (GMI) calculated using different durations of data, it was found that there was minimal difference between GMI computed with 7 days and 14 days of data. For most patients, satisfactory estimation of HbA1c can be obtained with 7 days of data.

DIABETES TECHNOLOGY & THERAPEUTICS (2023)

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Article Endocrinology & Metabolism

HbA1c and Glucose Management Indicator Discordance: A Real-World Analysis

Jordan E. Perlman et al.

Summary: This study retrospectively reviewed patient encounters and found significant discordance between laboratory-measured HbA1c and CGM-estimated eA1C. Majority of patients had type 1 diabetes, with an average CGM wear duration of 24.5 days. 50% of patients had HbA1c-GMI discordance of >= 0.5%, indicating clinicians need to be aware that HbA1c may not accurately reflect mean glucose levels as previously thought.

DIABETES TECHNOLOGY & THERAPEUTICS (2021)

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Article Biology

Addressing shortfalls of laboratory HbA1c using a model that incorporates red cell lifespan

Yongjin Xu et al.

Summary: The study suggests that laboratory HbA(1c) may not effectively predict diabetes complications, with clinically relevant differences observed compared to adjusted HbA(1c). This discrepancy could potentially have future clinical implications.

ELIFE (2021)

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Article Endocrinology & Metabolism

A Kinetic Model for Glucose Levels and Hemoglobin A1c Provides a Novel Tool for Individualized Diabetes Management

Yongjin Xu et al.

Summary: This study developed a kinetic model to create a novel glycemic marker, cHbA1c, which accurately estimates laboratory HbA1c. The model demonstrated a non-linear relationship between laboratory HbA1c and steady-state glucose, as well as modulation of glycation status by age. The new glycemic marker not only accurately reflects laboratory HbA1c, but also provides insights into the mechanisms for the mismatch between HbA1c and average glucose, with implications for future clinical management.

JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY (2021)

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Article Biochemical Research Methods