4.4 Article

Pharmacokinetics of Two Nanoemulsion Formulations of Δ8-Tetrahydrocannabinol in Rats

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

An update of nano-based drug delivery systems for cannabinoids: Biopharmaceutical aspects & therapeutic applications

Elisa Regina Lazzarotto Rebelatto et al.

Summary: Nanotechnology has been widely utilized to enhance the stability, potency, release control, and biopharmaceutical aspects of natural and synthetic cannabinoids. Different types of nanoparticle systems, such as lipid-based and polymer-based carriers, have been studied and analyzed for their advantages and disadvantages. Promising systems have been identified for targeted applications, facilitating the optimization of new formulations and providing potential benefits for the treatment of challenging diseases.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

Review Chemistry, Medicinal

Nanoformulations as a strategy to overcome the delivery limitations of cannabinoids

T. Srinivasa Reddy et al.

Summary: Medical cannabis has gained significant attention for its potential benefits in managing pain, anxiety, depression, and neurological disorders. The major phytocannabinoids derived from the cannabis plant, THC and CBD, have shown pharmacological and therapeutic properties. In particular, they have been studied for their use in cancer treatment due to their palliative effects and anticancer activities. However, their poor solubility and bioavailability limit their clinical application, thus nanotechnology-based drug delivery strategies are being developed to improve their efficacy.

PHYTOTHERAPY RESEARCH (2023)

Article Medicine, General & Internal

Assessment of Orally Administered?9-Tetrahydrocannabinol When Coadministered With Cannabidiol on?9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial

C. Austin Zamarripa et al.

Summary: This study compared the pharmacokinetics and pharmacodynamics of orally administered ?9-THC-dominant and CBD-dominant cannabis extracts at the same dose of ?9-THC (20 mg). The results showed that the use of CBD-dominant extract resulted in stronger adverse effects, contradicting the common claim that CBD attenuates the adverse effects of ?9-THC. These differences are likely due to the inhibition of ?9-THC and 11-OH-?9-THC metabolism by CBD. This study is important for understanding the clinical and regulatory decisions regarding the use of cannabis products and the interactions between cannabinoid compounds and drugs.

JAMA NETWORK OPEN (2023)

Review Chemistry, Medicinal

Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Elham Assadpour et al.

Summary: Researchers have developed nanocarriers to enhance the oral bioavailability of Cannabidiol (CBD), improving its therapeutic efficacy and ability to treat various diseases.

PHARMACEUTICALS (2023)

Article Pharmacology & Pharmacy

Development and pharmacokinetic evaluation of a self-nanoemulsifying drug delivery system for the oral delivery of cannabidiol

Lie Yun Kok et al.

Summary: The number of lipophilic drug candidates in pharmaceutical discovery pipelines has increased, leading to the need for improved formulation strategies. In this study, self-nanoemulsifying drug delivery systems (SNEDDS) were used to enhance the oral bioavailability of cannabidiol (CBD). The results showed that the SNEDDS formulations led to more rapid absorption and improved systemic exposure of CBD compared to traditional oil-based formulations.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Article Substance Abuse

Public interest in Δ8-Tetrahydrocannabinol (delta-8-THC) increased in US states that restricted Δ9-Tetrahydrocannabinol (delta-9-THC) use

Eric C. Leas et al.

Summary: Public interest in Delta-8-THC has rapidly increased, especially in US states that restrict Delta-9-THC use.

INTERNATIONAL JOURNAL OF DRUG POLICY (2022)

Article Psychology, Clinical

Delta-8 THC use in US adults: Sociodemographic characteristics and correlates

Ofir Livne et al.

Summary: This study examined Delta-8 THC use among adult cannabis users in the US. It found that 16.7% of past 30-day cannabis users reported using Delta-8 THC. The most common method of consumption was vaping concentrated formulations of Delta-8 THC. The primary motivations for use were its legal status and perceived therapeutic benefits. Males were more likely to use Delta-8 THC compared to females, and respondents living in states with restrictions on Delta-8 THC product sales had lower odds of use.

ADDICTIVE BEHAVIORS (2022)

Article Pharmacology & Pharmacy

Application of Oil-in-Water Cannabidiol Emulsion for the Treatment of Rheumatoid Arthritis

Petr Jelinek et al.

Summary: The study demonstrated the significant therapeutic effect of an emulsion formulation containing CBD on rheumatoid arthritis in an animal model, as well as higher oral bioavailability compared to oil solution. Furthermore, CBD absorption via the lymphatic system was confirmed, highlighting the potential of this formulation for improving treatment outcomes in RA.

CANNABIS AND CANNABINOID RESEARCH (2022)

Article Pharmacology & Pharmacy

A Randomized, Triple-Blind, Comparator-Controlled Parallel Study Investigating the Pharmacokinetics of Cannabidiol and Tetrahydrocannabinol in a Novel Delivery System, Solutech, in Association with Cannabis Use History

Volker Berl et al.

Summary: This study compared the pharmacokinetic parameters of Solutech and MCT-oil in a healthy population. The results showed that Solutech had higher C-max, faster elimination and absorption rate constants, shorter time to C-max and lag time, and longer half-life for all analytes compared to MCT-oil. Additionally, cannabis use history significantly influenced the pharmacokinetic parameters of CBD, Delta(9)-THC, 11-OH-THC, and THC-COOH. The evaluation results demonstrated that acute consumption of both products was safe and well tolerated.

CANNABIS AND CANNABINOID RESEARCH (2022)

Article Chemistry, Medicinal

Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

Natasha N. Bondareva Williams et al.

Summary: The study compared the pharmacokinetics of five oral CBD preparations over 4 hours, finding that a preparation with 5% CBD concentration liquid had superior CBD concentration, time, and area under the curve. Fat-free mass was a significant predictor of time to peak concentration for this preparation, and acute CBD ingestion may have a modest influence on autonomic regulation of heart rate.

PHARMACEUTICALS (2021)

Article Pharmacology & Pharmacy

Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characterization

Peter T. Doohan et al.

Summary: The use of medicinal cannabis has increased significantly with global legalization, leading to concerns about drug-drug interactions (DDIs). A study evaluating the inhibitory potential of 12 cannabinoids on drug metabolism showed that most cannabinoids inhibit CYP2C9, with limited effects on other CYP isoforms. In vivo DDI studies may be justified for CYP2C9 substrates with a narrow therapeutic index.

AAPS JOURNAL (2021)

Article Biochemistry & Molecular Biology

The Effects of Food on Cannabidiol Bioaccessibility

Khadijeh Mozaffari et al.

Summary: The study found that the bioaccessibility of CBD is higher when consumed with food, and the presence of bile salts can increase CBD bioaccessibility. Lipase activity and fatty acid absorption also impact the bioaccessibility of CBD.

MOLECULES (2021)

Article Biophysics

Nanoemulsions: An emerging platform for increasing the efficacy of nutraceuticals in foods

Ruojie Zhang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

Article Pharmacology & Pharmacy

Pharmacokinetic investigation of synthetic cannabidiol oral formulations in healthy volunteers

Dvora Izgelov et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

Article Pharmacology & Pharmacy

Cannabis extract nanoemulsions produced by high-intensity ultrasound: Formulation development and scale-up

Shlomo Leibtag et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

Article Pharmacology & Pharmacy

Effect of food on the pharmacokinetics of dronabinol oral solution versus dronabinol capsules in healthy volunteers

D. Alexander Oh et al.

CLINICAL PHARMACOLOGY-ADVANCES AND APPLICATIONS (2017)

Article Energy & Fuels

Continuous-flow production of a pharmaceutical nanoemulsion by high-amplitude ultrasound: Process scale-up

Alexey S. Peshkovsky et al.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2014)

Review Food Science & Technology

Delivery of Lipophilic Bioactives: Assembly, Disassembly, and Reassembly of Lipid Nanoparticles

Mingfei Yao et al.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 5 (2014)

Article Pharmacology & Pharmacy

Bioavailability of bioactive food compounds: a challenging journey to bioefficacy

Maarit J. Rein et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2013)

Article Energy & Fuels

Scalable high-power ultrasonic technology for the production of translucent nanoemulsions

Alexey S. Peshkovsky et al.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2013)

Article Acoustics

Shock-wave model of acoustic cavitation

Sergel L. Peshkovsky et al.

ULTRASONICS SONOCHEMISTRY (2008)

Article Chemistry, Medicinal

Cyclosporin nanoparticulate lipospheres for oral administration

T Bekerman et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2004)