Cytotoxicity studies and antibacterial modification of poly(ethylene 2,5-furandicarboxylate) nonwoven

Novel poly(ethylene 2,5-furandicarboxylate) PEF nonwovens were produced by solution electrospinning and further modification. To improve the wettability of the hydrophobic nonwovens with water, they were treated with sodium hydroxide. Cytotoxicity tests carried out with human keratinocytes confirmed that the nonwovens did not have a toxic effect on healthy cells. The hydrophilicity of the sodium hydroxide treated nonwoven favored the adherence of the cells and their growth. In turn, the two-step modification of the nonwovens by reactions with (3-mercaptopropyl)methyldimethoxysilane and silver nitrate permitted to deposit silver particles on the fiber surfaces. The bacteria growth inhibition zones around the tested specimens were observed evidencing their antibacterial activity against Escherichia coli and Staphylococcus aureus.

Automated summary

Novel PEF nonwovens were successfully produced by solution electrospinning and further modification, showing excellent performance. The hydrophilicity of the nonwovens was improved by sodium hydroxide treatment, and silver particles were deposited on the fiber surfaces through two-step modification with compounds and silver ions, exhibiting good antibacterial activity.