The microRNA-195-5p/hnRNP A1 axis contributes to the progression of hepatocellular carcinoma by regulating the migration of cancer cells

Article Biochemistry & Molecular Biology

miR-195-5p Targets CDK1 To Regulate New DNA Synthesis and Inhibit the Proliferation of Hepatocellular Carcinoma Cells

Chunhui Zhou et al.

Summary: In hepatocellular carcinoma (HCC), miR-195-5p targets CDK1 and inhibits DNA replication and proliferation of HCC cells, thus suppressing cell proliferation.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2023)

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Article Oncology

High Expression of Heterogeneous Nuclear Ribonucleoprotein A1 Facilitates Hepatocellular Carcinoma Growth

Ziyi Cao et al.

Summary: This study aims to explore new markers and therapeutic targets for hepatocellular carcinoma (HCC). It was found that hnRNPA1 expression was upregulated in HCC tissues and correlated with the pathological stage of HCC patients. Knockdown of hnRNPA1 gene inhibited tumor growth in vivo and reversed the effects on proliferation, migration, and invasion, while promoting apoptosis in vitro. Additionally, down-regulation of hnRNPA1 gene expression inhibited the activity of the MEK/ERK pathway.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2023)

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Article Medicine, Research & Experimental

Roles and mechanisms of miR-195-5p in human solid cancers

Qi Xu et al.

Summary: miR-195-5p, as a noncoding RNA, plays an important regulatory role in cancer by affecting various pathways and behaviors of tumor cells. Through studying its expression and mechanisms in different tumors, we believe that miR-195-5p may serve as a novel diagnostic biomarker and therapeutic target for cancer.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Cell Biology

RNA binding protein HuD mediates the crosstalk between β cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression

Myeongwoo Jung et al.

Summary: The RNA binding protein HuD plays a crucial role in gene expression and its dysregulation is associated with various diseases. This study investigated the differential expression of secretory proteins mediated by HuD in mouse insulinoma beta TC6 cells. The results identified endostatin and Serpin E1 as differentially expressed proteins regulated by HuD. HuD knockdown increased the expression of Col18a1, a precursor form of endostatin, and Serpin E1 by interacting with their 3’ untranslated regions. The study also revealed the role of HuD as a translational repressor. HuD downregulation in beta TC6 cells inhibited the growth and migration of islet endothelial cells, and the ectopic expression of HuD in mice affected the expression of Col18a1, Serpin E1, and markers of islet vascular cells.

CELL DEATH & DISEASE (2022)

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Review Cell Biology

Heterogeneous nuclear ribonucleoprotein A/B: an emerging group of cancer biomarkers and therapeutic targets

Ya Lu et al.

Summary: This review focuses on the clinical significance of hnRNPA/B in various cancers and systematically summarizes its biological function and molecular mechanisms.

CELL DEATH DISCOVERY (2022)

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Review Pharmacology & Pharmacy

hnRNP A1 in RNA metabolism regulation and as a potential therapeutic target

Jianguo Feng et al.

Summary: This article highlights the importance of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) in regulating RNA metabolism and its dysregulation in various diseases. The selective binding sites of hnRNP A1 to RNA and DNA are summarized, along with the co-regulatory factors that interact with hnRNP A1. The potential therapeutic implications of targeting hnRNP A1 are discussed, including small-molecule drugs and biomedicines.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Gastroenterology & Hepatology

LncRNA DDX11-AS1 accelerates hepatocellular carcinoma progression via the miR-195-5p/MACC1 pathway

Tao Wan et al.

Summary: In this study, it was found that DDX11-AS1 is upregulated in HCC, and its silencing can inhibit HCC cell proliferation, migration, invasion, and glucose metabolism while promoting apoptosis. Additionally, DDX11-AS1 interacts with miR-195-5p and MACC1, suggesting it may serve as a potential therapeutic target for HCC.

ANNALS OF HEPATOLOGY (2021)

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Review Biochemistry & Molecular Biology

A Comprehensive Analysis of the Role of hnRNP A1 Function and Dysfunction in the Pathogenesis of Neurodegenerative Disease

Joseph P. Clarke et al.

Summary: Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a conserved protein involved in various cellular activities, with potential dysregulation in diseases. Studies have found that dysfunction of hnRNP A1 may contribute to the pathogenesis of neurodegenerative diseases, although the specific mechanisms are still under investigation.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Biochemistry & Molecular Biology

HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation

Hye Guk Ryu et al.

Summary: The study found that HNRNP A1 expression is increased in lung cancer tissues and negatively correlated with overall patient survival. HNRNP A1 plays a role in lung cancer cell proliferation by regulating VRK1 expression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology