Journal
JOURNAL OF FLUORESCENCE
Volume -, Issue -, Pages -Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10895-023-03526-3
Keywords
Fluoride ion; Fluorescent probe; Phenothiazine; Cell imaging
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In this study, a fluorescent probe was developed and synthesized for the detection of fluoride ions. The probe exhibited high selectivity and sensitivity, and was effective in recognizing fluoride ions within cells.
Fluoride is both necessary and potentially harmful in excessive amounts, making its detection crucial. Fluorescent probes provide a sensitive and selective means for this purpose. In this study, we developed and synthesized a fluorescent probe for LDT using phenothiazine derivatives and aryl vinyl nitrile. Initially non-fluorescent, the probe undergoes a Si-O bond breakage in the presence of fluoride ions, resulting in the formation of a larger conjugated system and subsequent fluorescence emission. The probe exhibits superior selectivity and sensitivity towards fluoride ions, with a detection limit of 0.35 mu M. Moreover, cellular imaging experiments demonstrated the probe's effectiveness in recognizing fluoride ions within HepG2 cells.
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