Enhanced Antibacterial and Wound Healing Using a Metal-Organic Cluster Inspired by Artificial Photosynthesis

Bacterial infection poses a constant threat to human health. It is crucial to develop cost-effective and multifunctional solutions to combat bacteria. In this study, inspiration has been taken from artificial photosynthesis and a hydrogel containing a photocatalytic metal-organic cluster (MOC) has been creatively formulated for wound healing and antibacterial purposes. Complete photocatalytic cycles have been achieved by combining the oxidative Ti-center and the reductive Cu-center, in which reactive oxygen species (1O2 and center dot OH) have been generated. The MOC has the capability to eliminate Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) at a concentration of 40 mu g mL-1. In addition, the hydrogel formulation (H-MOC) has been applied to wounds infected with S. aureus, resulting in improved healing efficiency. This work presents an innovative approach to utilizing photocatalytic biomaterials as non-antibiotic medications. Inspired by artificial photosynthesis, a hydrogel formulation of a photocatalytic metal-organic cluster is designed for efficient generation of reactive oxygen species thus for bacteria killing and wound healing. It is approximate to 99% efficient against S. aureus and E. coli at a low dosage (40 mu g mL-1), and its hydrogel formulation shows excellent therapeutic efficiency for healing wounds.image

Automated summary

Inspired by artificial photosynthesis, a hydrogel formulation of a photocatalytic metal-organic cluster is designed for efficient generation of reactive oxygen species thus for bacteria killing and wound healing. It is approximately 99% efficient against S. aureus and E. coli at a low dosage (40 mu g mL-1), and its hydrogel formulation shows excellent therapeutic efficiency for healing wounds.