The diagnostic accuracy of the GeneXpert ESBL-ampC prototype assay for rapid PCR-based detection of extended-spectrum beta-lactamase genes directly from urine

Article Infectious Diseases

Detection of Methicillin-Resistant Staphylococcus aureus Infections Using Molecular Methods

Fred C. Tenover et al.

Summary: The application of molecular detection methods has greatly improved the outcomes of septic patients with MRSA infections. However, the accuracy of molecular tests may be affected by the presence of other staphylococcal species and genetic mutations. Phenotypic methods should be considered when resolving discrepancies between genotypic and phenotypic results.

ANTIBIOTICS-BASEL (2022)

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Review Infectious Diseases

Comparison of the global prevalence and trend of human intestinal carriage of ESBL-producing Escherichia coli between healthcare and community settings: a systematic review and meta-analysis

Yihienew M. Bezabih et al.

Summary: The prevalence of ESBL E. coli in the intestinal tract of both patients and healthy individuals is increasing globally and regionally in both community and healthcare settings. The carriage rates in healthcare settings are generally higher than in community settings.

JAC-ANTIMICROBIAL RESISTANCE (2022)

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Article Infectious Diseases

National point prevalence study on carriage of multidrug-resistant microorganisms in Dutch long-term care facilities in 2018

Esther van Kleef et al.

Summary: The study in Dutch LTCFs showed an estimated prevalence of 8.3% for ESBL-E rectal carriage, mainly observed in E. coli with prevalence of bla(CTX-M-15) and bla(CTX-M-27). No CPE were found in the study. Genetic clusters were identified in more than half of high ESBL-positive LTCFs, indicating potential institutional clonal transmission.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

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Article Immunology

Using Molecular Diagnostics to Develop Therapeutic Strategies for Carbapenem-Resistant Gram-Negative Infections

Fred C. Tenover

Summary: Infections caused by multidrug-resistant Gram-negative organisms, especially those producing carbapenemase, pose a global threat. It is crucial to identify the type of carbapenemase present in the isolate to optimize therapy.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Infectious Diseases