4.7 Article

Buyang Huanwu Decoction suppresses cardiac inflammation and fibrosis in mice after myocardial infarction through inhibition of the TLR4 signalling pathway

Related references

Note: Only part of the references are listed.
Article Plant Sciences

Analysis of the mechanism of Buyang Huanwu Decoction against cerebral ischemia-reperfusion by multi-omics

Huifen Zhou et al.

Summary: This study aims to explore the potential targets of Buyang Huanwu Decoction (BYHW) in the treatment of cerebral ischemia-reperfusion (I/R) using multi-omics analysis methods. Rats with middle cerebral artery occlusion (MCAO) were used to study the effect of BYHW on cerebral I/R injury and analyze potential targets and pathways. The results identified several potential targets and pathways involved in the treatment of cerebral I/R injury.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

Article Chemistry, Multidisciplinary

The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell-cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway

Xue-ling Su et al.

Summary: In this study, the effects of caspase-1 inhibitor VX765 on the expression of Cx43 and cell-to-cell communication after myocardial infarction (MI) were investigated. The results showed that VX765 treatment significantly decreased the infarct area, alleviated cardiac dysfunction and remodeling, and raised Cx43 levels in the heart after MI. In addition, VX765 treatment reversed the downregulation of Cx43 expression and improved intercellular communication in vitro.

ACTA PHARMACOLOGICA SINICA (2022)

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association

Connie W. Tsao et al.

Summary: This article introduces the latest statistics on heart disease, stroke, and cardiovascular risk factors published by the American Heart Association in conjunction with the National Institutes of Health. The Statistical Update includes data on a range of clinical heart and circulatory disease conditions and their associated outcomes. It serves as a critical resource for the general public, policymakers, healthcare professionals, researchers, and others seeking the best available data.

CIRCULATION (2022)

Article Cardiac & Cardiovascular Systems

Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodelling and improves cardiac function

Masum M. Mia et al.

Summary: Yap/Taz play an important regulatory role in MI-induced cardiac fibrosis by controlling fibroblast proliferation, transdifferentiation into myofibroblasts, and fibroinflammatory program.

CARDIOVASCULAR RESEARCH (2022)

Review Cardiac & Cardiovascular Systems

Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

Stefan Frantz et al.

Summary: Most patients survive acute myocardial infarction, but the prevalence of heart failure is increasing, leading to economic strain on healthcare systems. Pathological changes in the heart significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, and female sex can distinctively shape the progression towards heart failure.

EUROPEAN HEART JOURNAL (2022)

Article Pharmacology & Pharmacy

GSK-3β-mediated activation of NLRP3 inflammasome leads to pyroptosis and apoptosis of rat cardiomyocytes and fibroblasts

Shu-Hui Wang et al.

Summary: This study demonstrates that GSK-3 beta mediates the activation of the NLRP3 inflammasome/caspase-1/IL-1 beta pathway, leading to apoptosis and pyroptosis in cardiomyocytes and cardiac fibroblasts.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Article Plant Sciences

Buyang Huanwu Decoction promotes angiogenesis in myocardial infarction through suppression of PTEN and activation of the PI3K/Akt signalling pathway

Xin Han et al.

Summary: This study found that Buyang Huanwu Decoction (BYHWD) can improve myocardial infarction (MI) by promoting angiogenesis. The underlying mechanism involves the suppression of PTEN and activation of the PI3K/Akt/GSK38 signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Review Plant Sciences

Potential activity of Traditional Chinese Medicine against Ulcerative colitis: A review

Yang Liu et al.

Summary: This review provides an overview of the application of traditional Chinese medicine (TCM) in the treatment of ulcerative colitis (UC). Through regulating inflammatory cytokines, intestinal flora, immune system, and protecting the intestinal mucosa, TCM has shown therapeutic effects in treating UC.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Plant Sciences

Huang Bai Jian Pi decoction alleviates diarrhea and represses inflammatory injury via PI3K/Akt/NF-κB pathway: In vivo and in vitro studies

Zunxiang Yan et al.

Summary: This study investigated the therapeutic effect and anti-inflammatory mechanism of Huang Bai Jian Pi (HBJP) decoction on diarrhea in rats. The results showed that HBJP decoction alleviated clinical symptoms and reduced inflammation. It achieved these effects by inhibiting the PI3K/Akt/NF-kappa B signal pathway. These findings suggest that HBJP decoction could be a promising treatment for diarrhea.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Pharmacology & Pharmacy

Elabela ameliorates doxorubicin-induced cardiotoxicity by promoting autophagic flux through TFEB pathway

Deshu Chen et al.

Summary: This study found that elabela (ELA) can improve doxorubicin-induced cardiotoxicity (DIC) by enhancing autophagic flux through activating transcription factor EB (TFEB). ELA may become a potential therapeutic target against DIC.

PHARMACOLOGICAL RESEARCH (2022)

Article Plant Sciences

Ginsenoside Ro, an oleanolic saponin of Panax ginseng, exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway

Hong-Lin Xu et al.

Summary: This study explored the anti-inflammatory effects of Panax ginseng and identified ginsenoside Ro (GRo) as an active component that directly inhibits the TLR4 signaling pathway.

JOURNAL OF GINSENG RESEARCH (2022)

Article Plant Sciences

Glycosides from Buyang Huanwu Decoction inhibit atherosclerotic inflammation via JAK/STAT signaling pathway

Xinying Fu et al.

Summary: This study demonstrated that glycosides, the main active components of BYHWD, can inhibit atherosclerosis progression by alleviating atherosclerotic inflammation, with the inhibitory mechanism targeting the activation of the JAK/STAT signaling pathway.

PHYTOMEDICINE (2022)

Article Cardiac & Cardiovascular Systems

Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart

Prachi Umbarkar et al.

Summary: This study reveals the important role of cardiac fibroblast-GSK-3 alpha in myocardial fibrosis and heart failure, and identifies the molecular mechanism underlying this role through fibroblast kinome mapping. The results suggest that GSK-3 alpha plays a critical role in fibroblast transformation and fibrotic remodeling, independently of the canonical TGF-beta 1-SMAD3 pathway.

CIRCULATION RESEARCH (2022)

Article Plant Sciences

Calycosin reduces myocardial fibrosis and improves cardiac function in post-myocardial infarction mice by suppressing TGFBR1 signaling pathways

Guanghong Chen et al.

Summary: Calycosin attenuates myocardial fibrosis and cardiac dysfunction following myocardial infarction by suppressing the TGFBR1 signaling pathway.

PHYTOMEDICINE (2022)

Article Medicine, Research & Experimental

Traditional Chinese medicine as a therapeutic option for cardiac fibrosis: Pharmacology and mechanisms

Xiao Li et al.

Summary: Cardiovascular diseases are a leading global cause of death, with cardiac fibrosis being a common pathological process in cardiac remodeling. Traditional Chinese medicine shows potential in treating cardiac fibrosis, with the identified mechanisms including inflammation attenuation, fibroblast activation inhibition, and modulation of various systems and pathways.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Cell Biology

Cadherin-11 and cardiac fibrosis: A common target for a common pathology

Lance A. Riley et al.

Summary: Cardiac fibrosis is a major health concern in cardiovascular diseases, characterized by fibroblast activation into myofibroblasts and caused by persistent inflammation and mechanical environment changes. Inhibiting cadherin-11 dimerization shows promise in preventing fibrotic diseases, including cardiac fibrosis, offering potential for improved treatments for heart disease patients.

CELLULAR SIGNALLING (2021)

Article Integrative & Complementary Medicine

Buyang Huanwu Decoction protects against STZ-induced diabetic nephropathy by inhibiting TGF-β/Smad3 signaling-mediated renal fibrosis and inflammation

Weifeng Wu et al.

Summary: The study demonstrated that Buyang Huanwu Decoction (BHD) could effectively improve renal function and alleviate glomerulosclerosis, inflammation, and fibrosis in diabetic nephropathy. The underlying mechanism may involve the inhibition of TGF-beta 1/Smad3 and NF-kappa B signaling pathways.

CHINESE MEDICINE (2021)

Article Pharmacology & Pharmacy

The Anti-Inflammatory and Anti-Pruritus Mechanisms of Huanglian Jiedu Decoction in the Treatment of Atopic Dermatitis

Yubin Xu et al.

Summary: The study indicates that Huanglian Jiedu decoction can treat atopic dermatitis by regulating the antigen presentation function of dendritic cells, weakening T-lymphocyte activation, and subsequently exerting anti-inflammatory and anti-pruritus effects.

FRONTIERS IN PHARMACOLOGY (2021)

Article Plant Sciences

Buyang Huanwu Decoction ameliorates atherosclerosis by regulating TGF-β/Smad2 pathway to promote the differentiation of regulatory T cells

Shujing Chen et al.

Summary: This study demonstrated that BYHWD regulates the TGF-beta/Smad2 signaling pathway to promote the peripheral differentiation of Tregs, increase the number of Tregs, restore the immune balance between CD4(+) T cells, regulate lipid metabolism, inhibit inflammatory reaction, and potentially enhance plaque stability.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Plant Sciences

Pharmacokinetics-based comprehensive strategy to identify multiple effective components in Huangqi decoction against liver fibrosis

Yahang Wang et al.

Summary: Using a pharmacokinetics-based comprehensive strategy, multiple effective components in HQD were identified to act together against liver fibrosis, including astragaloside IV, cycloastragenol, glycyrrhizic acid, and glycyrrhetinic acid.

PHYTOMEDICINE (2021)

Article Pharmacology & Pharmacy

BYHWD Alleviates Inflammatory Response by NIK-Mediated Repression of the Noncanonical NF-κB Pathway During ICH Recovery

Wei Xiao et al.

Summary: Intracerebral hemorrhage (ICH) induces inflammatory response that affects brain repair and organism recovery. Research suggests that Buyang Huanwu Decoction (BYHWD) can attenuate the inflammatory response during ICH recovery in rats by inhibiting the NIK-mediated noncanonical NF-kappa B signaling pathway, improving neurological function in rats.

FRONTIERS IN PHARMACOLOGY (2021)

Review Immunology

NLRP3 inflammasome activation and cell death

Yi Huang et al.

Summary: The NLRP3 inflammasome is a cytosolic multiprotein complex that responds to microbial infection, endogenous danger signals, and environmental stimuli. Its activation can induce pyroptosis and release of inflammatory cytokines, contributing to innate immune defense. However, aberrant activation of the NLRP3 inflammasome is associated with inflammatory diseases, and there is a close relationship between cell death pathways and NLRP3 inflammasome activation.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Review Cell Biology

Cardiac Fibrosis and Fibroblasts

Hitoshi Kurose

Summary: Cardiac fibrosis is caused by excess deposition of extracellular matrix, particularly collagen. While appropriate collagen production is beneficial for heart integrity, excessive deposition can lead to cardiac dysfunction. Recent research has shown that myofibroblasts not only produce ECM, but also have functions similar to macrophages.

CELLS (2021)

Review Cardiac & Cardiovascular Systems

Cardiac fibrosis

Nikolaos G. Frangogiannis

Summary: Myocardial fibrosis, characterized by the expansion of cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic feature in various myocardial conditions. Activated fibroblasts and myofibroblasts play a central role in cardiac fibrosis, producing matrix proteins and triggering fibrogenic signalling cascades in response to stress. Immune cells, vascular cells, and cardiomyocytes can also contribute to fibrosis, while fibrotic changes may disrupt cardiac function and play a role in arrhythmogenesis.

CARDIOVASCULAR RESEARCH (2021)

Review Pharmacology & Pharmacy

Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis

Anita A. Pinar et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Review Biochemistry & Molecular Biology

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

Nikolaos G. Frangogiannis

MOLECULAR ASPECTS OF MEDICINE (2019)

Review Cardiac & Cardiovascular Systems

Inflammation and fibrosis in murine models of heart failure

Lucas Bacmeister et al.

BASIC RESEARCH IN CARDIOLOGY (2019)

Review Biochemistry & Molecular Biology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Immunology

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

Morena Zusso et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Article Biochemistry & Molecular Biology

Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis

Xi-Chun Pan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Cardiac fibrosis: new insights into the pathogenesis

Zhen-Guo Ma et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Review Immunology

Cardioimmunology: the immune system in cardiac homeostasis and disease

Filip K. Swirski et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases

Dongling Liu et al.

BASIC RESEARCH IN CARDIOLOGY (2018)

Article Plant Sciences

Traditional Chinese medicine for pulmonary fibrosis therapy: Progress and future prospects

Liu-Cheng Li et al.

JOURNAL OF ETHNOPHARMACOLOGY (2017)

Review Medicine, General & Internal

Acute Myocardial Infarction

Jeffrey L. Anderson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Cardiac & Cardiovascular Systems

Fibroblasts in myocardial infarction: A role in inflammation and repair

Arti V. Shinde et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)

Article Cardiac & Cardiovascular Systems

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemiareperfusion injury

Oystein Sandanger et al.

CARDIOVASCULAR RESEARCH (2013)

Article Chemistry, Analytical

Effect of Buyang Huanwu decoction on amino acid content in cerebrospinal fluid of rats during ischemic/reperfusion injury

Lisheng Wang et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2013)

Article Cardiac & Cardiovascular Systems

Inflammatory Cytokines in Heart Failure: Mediators and Markers

Lars Gullestad et al.

CARDIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

Masanori Kawaguchi et al.

CIRCULATION (2011)

Article Multidisciplinary Sciences

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou et al.

NATURE (2011)

Review Microbiology

The molecular basis of the host response to lipopolysaccharide

Clare E. Bryant et al.

NATURE REVIEWS MICROBIOLOGY (2010)

Review Biochemistry & Molecular Biology

Introduction to NF-κB:: players, pathways, perspectives

T. D. Gilmore

ONCOGENE (2006)