Nickel-Catalyzed Hydroalkynylation of 1,3-Dienes with Simple Alkynes

A hydroalkynylation reaction of 1,3-dienes with simplealkynes, facilitated by an efficient nickel catalyst system with the 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (Xantphos) ligand, ispresented. This reaction displays a broad substrate range for alkynes,encompassing both aryl alkynes and alkyl alkynes, thereby overcomingprevious constraints in 1,3-diene hydroalkynylation. The method offersa convenient and direct means for obtaining allylic alkynes with highatom and step economy.

Automated summary

A method for hydroalkynylation reaction of 1,3-dienes with simple alkynes using an efficient nickel catalyst system and Xantphos ligand is presented. This method overcomes previous constraints in 1,3-diene hydroalkynylation and offers a convenient and direct means for obtaining a wide range of allylic alkynes.