4.7 Article

Microcystin-LR-induced autophagy via miR-282-5p/PIK3R1 pathway in Eriocheir sinensis hepatopancreas

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

Risk assessment and identification of factors influencing the historical concentrations of microcystin in Lake Taihu, China

Chen Cheng et al.

Summary: Understanding the historical pollution of microcystins in large lakes is important for informing lake management. The study found that the content of microcystins increased over time in sediment cores collected from Lake Taihu. Different environmental factors were identified as drivers of microcystins in different lake zones, with phosphorus and nitrogen being the most important drivers at the whole lake scale. The study also revealed an increase in both ecological and public health risks associated with microcystins in recent years.

JOURNAL OF ENVIRONMENTAL SCIENCES (2023)

Article Toxicology

Microcystin-LR-induced nuclear translocation of cGAS promotes mutagenesis in human hepatocytes by impeding homologous recombination repair

Xiaofei Wang et al.

Summary: This study focused on the mutagenic effect of MC-LR on human normal hepatic cells and revealed that MC-LR can activate the cGAS-STING signaling pathway, trigger immune response, and inhibit homologous recombination repair, leading to increased mutation frequency.

TOXICOLOGY LETTERS (2023)

Article Toxicology

Microcystin-LR-induced autophagy regulates oxidative stress, inflammation, and apoptosis in grass carp ovary cells in vitro

Lili Wei et al.

Summary: This study found that MC-LR can induce autophagy and apoptosis in GCO cells in vitro, and inhibition of autophagy can decrease the extent of apoptosis, induce more serious oxidative stress and inflammation, and eventually result in cell death. These findings provide some information for exploring the toxicity of MC-LR, but the role of autophagy in vivo requires further study.

TOXICOLOGY IN VITRO (2023)

Article Biochemistry & Molecular Biology

GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux

Xiaoxiao Ji et al.

Summary: Based on genetic associations, GSTP1 may be associated with bone mineral density. This study investigated how GSTP1 affects bone homeostasis through in vitro and in vivo experiments. It was discovered that GSTP1 regulates osteoclast formation by altering autophagic flux via the Pik3r1-AKT-mTOR axis. This study provides a new mechanism for understanding the role of GSTP1 in osteoclastogenesis.

REDOX BIOLOGY (2023)

Article Toxicology

Functional variants of RPS6KB1 and PIK3R1 in the autophagy pathway genes and risk of bladder cancer

Lan Ma et al.

Summary: Genetic variants in autophagy pathway genes RPS6KB1 and PIK3R1 are associated with susceptibility to bladder cancer. Additionally, several functional SNPs are significantly correlated with bladder cancer risk.

ARCHIVES OF TOXICOLOGY (2022)

Article Biochemistry & Molecular Biology

The miR-282-5p regulates larval moulting process by targeting chitinase 5 in Bombyx mori

Yun Wang et al.

Summary: The study revealed that miR-282-5p coordinates the regulation of chitinase 5 in the moulting process of silkworms, and the 20E signaling pathway plays a crucial role in normal moulting.

INSECT MOLECULAR BIOLOGY (2022)

Article Environmental Sciences

Lipid metabolism, immune and apoptosis transcriptomic responses of the hepatopancreas of Chinese mitten crab to the exposure to microcystin-LR

Cheng Chi et al.

Summary: Global warming increases harmful cyanobacterial blooms, and microcystin-LR (MC-LR) is a hepatotoxic agent produced during these blooms. This study injected different doses of MC-LR into the hepatopancreas of Chinese mitten crab and found that it affected gene expression, leading to triglyceride accumulation and changes in sterol metabolism, apoptosis, and actin cytoskeleton regulation.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Environmental Sciences

Microcystin-LR induces apoptosis in Juvenile Eriocheir sinensis via the mitochondrial pathway

Yuning Zhang et al.

Summary: This study assessed the toxicity of MC-LR to a freshwater crab and found that it caused oxidative stress and apoptosis, mediated through the mitochondrial pathway. The regulation of oxidative stress and apoptosis may play a crucial role in the hepatotoxicity of MC-LR.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Environmental Sciences

Autophagic event and metabolomic disorders unveil cellular toxicity of environmental microplastics on marine polychaete Hediste diversicolor*

Omayma Missawi et al.

Summary: This study evaluates the impact of different environmental microplastics (MPs) collected from the south coast of the Mediterranean Sea on the metabolome and proteome of the marine polychaete Hediste diversicolor. The results show that MPs cause cytoskeleton damage and induce abnormal autophagy pathway in polychaetes. Metabolomics analysis reveals altered metabolic profiles in polychaetes treated with MPs, with elevated levels of amino acids, glucose, and other substances, and reduced concentration of aspartate.

ENVIRONMENTAL POLLUTION (2022)

Article Environmental Sciences

Responses of lipid metabolism and lipidomics in the hepatopancreas of Pacific white shrimp Litopenaeus vannamei to microcystin-LR exposure

Yafei Duan et al.

Summary: In this study, the effects of Microcystin-LR (MC-LR) on lipid metabolism and lipidomic responses in Litopenaeus vannamei hepatopancreas were investigated. The results showed that MC-LR exposure caused tissue damage and decreased the activities of several lipase isoenzymes in the hepatopancreas. Additionally, the relative gene expression levels of key genes involved in lipolysis, lipogenesis, and fatty acid beta-oxidation were increased. Lipidomic analysis revealed that MC-LR exposure resulted in increased levels of glycerophospholipids, sphingolipids, and cholesteryl ester, while the levels of phosphatidylinositol and triglyceride were decreased. These findings provide important insights into the effects of MC-LR on lipid metabolism and lipidomic homeostasis in shrimp hepatopancreas.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Environmental Sciences

Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder

Can Du et al.

Summary: This study found that chronic exposure to low concentrations of MC-LR caused a disorder in hepatic lipid metabolism and liver inflammation, indicating potential harm to liver health from MC-LR.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Environmental Sciences

Polystyrene microplastics increase Pb bioaccumulation and health damage in the Chinese mitten crab Eriocheir sinensis

Zhigang Yang et al.

Summary: The combination of microplastics and lead exposure had a more severe impact on the bioaccumulation of lead, oxidative stress, lipid metabolism, and liver injury in Chinese mitten crabs. This study provides insights into the response of economic crustaceans to the combined stress of lead and microplastics.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Environmental Sciences

Effect of polystyrene nanoplastics on cell apoptosis, glucose metabolism, and antibacterial immunity of Eriocheir sinensis

Xingyu Nan et al.

Summary: Using Chinese mitten crabs as a model, this study investigated the effects of polystyrene nanoplastics (PS NPs) on cell apoptosis, glucose metabolism, and antibacterial immunity. The results showed that PS NPs were endocytosed by crab hemocytes, leading to abnormal cell apoptosis, glucose metabolism disorder, and changes in antimicrobial immunity.

ENVIRONMENTAL POLLUTION (2022)

Article Environmental Sciences

Quantitative benefit and risk assessment of cadmium and nutrient levels in Chinese mitten crab (Eriocheir sinensis)

Zihao Fan et al.

Summary: The study found that the issue of Chinese mitten crabs ingesting the heavy metal cadmium is still unresolved, while feeding crabs with iced trash fish and formulated feed results in different nutritional levels. However, there is no significant difference in the hazard quotient of benefit and risk balance between the two. Moderately consuming crabs can help promote the healthy development of the Chinese mitten crab industry.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

Review Marine & Freshwater Biology

Toxic effects of cyanotoxins in teleost fish: A comprehensive review

Sambuddha Banerjee et al.

Summary: Eutrophication leads to algal blooms, which can produce cyanotoxins with detrimental effects on the ecosystem and food web. Despite fishes being vital in aquatic ecosystems, there is limited research on the toxic potentials of cyanotoxins in fish. The review highlights the major toxicological impacts of cyanotoxins in teleost fishes and suggests future research areas focusing on molecular mechanisms and reproductive toxicity.

AQUATIC TOXICOLOGY (2021)

Review Oncology

An overview of autophagy: Mechanism, regulation and research progress

Weiya Cao et al.

Summary: Autophagy is a process in cells where autophagosomes are formed to degrade cellular contents for cell homeostasis. It involves complex regulatory mechanisms and multiple signaling pathways. Autophagy and apoptosis share common stimulating factors and regulatory proteins, but differ in their induction thresholds.

BULLETIN DU CANCER (2021)

Article Food Science & Technology

IRE1 and CaMKKβ pathways to reveal the mechanism involved in microcystin-LR-induced autophagy in mouse ovarian cells

Ya Ma et al.

Summary: MC-LR induces autophagy in ovarian cells and ovarian injury via the IRE1 and CaMKK beta pathways. Inhibition of these pathways can significantly alleviate autophagy and damage induced by MC-LR.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Chemistry, Applied

Occurrence and health risk assessment of residual heavy metals in the Chinese mitten crab (Eriocheir sinensis)

Wang Qian et al.

Summary: The study found that the main sources of heavy metals in Chinese mitten crabs are agricultural activities, industrial discharges, and urban sewage. Although harmful heavy metals such as arsenic, mercury, and lead are present in the crabs, their intake levels are below national standards, leading to a low dietary risk for consumers.

JOURNAL OF FOOD COMPOSITION AND ANALYSIS (2021)

Article Environmental Sciences

The activated ATM/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells

Zhihui Tian et al.

Summary: The study revealed that oxidative stress induced by MC-LR can activate the DNA damage-mediated ATM/p53 signaling pathway to induce autophagy in male germ cells.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Pva-miR-252 participates in ammonia nitrogen-induced oxidative stress by modulating autophagy in Penaeus vannamei

Feifei Wang et al.

Summary: The study revealed that under ammonia nitrogen stress, the miRNA pva-miR-252 in shrimp positively regulates autophagy through PvPI3K and enhances antioxidant enzyme activity, providing protection for shrimp.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Fisheries

Ophiopogon japonicus inhibits white spot syndrome virus proliferation in vivo and enhances immune response in Chinese mitten crab Eriocheir sinensis

Cheng Chen et al.

Summary: The study showed that Ophiopogon japonicus extract has strong anti-WSSV activity, reducing viral loads and improving survival of crabs challenged with WSSV. It may inhibit WSSV proliferation by repressing the JAK-STAT pathway and modulating immune gene expression. O. japonicus could potentially be developed into a preventive or therapeutic agent against WSSV, with further research needed on its effective compounds.

FISH & SHELLFISH IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling

Shahrokh Lorzadeh et al.

Summary: The interplay between autophagy and Wnt signaling pathways is crucial for regulating cellular homeostasis and adaptation to environmental conditions. Autophagy degrades and recycles cellular materials, while Wnt signaling is involved in embryogenesis and differentiation.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Cell Biology

Downregulation of miR-128 Ameliorates Ang II-Induced Cardiac Remodeling via SIRT1/PIK3R1 Multiple Targets

Heqin Zhan et al.

Summary: Research showed that miR-128 plays a crucial role in chronic cardiac remodeling induced by Ang II, and downregulation of miR-128 can alleviate cardiac dysfunction, hypertrophy, fibrosis, apoptosis, and oxidative stress, likely through targeting PIK3R1/Akt/mTORC1 and/or SIRT1/p53 pathways.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Review Biochemistry & Molecular Biology

Beyond Autophagy: The Expanding Roles of ATG8 Proteins

Jose L. Nieto-Torres et al.

Summary: The ATG8 family proteins are key players in autophagy, participating in cargo recruitment, biogenesis, transport, and fusion with lysosomes. Recent studies have shown their involvement in diverse processes such as vesicle maturation and cargo specification, with complex regulatory mechanisms that are still not fully understood. Individual roles of different ATG8 family members in canonical or non-canonical pathways remain unclear. This review highlights the molecular questions surrounding ATG8s that are only beginning to be explored.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Article Biotechnology & Applied Microbiology

Transcriptome analysis of five ovarian stages reveals gonad maturation in female updates Macrobrachium nipponense

Yuning Zhang et al.

Summary: The study provides detailed transcriptome data on the ovarian maturation cycle in M. nipponense, identifying key genes related to vitellogenin hydrolysis and oocyte excretion. This information can serve as an important reference for genomics, molecular biology, physiology, and population genetics of M. nipponense and other crustaceans, aiding in addressing the issue of rapid ovarian maturation in M. nipponense.

BMC GENOMICS (2021)

Article Environmental Sciences

Inhibition of endoplasmic reticulum stress-related autophagy attenuates MCLR-induced apoptosis in zebrafish testis and mouse TM4 cells

Zaiwei Wu et al.

Summary: This study demonstrates that MCLR causes damage to the male reproductive system and enhances autophagy, indicating the essential role of autophagy in MCLR-induced cell death. Furthermore, the study reveals the involvement of ER stress-related autophagy pathway in MCLR-induced apoptosis and injury in the male reproductive system.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Biochemistry & Molecular Biology

Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages

Robin C. Su et al.

Summary: In patients with colitis, microcystin-LR can exacerbate inflammation by affecting macrophage activation, and doramapimod has been found to effectively prevent MC-LR-induced inflammatory responses.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, General & Internal

Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans

Jack J. Collier et al.

Summary: This study identified several patients with neurodevelopmental disorders who survived with severe loss or complete absence of ATG7, an essential effector enzyme for autophagy without a known functional paralogue.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Environmental Sciences

MicroRNA-16 participates in the cell cycle alteration of HepG2 cells induced by MC-LR

Yiyi Feng et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

Article Biochemistry & Molecular Biology

20-Hydroxyecdysone-responsive microRNAs of insects

Xiaoli Jin et al.

RNA BIOLOGY (2020)

Review Food Science & Technology

Occurrence and toxicity of microcystin congeners other than MC-LR and MC-RR: A review

Leticia Diez-Quijada et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Environmental Sciences

Influence of microcystins-LR (MC-LR) on autophagy in human neuroblastoma SK-N-SH cells

Yue Yang et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2019)

Article Environmental Sciences

MicroRNA expression profiling involved in MC-LR-induced hepatotoxicity using high-throughput sequencing analysis

Shu Yang et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2018)

Article Allergy

MicroRNA

Thomas X. Lu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

A molecular perspective of mammalian autophagosome biogenesis

Thomas J. Mercer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Environmental Sciences

An overview of the accumulation of microcystins in aquatic ecosystems

Thanh-Luu Pham et al.

JOURNAL OF ENVIRONMENTAL MANAGEMENT (2018)

Article Multidisciplinary Sciences

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

Karen Frudd et al.

NATURE COMMUNICATIONS (2018)

Article Medical Laboratory Technology

Elevated levels of serum MiR-152 and miR-24 in uterine sarcoma: potential for inducing autophagy via SIRT1 and deacetylated LC3

X. Tong et al.

BRITISH JOURNAL OF BIOMEDICAL SCIENCE (2018)

Article Biochemistry & Molecular Biology

Identification of Differentially Expressed miRNAs in Colorado Potato Beetles (Leptinotarsa decemlineata (Say)) Exposed to Imidacloprid

Mathieu D. Morin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Medicine, Research & Experimental

Autophagy: The spotlight for cellular stress responses

Palaniyandi Ravanan et al.

LIFE SCIENCES (2017)

Review Pharmacology & Pharmacy

The mechanistic role of chemically diverse metal ions in the induction of autophagy

Sumit Sahni et al.

PHARMACOLOGICAL RESEARCH (2017)

Review Toxicology

MicroRNAs and toxicology: A love marriage

Elisabeth Schraml et al.

TOXICOLOGY REPORTS (2017)

Article Biochemistry & Molecular Biology

LC3/GABARAP family proteins: autophagy-(un) related functions

Marco B. E. Schaaf et al.

FASEB JOURNAL (2016)

Article Fisheries

The role of shrimp miR-965 in virus infection

Le Shu et al.

FISH & SHELLFISH IMMUNOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Regulation of autophagy by Beclin 1 in the heart

Yasuhiro Maejima et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

Review Cell Biology

Autophagy and epithelial-mesenchymal transition: an intricate interplay in cancer

Mila Gugnoni et al.

CELL DEATH & DISEASE (2016)

Article Multidisciplinary Sciences

Autophagy mediates degradation of nuclear lamina

Zhixun Dou et al.

NATURE (2015)

Review Endocrinology & Metabolism

Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy

Shinji Kume et al.

DIABETES & METABOLISM JOURNAL (2015)

Article Biotechnology & Applied Microbiology

MicroRNAs as potential biomarkers in diseases and toxicology

Benazir Siddeek et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2014)

Review Biochemistry & Molecular Biology

Lipids in autophagy: Constituents, signaling molecules and cargo with relevance to disease

Helene Knaevelsrud et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)

Article Multidisciplinary Sciences

NGS QC Toolkit: A Toolkit for Quality Control of Next Generation Sequencing Data

Ravi K. Patel et al.

PLOS ONE (2012)

Article Cell Biology

Role of autophagy in suppression of inflammation and cancer

Eileen White et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

Article Cell Biology

The Beclin 1 interactome

Congcong He et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Regulation of autophagy by phosphatidylinositol 3-phosphate

Chloe Burman et al.

FEBS LETTERS (2010)

Article Gastroenterology & Hepatology

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

Wen-Xing Ding et al.

GASTROENTEROLOGY (2010)

Article Biochemistry & Molecular Biology

The complexities of microRNA regulation: mirandering around the rules

Kimberly Breving et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Autophagy and the Integrated Stress Response

Guido Kroemer et al.

MOLECULAR CELL (2010)

Review Immunology

Physiological and pathological roles for microRNAs in the immune system

Ryan M. O'Connell et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Editorial Material Cell Biology

Cardiomyocyte autophagy is regulated by angiotensin II type 1 and type 2 receptors

Enzo R. Porrello et al.

AUTOPHAGY (2009)

Review Biochemistry & Molecular Biology

A microRNA component of the hypoxic response

R. Kulshreshtha et al.

CELL DEATH AND DIFFERENTIATION (2008)

Article Urology & Nephrology

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

Sudharsan Periyasamy-Thandavan et al.

KIDNEY INTERNATIONAL (2008)

Review Biochemistry & Molecular Biology

PI3K pathway alterations in cancer: variations on a theme

T. L. Yuan et al.

ONCOGENE (2008)

Editorial Material Multidisciplinary Sciences

Gene regulation by transcription factors and microRNAs

Oliver Hobert

SCIENCE (2008)

Review Toxicology

The dynamic epigenome and its implications in toxicology

Moshe Szyf

TOXICOLOGICAL SCIENCES (2007)

Review Food Science & Technology

Toxins of cyanobacteria

Marian E. van Apeldoorn et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2007)

Article Oncology

Carcinogenicity of nitrate, nitrite, and cyanobacterial peptide toxins

Yann Grosse et al.

LANCET ONCOLOGY (2006)

Article Biochemistry & Molecular Biology

RNAhybrid:: microRNA target prediction easy, fast and flexible

Jan Krueger et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Cell Biology

Repbase update, a database of eukaryotic repetitive elements

J Jurka et al.

CYTOGENETIC AND GENOME RESEARCH (2005)

Article Biochemistry & Molecular Biology

Rfam: an RNA family database

S Griffiths-Jones et al.

NUCLEIC ACIDS RESEARCH (2003)