4.7 Article

Endogenous Extracellular Vesicles Participate in Brain Remodeling after Ischemic Stroke

Journal

Publisher

MDPI
DOI: 10.3390/ijms242316857

Keywords

cerebral ischemia; exosomes; neuroprotection; glial activation; neurogenesis; angiogenesis

Ask authors/readers for more resources

This study investigates the role of extracellular vesicles in endogenous repair within the neurovascular unit after ischemic stroke. The findings suggest that CD63 exosomes are spatially and temporally associated with glial activation, neurogenesis, and angiogenesis, indicating their potential contribution to the repair of the neurovascular unit.
Brain remodeling after an ischemic stroke represents a promising avenue for exploring the cellular mechanisms of endogenous brain repair. A deeper understanding of these mechanisms is crucial for optimizing the safety and efficacy of neuroprotective treatments for stroke patients. Here, we interrogated the role of extracellular vesicles, particularly exosomes, as potential mediators of endogenous repair within the neurovascular unit (NVU). We hypothesized that these extracellular vesicles may play a role in achieving transient stroke neuroprotection. Using the established ischemic stroke model of middle cerebral artery occlusion in adult rats, we detected a surged in the extracellular vesicle marker CD63 in the peri-infarct area that either juxtaposed or co-localized with GFAP-positive glial cells, MAP2-labeled young neurons, and VEGF-marked angiogenic cells. This novel observation that CD63 exosomes spatially and temporally approximated glial activation, neurogenesis, and angiogenesis suggests that extracellular vesicles, especially exosomes, contribute to the endogenous repair of the NVU, warranting exploration of extracellular vesicle-based stroke therapeutics.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available