☆ 4.7 Article

Peptide absent sequences emerging in human cancers

EUROPEAN JOURNAL OF CANCER (2024)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

GENCODE: reference annotation for the human and mouse genomes in 2023

Adam Frankish et al.

Summary: GENCODE provides high quality gene and transcript annotation for the human and mouse genomes, supported by experimental data, serving as a reference for genome biology and clinical genomics. The consortium generates data, develops tools and carries out analyses to support the identification and annotation of transcript structures and their function.

NUCLEIC ACIDS RESEARCH (2023)

Add to Collection

Review Oncology

Cell-free DNA analysis in current cancer clinical trials: a review

M. Cisneros-Villanueva et al.

Summary: Cell-free DNA analysis is a promising method for the diagnosis and treatment selection of cancer patients. Despite the need for standardization and technical validation, numerous clinical trials have shown its potential in early cancer detection and treatment improvement.

BRITISH JOURNAL OF CANCER (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Proteomics technologies for cancer liquid biopsies

Zhiyong Ding et al.

Summary: The complexity of proteomes in liquid biopsy samples and the limitations of proteomic technologies compared to high-plex sequencing technologies have hindered the development of proteomics. However, novel protein technologies are urgently needed for biomarker discovery in cancer liquid biopsies. Traditional and innovative proteomic technologies are being rapidly developed and have greatly facilitated early detection, diagnosis, prognosis, and monitoring of cancer evolution.

MOLECULAR CANCER (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Identification of neoantigens for individualized therapeutic cancer vaccines

Franziska Lang et al.

Summary: This Review discusses the use of tumor-specific neoantigens in anticancer vaccines and introduces the mechanisms of neoantigen T cell recognition, as well as computational approaches to predict which neoantigens might confer proficient antitumor immunity in patients. Individualized treatment approaches are required to harness the full potential of the unique cancer mutations in each patient. Computational algorithms and machine-learning tools can be used to identify mutations, prioritize T cell-recognized antigens, and design personalized vaccines for each patient.

NATURE REVIEWS DRUG DISCOVERY (2022)

Add to Collection

Review Engineering, Biomedical

Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics

Ping Song et al.

Summary: This Review discusses the challenges and opportunities of technologies for the analysis of cell-free DNA for cancer diagnosis. It highlights the potential of cfDNA as biomarkers for guiding therapy, monitoring drug resistance, and early detection of cancers. However, the low concentrations and fragmented nature of cfDNA present challenges for clinical diagnostic applications. The Review describes state-of-the-art technologies and highlights the need to address biological and technical challenges to improve cancer diagnostics and patient care.

NATURE BIOMEDICAL ENGINEERING (2022)

Add to Collection

Review Oncology

Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations

Ulf Landegren et al.

Summary: Current protein biomarkers and detection methods fall short of meeting the needs for accurate cancer diagnosis, highlighting the importance of exploring biomarkers deep within the proteome. The molecular detection sensitivity of protein assays lags behind nucleic acid detection reactions, necessitating improvements to ensure early detection of malignant growth through liquid biopsy.

MOLECULAR ONCOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Significant non-existence of sequences in genomes and proteomes

Grigorios Koulouras et al.

Summary: The study reveals significant absent oligomers using Markov models and suggests their absence is due to negative selection. Common significant MAWs are often mono- or dinucleotide tracts. MAWs in mammal genomes are often present but rare in other mammals, while human MAWs are frequently present in prokaryotes but rarely in human viruses.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Review Oncology

A Review of Circulating Tumour Cell Enrichment Technologies

Amelia J. Rushton et al.

Summary: Circulating tumor cells (CTCs) are shed from tumors into the bloodstream and have the potential to provide important insights into cancer detection and monitoring. CellSearch is the only FDA-approved technology for determining the prognosis of patients with advanced breast, prostate, and colorectal cancers, but new label-free enrichment technologies are emerging.

CANCERS (2021)

Add to Collection

Review Oncology

Identification and Targeting of Mutant Peptide Neoantigens in Cancer Immunotherapy

Daniel J. Verdon et al.

Summary: This review discusses the identification of neoantigens as a key immune target in cancer therapy, and the development of technologies for detecting patient-specific mutations giving rise to these neoantigens. It also examines the therapeutic modalities targeting neoantigens, such as adoptive cell transfer and checkpoint blockade therapies, that have shown promise in preclinical and clinical settings.

CANCERS (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Absent from DNA and protein: genomic characterization of nullomers and nullpeptides across functional categories and evolution

Ilias Georgakopoulos-Soares et al.

Summary: This study identifies nullomers and nullpeptides in different organisms, showing that specific functional categories may be more likely to be selected against, and that nullpeptides can be used as markers to distinguish different human populations and for phylogenetic classification.

GENOME BIOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

The repertoire of mutational signatures in human cancer

Ludmil B. Alexandrov et al.

NATURE (2020)

Add to Collection

Article Oncology

Clinical utility of tumour marker velocity of cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) in breast cancer surveillance

J. X. Hing et al.

BREAST (2020)

Add to Collection

Article Biochemical Research Methods

Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection

Georgina D. Barnabas et al.

MOLECULAR & CELLULAR PROTEOMICS (2019)

Add to Collection

News Item Medicine, General & Internal

Cancer survival data emphasise importance of early diagnosis

Nigel Hawkes

BMJ-BRITISH MEDICAL JOURNAL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade

Lee P. Richman et al.

CELL SYSTEMS (2019)

Add to Collection

Review Genetics & Heredity

DNA Methylation Cancer Biomarkers: Translation to the Clinic

Warwick J. Locke et al.

FRONTIERS IN GENETICS (2019)

Add to Collection

Review Gastroenterology & Hepatology

A Review of the Role of Carcinoembryonic Antigen in Clinical Practice

Claire Hall et al.

ANNALS OF COLOPROCTOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Comprehensive Characterization of Cancer Driver Genes and Mutations

Matthew H. Bailey et al.

CELL (2018)

Add to Collection

Review Pathology

The potential of circulating cell-free RNA as a cancer biomarker: challenges and opportunities

Ivan A. Zaporozhchenko et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

Kyle Ellrott et al.

CELL SYSTEMS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Maftools: efficient and comprehensive analysis of somatic variants in cancer

Anand Mayakonda et al.

GENOME RESEARCH (2018)

Add to Collection

Article Oncology

The effect of Nullomer-derived peptides 9R, 9S1R and 124R on the NCI-60 panel and normal cell lines

Abdelkrim Alileche et al.

BMC CANCER (2017)

Add to Collection

Review Cell Biology

Systems Biology of Metabolism: A Driver for Developing Personalized and Precision Medicine

Jens Nielsen

CELL METABOLISM (2017)

Add to Collection

Article Multidisciplinary Sciences

Nullomers and High Order Nullomers in Genomic Sequences

Davide Vergni et al.

PLOS ONE (2016)

Add to Collection

Article Multidisciplinary Sciences

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

Mahesh Yadav et al.

NATURE (2014)

Add to Collection

Article Multidisciplinary Sciences

Pentamers Not Found in the Universal Proteome Can Enhance Antigen Specific Immune Responses and Adjuvant Vaccines

Ami Patel et al.

PLOS ONE (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Nullomer derived anticancer peptides (NulloPs): Differential lethal effects on normal and cancer cells in vitro

Abdelkrim Alileche et al.

PEPTIDES (2012)

Add to Collection

Article Health Care Sciences & Services

Protein Analytical Assays for Diagnosing, Monitoring, and Choosing Treatment for Cancer Patients

Alicia D. Powers et al.

JOURNAL OF HEALTHCARE ENGINEERING (2012)

Add to Collection

Review Oncology

SGO White Paper on Ovarian Cancer: Etiology, Screening and Surveillance

John O. Schorge et al.

GYNECOLOGIC ONCOLOGY (2010)

Add to Collection

Article Multidisciplinary Sciences

Nullomers: Really a Matter of Natural Selection?

Claudia Acquisti et al.

PLOS ONE (2007)

Add to Collection

Article Genetics & Heredity

Discriminating self from nonself with short peptides from large proteomes

NJ Burroughs et al.

IMMUNOGENETICS (2004)

Add to Collection

Review Biochemical Research Methods

The human plasma proteome - History, character, and diagnostic prospects

NL Anderson et al.

MOLECULAR & CELLULAR PROTEOMICS (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.