Complement-pentraxins synergy: Navigating the immune battlefield and beyond

The complement is a crucial immune defense system that triggers rapid immune responses and offers efficient protection against foreign invaders and unwanted host elements, acting as a sentinel. Activation of the complement system occurs upon the recognition of pathogenic microorganisms or altered self-cells by pattern recognition molecules (PRMs) such as C1q, collectins, ficolins, and pentraxins. Recent accumulating evidence shows that pentraxins establish a cooperative network with different classes of effector PRMs, resulting in synergistic effects in complement activation. This review describes the complex interaction of pentraxins with the complement system and the implications of this cooperative network for effective host defense during pathogen invasion.

Automated summary

The complement system is an important immune defense system that is activated upon recognition of pathogenic microorganisms or altered self-cells by pattern recognition molecules. Recent evidence suggests that pentraxins cooperate with effector PRMs to enhance complement activation.