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Clinical and Molecular Features of Morpheaform Basal Cell Carcinoma: A Systematic Review

Journal

CURRENT ONCOLOGY
Volume 30, Issue 11, Pages 9906-9928

Publisher

MDPI
DOI: 10.3390/curroncol30110720

Keywords

morpheaform basal cell carcinoma; sclerosing basal cell carcinoma; morphoeic basal cell carcinoma; fibrosing basal cell carcinoma; BCC; skin cancer

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This review explores various features of morpheaform BCC and highlights its poorer prognosis.
Basal cell carcinoma (BCC) is the most common skin cancer, with a lifetime risk currently approaching up to 40% in Caucasians. Among these, some clinical and pathological BCC variants pose a higher risk due to their more aggressive biological behavior. Morpheaform BCC (morBCC), also known as sclerosing, fibrosing, or morpheic BCC, represents up to 5-10% of all BCC. Overall, morBCC carries a poorer prognosis due to late presentation, local tissue destruction, tumor recurrence, and higher frequency of metastasis. In this systematic review, we review the epidemiological, clinical, morphological, dermatoscopical, and molecular features of morBCC. After the title and abstract screening of 222 studies and the full-text review of 84 studies, a total of 54 studies met the inclusion criteria and were thus included in this review.

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