A comprehensive review on nanocomposite biomaterials based on gelatin for bone tissue engineering

The creation of a suitable scaffold is a crucial step in the process of bone tissue engineering (BTE). The scaffold, acting as an artificial extracellular matrix, plays a significant role in determining the fate of cells by affecting their proliferation and differentiation in BTE. Therefore, careful consideration should be given to the fabrication approach and materials used for scaffold preparation. Natural polypeptides such as gelatin and collagen have been widely used for this purpose. The unique properties of nanoparticles, which vary depending on their size, charge, and physicochemical properties, have demonstrated potential in solving various challenges encountered in BTE. Therefore, nanocomposite biomaterials consisting of polymers and nanoparticles have been extensively used for BTE. Gelatin has also been utilized in combination with other nanomaterials to apply for this purpose. Composites of gelatin with various types of nanoparticles are particularly promising for creating scaffolds with superior biological and physicochemical properties. This review explores the use of nanocomposite biomaterials based on gelatin and various types of nanoparticles together for applications in bone tissue engineering.

Automated summary

The creation of a suitable scaffold is crucial in bone tissue engineering, as it affects the fate of cells. Natural polypeptides like gelatin and collagen have been widely used for scaffold preparation. Nanocomposite biomaterials consisting of polymers and nanoparticles have shown potential in addressing challenges in bone tissue engineering. Gelatin combined with various types of nanoparticles is promising for creating scaffolds with superior properties. This review explores the use of nanocomposite biomaterials based on gelatin and nanoparticles in bone tissue engineering applications.