Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Ischemic stroke (IS) remains one of the leading causes of death and disability in humans. Unfortunately, none of the treatments effectively provide functional benefits to patients with IS, although many do so by targeting different aspects of the ischemic cascade response. The advantages of traditional Chinese medicine (TCM) in preventing and treating IS are obvious in terms of early treatment and global coordination. The efficacy of TCM and its bioactive constituents has been scientifically proven over the past decades. Based on clinical trials, this article provides a review of commonly used TCM patent medicines and herbal decoctions indicated for IS. In addition, this paper also reviews the mechanisms of bioactive constituents in TCM for the treatment of IS in recent years, both domestically and internationally. A comprehensive review of preclinical and clinical studies will hopefully provide new ideas to address the threat of IS. This review summarizes the progress of research on TCM and its bioactive constituents in the treatment of IS in terms of both clinical and preclinical evidence.image

Automated summary

Traditional Chinese medicine (TCM) has obvious advantages in preventing and treating ischemic stroke (IS) and is scientifically proven to be effective. This review summarizes commonly used TCM medicines and their mechanisms in the treatment of IS.