Mesenchymal stem cell-based TRAIL delivery inhibits the metastatic state of clinical therapy-resistant progressive neuroblastoma

Article Cell Biology

Prognostic significance of NT5E/CD73 in neuroblastoma and its function in CSC stemness maintenance

Drishti Jain et al.

Summary: High expression of CD73 in neuroblastoma is associated with good prognosis and it also regulates stemness maintenance in cells that resist clinical therapy.

CELL BIOLOGY AND TOXICOLOGY (2023)

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Article Biochemistry & Molecular Biology

Cytochalasin B-Induced Membrane Vesicles from TRAIL-Overexpressing Mesenchymal Stem Cells Induce Extrinsic Pathway of Apoptosis in Breast Cancer Mouse Model

Daria S. S. Chulpanova et al.

Summary: In this study, membrane vesicles (MVs) were isolated from TRAIL-overexpressing mesenchymal stem cells using cytochalasin B treatment (CIMVs). The antitumor effect of CIMVs-TRAIL was evaluated in a breast cancer mouse model, and it was found that CIMVs-TRAIL could activate the extrinsic apoptosis pathway and induce tumor cell death.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2023)

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Article Cell Biology

Sensitizing TRAIL response via differential modulation of anti- and pro-apoptotic factors by AZD5582 combined with ER nanosomal TRAIL in neuroblastoma

Chaohong Huang et al.

Summary: In this study, the combination therapy of ERN-T and AZD5582 showed high efficacy and safety for neuroblastoma, overcoming TRAIL resistance. The concomitant regulation of antiapoptotic and proapoptotic factors and DR5 is crucial for TRAIL sensitization in neuroblastoma. This combination therapy potentially constitutes a novel therapeutic strategy.

ACTA HISTOCHEMICA (2022)

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Letter Pediatrics

ALK expression, prognostic significance, and its association with MYCN expression in MYCN non-amplified neuroblastoma

Dinesh Babu Somasundaram et al.

WORLD JOURNAL OF PEDIATRICS (2022)

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Article Cell Biology

Significance of hematopoietic surface antigen CD34 in neuroblastoma prognosis and the genetic landscape of CD34-expressing neuroblastoma CSCs

Natarajan Aravindan et al.

Summary: Research investigated the role of CD34 in neuroblastoma progression and clinical outcomes, finding associations between CD34 expression and key indicators such as MYCN amplification, disease stage, and disease progression. The expression of CD34 in NB CSCs may influence crucial signaling pathways in the evolution of neuroblastoma.

CELL BIOLOGY AND TOXICOLOGY (2021)

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Article Pediatrics

A Novel Therapeutic Mechanism of Imipridones ONC201/ONC206 in MYCN-Amplified Neuroblastoma Cells via Differential Expression of Tumorigenic Proteins

Sarra El-Soussi et al.

Summary: Neuroblastoma, the most common extracranial nervous system tumor in children, often exhibits MYCN amplification in high-risk cases. Small molecule inducers ONC201 and ONC206 show potent antitumor activity by inhibiting protein phosphorylation in both cell lines.

FRONTIERS IN PEDIATRICS (2021)

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Article Immunology

Secreted TRAIL gene-modified adipose-derived stem cells exhibited potent tumor-suppressive effect in hepatocellular carcinoma cells

Zhuo Liu et al.

Summary: This study explored the impact of TRAIL-modified adipose-derived stem cells (ADSCs) on hepatocellular carcinoma (HCC). The results show that TRAIL-modified ADSCs can effectively inhibit the proliferation and metastasis of HCC, suggesting a potential new approach for HCC treatment.

IMMUNITY INFLAMMATION AND DISEASE (2021)

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Article Multidisciplinary Sciences