Journal
PLOS PATHOGENS
Volume 12, Issue 10, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1005845
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [24117517, 26117719, 16K19117, 16H01365, 25460594, 23406009, 26305013]
- Cooperative Research Grants of NEKKEN
- Grants-in-Aid for Scientific Research [23406009, 26117719, 25460594, 16K19117, 26305013, 16K08842, 24117517, 16H01365] Funding Source: KAKEN
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Amebiasis is caused by Entamoeba histolytica infection and can produce a broad range of clinical signs, from asymptomatic cases to patients with obvious symptoms. The current epidemiological and clinical statuses of amebiasis make it a serious public health problem worldwide. The Entamoeba life cycle consists of the trophozoite, the causative agent for amebiasis, and the cyst, the form responsible for transmission. These two stages are connected by encystation and excystation. Hence, developing novel strategies to control encystation and excystation will potentially lead to new measures to block the transmission of amebiasis by interrupting the life cycle of the causative agent. Here, we highlight studies investigating encystation using inhibitory chemicals and categorize them based on the molecules inhibited. We also present a perspective on new strategies to prevent the transmission of amebiasis.
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