4.7 Article

Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health

Related references

Note: Only part of the references are listed.
Review Nutrition & Dietetics

Gut Microbiota and its Metabolites: Bridge of Dietary Nutrients and Alzheimer's Disease

Guangsu Zhu et al.

Summary: Alzheimer's disease is a neurodegenerative disease characterized by cognitive impairment and neuroinflammation. Recent research has shown the important role of gut microbiota and microbial metabolites in modulating AD, but the mechanisms are still not well understood.

ADVANCES IN NUTRITION (2023)

Review Pharmacology & Pharmacy

Polyphenols and neuroprotection: Therapeutic implications for cognitive decline

Giuseppe Caruso et al.

Summary: Dietary polyphenols have potential therapeutic effects in preventing or ameliorating cognitive decline, although human studies have yielded inconclusive and contrasting results. Anthocyanins consistently showed positive effects, while studies on cocoa flavanols, resveratrol, and isoflavones provided conflicting results. Other polyphenols showed promising but limited evidence.

PHARMACOLOGY & THERAPEUTICS (2022)

Review Nutrition & Dietetics

Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition

Aleix Sala-Vila et al.

Summary: This narrative review updates the evidence on the relationship between dietary alpha-linolenic acid (ALA) and cardiovascular disease, metabolic syndrome, type 2 diabetes, and cognition. There is increasing evidence for the cardiovascular benefits of ALA, but its effects on metabolic syndrome and obesity are inconclusive. Research on the role of ALA in cognition is in the early stages.

ADVANCES IN NUTRITION (2022)

Article Biochemistry & Molecular Biology

Dietary Phytoestrogen Intake and Cognitive Status in Southern Italian Older Adults

Francesca Giampieri et al.

Summary: This study aimed to investigate the association between phytoestrogen intake and cognitive status. The results showed that higher intake of phytoestrogens, especially isoflavones, was associated with better cognitive status.

BIOMOLECULES (2022)

Review Neurosciences

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Emily Connell et al.

Summary: The increasing prevalence of age-related cognitive decline and dementia is a consequence of our ageing global population. The microbiota-gut-brain axis, a dynamic bidirectional communication system between the gut, its microbiome, and the central nervous system, may play a role in cognitive health and disease. Microbial-derived metabolites have been identified as potential risk factors for cognitive decline, impacting cognition through cytotoxic metabolite production, neuroinflammation, and other mechanisms.

MOLECULAR NEURODEGENERATION (2022)

Article Biochemistry & Molecular Biology

One-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes-A Case-Control Study

Maria Marhuenda-Munoz et al.

Summary: The study found that changes in urinary microbial phenolic metabolites were associated with the risk of developing type 2 diabetes. However, when adjusting for fasting plasma glucose, this association lost statistical significance. Changes in dietary patterns may affect the production of metabolites and alter the gut microbial population.

ANTIOXIDANTS (2022)

Review Nutrition & Dietetics

Association between the mediterranean diet and cognitive health among healthy adults: A systematic review and meta-analysis

Jialei Fu et al.

Summary: This systematic review and meta-analysis found that adherence to the Mediterranean (MeDi) diet may lower the risk of cognitive disorders, particularly mild cognitive impairment (MCI) and Alzheimer's disease (AD) in older adults. Additionally, adherence to the MeDi diet may improve working memory and episodic memory. However, further research and interpretation are needed to clarify the associations with other cognitive outcomes.

FRONTIERS IN NUTRITION (2022)

Review Pharmacology & Pharmacy

Advances in the roles and mechanisms of lignans against Alzheimer's disease

Na Han et al.

Summary: This article explores the roles and mechanisms of lignans in the treatment of neurological diseases, providing evidence for the development of lignans as novel anti-AD drugs.

FRONTIERS IN PHARMACOLOGY (2022)

Article Agriculture, Dairy & Animal Science

Dietary ferulic acid and vanillic acid on inflammation, gut barrier function and growth performance in lipopolysaccharide-challenged piglets

Ruizhi Hu et al.

Summary: The study demonstrated that both vanillic acid (VA) and ferulic acid (FA) can alleviate inflammation and oxidative stress, with VA having a significant positive effect on the growth performance of LPS-challenged piglets potentially through modulating gut microbiota.

ANIMAL NUTRITION (2022)

Article Nutrition & Dietetics

Memory enhancement in Argentinian women during postpartum by the dietary intake of lignans and anthocyanins

Agustin R. Miranda et al.

Summary: This study examined the hypothesis that polyphenols from vegetable foods can enhance memory functioning in postpartum women, particularly in the systems of short-term memory, long-term memory, working memory, learning, and lexical-semantic memory. The results showed that lignans and anthocyanins were particularly associated with cognitive improvement in various memory systems among postpartum women, suggesting a potential role of polyphenolic effects on memory during the postpartum period.

NUTRITION RESEARCH (2021)

Article Nutrition & Dietetics

Crosstalk among intestinal barrier, gut microbiota and serum metabolome after a polyphenol-rich diet in older subjects with leaky gut: The MaPLE trial

Gregorio Peron et al.

Summary: The MaPLE study demonstrated that a polyphenol-rich diet reduced intestinal permeability in older adults by altering gut microbiota composition. Changes in serum metabolome were found to be closely related to the complex interactions between dietary polyphenols, gut microbiota, and intestinal barrier. Personalized dietary interventions for older adults should consider these complex relationships.

CLINICAL NUTRITION (2021)

Review Nutrition & Dietetics

Influence of Mediterranean Diet on Human Gut Microbiota

Giuseppe Merra et al.

Summary: Changes in gut microbiota are correlated with health status, with the Mediterranean diet shown to modulate gut microbiota, increase diversity, and potentially prevent the onset of chronic non-communicable degenerative diseases. Additional controlled intervention studies are needed to further understand the correlations between dietary patterns and gut microbiota composition and activity.

NUTRIENTS (2021)

Article Food Science & Technology

Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12-Year Prospective Study

Raul Gonzalez-Dominguez et al.

Summary: This study investigated the association between food-related and microbiota-derived circulating metabolites and cognitive decline in participants free of dementia. Results showed a protective relationship with metabolites from cocoa, coffee, mushrooms, red wine, and polyphenol-rich foods, and a negative association with metabolites related to unhealthy dietary components like artificial sweeteners and alcohol. These findings provide insight into potential targets for preserving cognitive health through diet, gut microbiota, and endogenous metabolism interactions.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

Review Food Science & Technology

Role of dietary polyphenols on gut microbiota, their metabolites and health benefits

S. Mithul Aravind et al.

Summary: In the past two decades, there has been intensive research on the beneficial health roles of dietary polyphenols in preventing oxidative stress related chronic diseases. As our understanding of the role of gut microbiota advances, the need to examine the prebiotic role of dietary polyphenols has emerged. Further research should focus on the importance of human trials and the links of polyphenols-gut microbiota-nerve-brain to unlock the mechanisms behind the observed benefits of dietary polyphenols.

FOOD RESEARCH INTERNATIONAL (2021)

Article Endocrinology & Metabolism

Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follow-up in the PREDIMED-Plus Study

Carlos Gomez-Martinez et al.

Summary: This study found that prediabetes was not associated with cognitive decline, but longer duration of diabetes, insulin resistance, HbA(1c) levels, poor diabetes control, and insulin treatment were related to worsened cognitive function changes in the short term in individuals at high cardiovascular risk.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Nutrition & Dietetics

Validity of the energy-restricted Mediterranean Diet Adherence Screener

Helmut Schroder et al.

Summary: The study found that the 17-item energy-restricted Mediterranean Adherence Screener (er-MEDAS) in the PREDIMED-Plus trial has moderate to good concurrent validity compared with a validated semiquantitative food frequency questionnaire (FFQ). An increase in the er-MEDAS score was associated with improvements in dietary and cardiometabolic profiles over time.

CLINICAL NUTRITION (2021)

Review Biochemistry & Molecular Biology

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Francesco Di Meo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Clinical Neurology

Autonomic Dysfunction in α-Synucleinopathies

Jose Javier Mendoza-Velasquez et al.

FRONTIERS IN NEUROLOGY (2019)

Article Nutrition & Dietetics

Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice

Satomi Shimoyoshi et al.

NUTRIENTS (2019)

Article Public, Environmental & Occupational Health

Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial

Miguel A. Martinez-Gonzalez et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2019)

Article Multidisciplinary Sciences

Vanillic acid attenuates A beta(1-42)-induced oxidative stress and cognitive impairment in mice

Faiz Ul Amin et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

Cyanidin-3-O-glucoside: Physical-Chemistry, Foodomics and Health Effects

Francisco J. Olivas-Aguirre et al.

MOLECULES (2016)

Article Plant Sciences

Cognitive effects of vanillic acid against streptozotocin-induced neurodegeneration in mice

Jayasingh Chellammal Hanish Singh et al.

PHARMACEUTICAL BIOLOGY (2015)

Article Microbiology

Gordonibacter urolithinfaciens sp nov., a urolithin-producing bacterium isolated from the human gut

Maria V. Selma et al.

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2014)

Article Multidisciplinary Sciences

Cognitive Decline in Older Persons Initiating Anticholinergic Medications

Raj C. Shah et al.

PLOS ONE (2013)

Article Obstetrics & Gynecology

Dietary phytoestrogen intakes and cognitive function during the menopausal transition: results from the Study of Women's Health Across the Nation Phytoestrogen Study

Gail A. Greendale et al.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2012)

Article Public, Environmental & Occupational Health

Mediterranean diet pyramid today. Science and cultural updates

Anna Bach-Faig et al.

PUBLIC HEALTH NUTRITION (2011)

Article Clinical Neurology

Longitudinal Assessment of Cognitive Function by Clock Drawing in Older Adults

Annlia Paganini-Hill et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA (2011)

Article Nutrition & Dietetics

Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain

Joan D. Fernandez-Ballarth et al.

BRITISH JOURNAL OF NUTRITION (2010)

Article Food Science & Technology

The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products

Colin D. Kay et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2009)

Article Behavioral Sciences

Clinical validity of the 'mini-mental state' for Spanish speaking communities

R Blesa et al.

NEUROPSYCHOLOGIA (2001)