Journal
PLOS PATHOGENS
Volume 12, Issue 6, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1005708
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Funding
- National Institute of Allergy and Infectious Diseases [AI114075, AI065638]
- National Cancer Institute [CA093678]
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Natural killer (NK) cells produce interferon (IFN)-gamma and thus have been suggested to promote type I immunity during bacterial infections. Yet, Listeria monocytogenes (Lm) and some other pathogens encode proteins that cause increased NK cell activation. Here, we show that stimulation of NK cell activation increases susceptibility during Lm infection despite and independent from robust NK cell production of IFN gamma. The increased susceptibility correlated with IL-10 production by responding NK cells. NK cells produced IL-10 as their IFN. production waned and the Lm virulence protein p60 promoted induction of IL-10 production by mouse and human NK cells. NK cells consequently exerted regulatory effects to suppress accumulation and activation of inflammatory myeloid cells. Our results reveal new dimensions of the role played by NK cells during Lm infection and demonstrate the ability of this bacterial pathogen to exploit the induction of regulatory NK cell activity to increase host susceptibility.
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