☆ 4.6 Review

Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis

CANCERS (2023)

Related references

Note: Only part of the references are listed.

Article Dentistry, Oral Surgery & Medicine

LINC00664/miR-411-5p/KLF9 feedback loop contributes to the human oral squamous cell carcinoma progression

Chengyong Wang et al.

Summary: This study revealed the oncogenic role of LINC00664 in the progression of oral squamous cell carcinoma (OSCC) through the KLF9/LINC00664/miR-411-5p/KLF9 feedback loop. LINC00664 was found to promote cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in OSCC. This provides new perspectives for potential therapeutic targets in OSCC.

ORAL DISEASES (2023)

Add to Collection

Article Endocrinology & Metabolism

Epigenome-Wide Association Study Reveals CpG Sites Associated with Thyroid Function and Regulatory Effects on KLF9

Antoine Weihs et al.

Summary: Novel associations between thyroid hormones and DNA methylation were discovered, advancing our understanding of thyroid hormone action particularly related to KLF9. This study demonstrates the utility of integrating EWAS with other -omics data for unraveling thyroid hormone signaling in humans.

THYROID (2023)

Add to Collection

Review Oncology

Kruppel-like factors in tumors: Key regulators and therapeutic avenues

Yuchen Zhang et al.

Summary: Kruppel-like factors (KLFs) are DNA-binding transcriptional regulators that play essential roles in various cellular processes, including tumor development. They regulate multiple signaling pathways and mediate crosstalk among them, and their abnormal expression is closely associated with tumor cell characteristics and alterations in the tumor microenvironment. The role of each KLF in tumors varies depending on tumor type and stage of development. This review focuses on the molecular biology of KLFs, the regulation of classical signaling pathways by these factors, and their potential as molecular targets in tumor therapy.

FRONTIERS IN ONCOLOGY (2023)

Add to Collection

Article Oncology

Kruppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis

Weand S. Ybanez et al.

Summary: This study investigates the role of KLF9 in breast cancer and the crosstalk between hormone signaling and the circadian molecular network. The findings show that KLF9 is a direct target of the glucocorticoid receptor and its expression is regulated by the circadian rhythm. Furthermore, KLF9 plays a tumor-suppressive role in breast cancer regardless of molecular subtype.

CANCER CELL INTERNATIONAL (2023)

Add to Collection

Article Cell Biology

Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-(3 signaling and fibrosis

Shu Yang et al.

Summary: This study identifies the role of KLF13 in regulating TGF-(3 signaling and fibrosis. KLF13 recruits a repressor complex to the target genes of TGF-(3, limiting its fibrotic effects. However, persistent activation of TGF-(3 signaling reduces KLF13 levels through degradation and transcriptional inhibition mechanisms, offsetting the anti-fibrotic effect of KLF13.

CELL REPORTS (2023)

Add to Collection

Article Oncology

Aberrant Methylation of the Imprinted C19MC and MIR371-3 Clusters in Patients with Non-Small Cell Lung Cancer

Laura Boyero et al.

Summary: Aberrations in DNA methylation profiles of C19MC and MIR371-3 miRNA clusters may affect non-small cell lung cancer by deregulating target genes, leading to poor overall survival. These miRNA clusters play a key role in lung cancer as their epigenetic regulation influences the expression of downstream target genes with prognostic value.

CANCERS (2023)

Add to Collection

Article Medicine, General & Internal

Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth

Rossella Alfano et al.

Summary: This meta-analysis explored the association between cord blood DNA methylation and rapid weight growth in six European child cohorts. The results identified 47 CpG sites and 16 genomic regions that were associated with rapid weight growth. Further analysis revealed that DNA methylation partially mediated the effect of gestational age on rapid weight growth, and was also associated with childhood overweight and prenatal exposures. These findings provide potential opportunities for early prevention and intervention of childhood obesity.

BMC MEDICINE (2023)

Add to Collection

Article Neurosciences

Genomic regulation of Kr?ppel-like-factor family members by corticosteroid receptors in the rat brain

Clare L. M. Kennedy et al.

Summary: Hippocampal mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) play a role in regulating gene expression in response to stress and circadian variation. This study focused on the Kruppel-like factors (KLFs) and found that the MRs and GRs bind to specific sequences within KLF genes in different regions of the brain, leading to increased expression levels. These findings provide insights into the molecular mechanisms underlying the effects of stress and circadian rhythm on brain function.

NEUROBIOLOGY OF STRESS (2023)

Add to Collection

Article Cell Biology

A negative feedback loop between KLF9 and the EMT program dictates metastasis of hepatocellular carcinoma

Tao Wang et al.

Summary: KLF9 is a critical transcription factor that suppresses hepatocellular carcinoma (HCC) metastasis by inhibiting the transcription of mesenchymal genes. The expression of KLF9 is significantly reduced in metastatic HCC. Clinical samples show that KLF9 is downregulated in HCC tissues compared to normal counterparts and further reduced in samples with metastatic lesions. Therefore, KLF9 is of clinical and mechanistic significance in HCC therapies.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2023)

Add to Collection

Article Oncology

The circadian clock, aging and its implications in cancer

Abdol-Hossein Rezaeian et al.

Summary: The circadian clock regulates 24-hour oscillations in biochemical, physiological, and behavioral changes through the transcription-translation feedback loop. The transcriptional activator heterodimer of BMAL1 and CLOCK controls the expression of its repressors, CRY, PER, and REV-ERB alpha/beta proteins, which regulate more than 50% of protein encoding genes in humans. The tumor microenvironment can disrupt clock gene functions and promote tumorigenesis. Understanding the relationships between the circadian clock, aging, and cancer is challenging.

NEOPLASIA (2023)

Add to Collection

Article Multidisciplinary Sciences

CCL5 might be a prognostic biomarker and associated with immuno-therapeutic efficacy in cancers: A pan-cancer analysis

Yanchun Huang et al.

Summary: This study conducted a comprehensive pan-cancer analysis to explore the value of CCL5 in patient prognosis. The results showed that CCL5 was overexpressed in most tumors and significantly associated with clinical prognosis in 10 out of 33 types of tumors. CCL5 was found to be related to tumor mutational burden, DNA methylation, immune infiltration, immune checkpoints, and cytokine signaling, indicating its potential role in tumor pathogenesis and prognosis.

HELIYON (2023)

Add to Collection

Article Multidisciplinary Sciences

Loss of Kruppel-like factor 9 deregulates both physiological gene expression and development

Laura Drepanos et al.

Summary: Klf9 is a transcription factor that regulates multiple stress-responsive and endocrine signaling pathways. We investigated the transcriptomic effects of the klf9(-/-) mutation at different timepoints and found additional effects that only manifest at the predawn time point. The mutation increased mRNA associated with digestive organs and decreased mRNA associated with differentiating neurons and blood.

SCIENTIFIC REPORTS (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression

Shuang Liu et al.

Summary: This study investigates the regulatory mechanisms of bile acid (BA) in the intestine. It reveals that Krüppel-like factor 9 (Klf9) enhances BA absorption in the intestine by promoting the expression of apical sodium-dependent bile acid transporter (Asbt), thereby affecting BA levels in the gallbladder, faeces, and serum. Klf9 also regulates liver BA synthetic enzymes by regulating Fgf15 expression.

ACTA PHARMACOLOGICA SINICA (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Ghrelin attenuates transforming growth factor-β1-induced pulmonary fibrosis via the miR-125a-5p/Kruppel-like factor 13 axis

Jing Qiu et al.

Summary: Ghrelin exerts protective effects against TGF-beta 1-induced pulmonary fibrosis by attenuating fibrotic responses and downregulating smad2/3 through the miR-125a-5p/KLF13 axis, highlighting its potential as a new therapeutic agent against this condition.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2022)

Add to Collection

Article Oncology

The inhibitory effect of LINC00261 upregulation on the pancreatic cancer EMT process is mediated by KLF13 via the mTOR signaling pathway

B. Li et al.

Summary: This study identifies LINC00261 as a tumor suppressor in pancreatic cancer, which is mainly localized in the nucleus. Mechanistically, transcription factor KLF13 promotes the transcription of LINC00261 and suppresses metastasis-associated proteins, inhibiting the metastasis of pancreatic cancer cells through the KLF13-LINC00261-mTOR-P70S6K1-S6 signaling pathway.

CLINICAL & TRANSLATIONAL ONCOLOGY (2022)

Add to Collection

Article Oncology

Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A-PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1

Rama Kadamb et al.

Summary: In this study, specific disruption of the PF1/SIN3A interaction was found to inhibit tumor growth, migration, and invasion in triple negative breast cancer. This disruption also led to senescence induction and reduced proliferation, targeting cancer stem cell gene expression and blocking mammosphere formation. The presence of SIN3A and transcriptional repressor KLF9 on the promoters of ITGA6 and ITGB1 in PF1-SID cells suggests a mechanism of suppression of invasion and metastasis.

TRANSLATIONAL ONCOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Human transcription factor protein interaction networks

Helka Goos et al.

Summary: This study identifies protein-protein interactions for 109 different human transcription factors using BioID and AP-MS analyses, resulting in a rich resource of TF interactions. The analysis reveals the transient and dynamic nature of TF interactions and identifies subgroups of TFs associated with specific biological functions. Additionally, uncharacterized cross-talk between NFI signaling and other TF signaling pathways is observed.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Biology

Transcriptional regulation of neural stem cell expansion in the adult hippocampus

Nannan Guo et al.

Summary: This study reveals that the transcription factor Klf9 functions as a brake on symmetric self-renewal of radial-glial neural stem cells (RGLs) in mice. The loss of Klf9 promotes the activation state of RGLs and leads to increased symmetric self-renewal. The study also provides molecular insights into the genetic programs underlying RGL symmetric self-renewal, including Notch and mitogen signaling, cell cycle, fatty acid oxidation, and lipogenesis.

ELIFE (2022)

Add to Collection

Article Oncology

Predicting 3D Structure, Cross Talks, and Prognostic Significance of KLF9 in Cervical Cancer

Sadia Safi et al.

Summary: This study aimed to identify new blood-based biomarkers for the diagnosis and prognosis of cervical cancer. The research also determined the 3D structure of KLF9 to better understand its function. The study revealed a possible relation between the co-expressions of TPD52, KLF9, miR-223, and PKC epsilon and the outcome of cervical cancer.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Article Cell Biology

Kruppel-like factors in bone biology

Sina Zakeri et al.

Summary: This review summarizes the important functions of the KLF family in skeletal development, including their roles in stem cell maintenance and differentiation, cell apoptosis, and cell cycle. It also discusses the genotype-phenotype correlations in animal models and explores how KLF proteins function through different signaling pathways. Additionally, the review highlights the roles of KLF family in cartilage- and bone-related cells and challenges our understanding of its epigenetic regulation during chondrocyte and osteocyte development.

CELLULAR SIGNALLING (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

KLF16 enhances stress tolerance of colorectal carcinomas by modulating nucleolar homeostasis and translational reprogramming

Xiao-Dan Ma et al.

Summary: This study reveals a previously unrecognized role for KLF16 as an ER stress regulator through mediating translational reprogramming, enhancing the stress tolerance of CRC cells and providing a potential therapeutic vulnerability.

MOLECULAR THERAPY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Search and sequence analysis tools services from EMBL-EBI in 2022

Fabio Madeira et al.

Summary: The EMBL-EBI search and sequence analysis tools frameworks allow integrated access to data resources and core bioinformatics analytical tools. These tools can be interacted with through user-friendly web applications and APIs. Recent improvements have been made to accommodate the increasing data requirements during the COVID-19 pandemic.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection

Article Cell Biology

Mxi1 participates in the progression of lung cancer via the microRNA-300/KLF9/GADD34 Axis

Yujie Lei et al.

Summary: The study aims to investigate the role and molecular mechanism of MAX interactor 1 (Mxi1) in the pathogenesis of lung cancer. The results show that Mxi1 inhibits the progression of lung cancer by suppressing the expression of miR-300 and regulating the expression of KLF9 and GADD34. These findings reveal a potential target for the treatment of lung cancer.

CELL DEATH & DISEASE (2022)

Add to Collection

Article Medicine, Research & Experimental

A novel KLF13 mutation underlying congenital patent ductus arteriosus and ventricular septal defect, as well as bicuspid aortic valve

Pradhan Abhinav et al.

Summary: This study identified a new mutation in the KLF13 gene that is associated with familial PDA, VSD, and BAV. The findings expand the phenotypic spectrum linked to KLF13 and reveal a novel molecular pathogenesis of the disease.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

Add to Collection

Article Reproductive Biology

miR-600 promotes ovarian cancer cells stemness, proliferation and metastasis via targeting KLF9

Lili Shan et al.

Summary: Previous studies have shown that miR-600 plays a role in the pathogenesis of ovarian cancer. This study further demonstrates that miR-600 promotes stemness, proliferation, and metastasis of ovarian cancer cells by directly downregulating KLF9 expression.

JOURNAL OF OVARIAN RESEARCH (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Kruppel like factor 16 promotes lung adenocarcinoma progression by upregulating lamin B2

Xiaodan Jiao et al.

Summary: KLF16 plays a critical role in lung cancer cell proliferation and migration by regulating the expression of the LMNB2 gene.

BIOENGINEERED (2022)

Add to Collection

Article Oncology

Kruppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet

Adam R. Brown et al.

Summary: The study revealed that KLF9 acts as a suppressor of liver oxidative stress and inflammation, potentially explaining its tumor-suppressing effects in various tissues.

CANCERS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Kruppel-like Factors in Skeletal Physiology and Pathologies

Makoto Abe et al.

Summary: Kruppel-like factors (KLFs), a group of zinc finger-containing transcription factors, play crucial roles in transcription regulation, cell proliferation, cellular differentiation, stem cell maintenance, and tissue and organ pathogenesis. Recent studies have shown that KLF family molecules have significant effects on skeletal cells, influencing their differentiation and function. This review provides an overview of the unique roles of each KLF in skeletal cells during normal development and skeletal pathologies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Public, Environmental & Occupational Health

The association between endometriosis and risk of endometrial cancer and breast cancer: a meta-analysis

Jiatian Ye et al.

Summary: This study, through a meta-analysis, found that endometriosis can increase the risk of endometrial cancer and breast cancer. Women with endometriosis are recommended to receive routine screening.

BMC WOMENS HEALTH (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

KLF13 Loss-of-Function Mutations Underlying Familial Dilated Cardiomyopathy

Yu-Han Guo et al.

Summary: This study identified a new gene locus for DCM and identified three mutations associated with DCM. The findings provide novel insights into the molecular pathogenesis of DCM and have potential implications for prenatal prevention and precision treatment in a subset of patients.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

Add to Collection

Article Oncology

Low expression of PEBP1P2 promotes metastasis of clear cell renal cell carcinoma by post-transcriptional regulation of PEBP1 and KLF13 mRNA

Lei Yang et al.

Summary: PEBP1P2 inhibits ccRCC metastasis formation and regulates both PEBP1 and KLF13. Therefore, molecular therapies targeting PEBP1P2 might be an effective treatment strategy against ccRCC and other cancers with low PEBP1P2 levels.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Circular RNA_0078767 upregulates Kruppel-like factor 9 expression by targeting microRNA-889, thereby inhibiting the progression of osteosarcoma

Qiu Chen et al.

Summary: This study identified the biological functions of circ_0078767 in osteosarcoma and its molecular mechanisms. It was found that circ_0078767 expression was reduced in OS cells and tissues. Circ_0078767 overexpression inhibited OS progression by targeting miR-889 and enhancing KLF9 expression.

BIOENGINEERED (2022)

Add to Collection

Article Oncology

Kruppel-like factor 13 inhibits cell proliferation of gastric cancer by inducing autophagic degradation of β-catenin

Youxiang Ding et al.

Summary: It is found that KLF13 expression is significantly decreased in gastric cancer tissues and cells, and KLF13 inhibits gastric cancer proliferation by promoting autophagic degradation of beta-catenin.

DISCOVER ONCOLOGY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

SP and KLF Transcription Factors in Cancer Metabolism

Emilia J. Orzechowska-Licari et al.

Summary: Tumor development and progression rely on the reprogramming of signaling pathways that regulate cell metabolism, with transcription factors SP and KLF playing crucial roles in modulating these alterations and thus impacting tumorigenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF

Celine Bernhardt et al.

Summary: KLF9 and KLF13 are important and largely redundant components of the gene regulatory network in charge of oligodendrocyte differentiation and myelination, as they enhance differentiation and promote myelin formation.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection

Article Genetics & Heredity

A novel necroptosis-related gene signature associated with immune landscape for predicting the prognosis of papillary thyroid cancer

Zhiyuan Wang et al.

Summary: A risk signature consisting of seven necroptosis-related genes was constructed to predict the prognosis of papillary thyroid cancer (PTC) patients. Patients in the high-risk group had worse overall survival, while those in the low-risk group showed better outcomes, demonstrating the predictive capability of the signature.

FRONTIERS IN GENETICS (2022)

Add to Collection

Article Cell Biology

KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARγ/NRF2 Signalling

Fangfang Li et al.

Summary: This study reveals that KLF9 exacerbates cardiac dysfunction, inflammatory response, and oxidative stress in diabetic cardiomyopathy. KLF9 may be a potential therapeutic target for diabetic cardiomyopathy.

CELLS (2022)

Add to Collection

Article Medicine, General & Internal

Prognostic value and immunological role of Kruppel-like transcription factor 9 gene in pan-carcinoma

Weichao Cai et al.

Summary: The expression of KLF9 is associated with tumor prognosis and immune invasion. Low expression of KLF9 may lead to poor tumor prognosis, while its expression is positively correlated with immune cell infiltration. Therefore, KLF9 may serve as a potential biomarker for tumor prognosis.

MEDICINE (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Effects and Prognostic Values of Circadian Genes CSNK1E/GNA11/KLF9/THRAP3 in Kidney Renal Clear Cell Carcinoma via a Comprehensive Analysis

Shujing Li et al.

Summary: This study identified differentially expressed circadian genes in KIRC and explored their role in KIRC progression. It was found that CSNK1E had higher expression levels associated with shorter overall survival, while GNA11, KLF9, and THRAP3 had lower expression levels associated with shorter overall survival. The study also revealed the association between the expression levels of these circadian genes and immune cell infiltration and immunological biomarkers in KIRC.

BIOENGINEERING-BASEL (2022)

Add to Collection

Article Oncology

KLF9 regulates miR-338-3p/NRCAM axis to block the progression of osteosarcoma cells

Yunlu Liu et al.

Summary: miR-338-3p is downregulated in osteosarcoma and overexpression of miR-338-3p suppresses proliferative, invasive, and migratory abilities of osteosarcoma cells. Moreover, overexpression of NRCAM reduces the anti-tumor role of miR-338-3p in osteosarcoma cells. In addition, overexpression of KLF9 enhances the expression level of miR-338-3p in osteosarcoma cells.

JOURNAL OF CANCER (2022)

Add to Collection

Article Endocrinology & Metabolism

Epigenome-Wide Association Study of Thyroid Function Traits Identifies Novel Associations of fT3 With KLF9 and DOT1L

Nicole Lafontaine et al.

Summary: This study identified associations between blood-based DNAm and both fT3 and TSH, shedding light on the mechanisms underlying thyroid hormone action and/or pituitary-thyroid axis function.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Add to Collection

Article Biochemistry & Molecular Biology

ZZEF1 is a Histone Reader and Transcriptional Coregulator of Kruppel-Like Factors

Yucong Yu et al.

Summary: ZZEF1, a multidomain-containing protein, acts as a histone H3 reader and is involved in gene regulation, especially in association with KLF9/6.

JOURNAL OF MOLECULAR BIOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

New insights of Kruppel-like transcription factors in adipogenesis and the role of their regulatory neighbors

Wylly Ramses Garcia-Nino et al.

Summary: Obesity is a significant public health issue linked to metabolic diseases, with KLFs playing a crucial role in regulating adipogenesis. Understanding adipocyte and adipose tissue development can offer insights for therapeutic strategies against obesity. The review focuses on the transcriptional role of KLF family members in adipocyte differentiation, highlighting interactions with various regulators and potential therapeutic targets.

LIFE SCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

MethHC 2.0: information repository of DNA methylation and gene expression in human cancer

Hsi-Yuan Huang et al.

Summary: This study updated MethHC 2.0 by incorporating additional DNA methylomes and transcriptomes from various public repositories, providing enhanced data annotation functionality and a user-friendly web interface.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Article Cell Biology

KLF9 regulates PRDX6 expression in hyperglycemia-aggravated bupivacaine neurotoxicity

Hui Li et al.

Summary: This study revealed that under hyperglycemic conditions, upregulation of KLF9 repressed the antioxidant PRDX6, resulting in mitochondrial dysfunction, ROS burst, and cell death induced by local anesthetics. Understanding this mechanism could provide valuable insights for the prevention and treatment of neurotoxicity induced by LAs, especially in diabetic patients.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Add to Collection

Article Oncology

miR-483-3p, Mediated by KLF9, Functions as Tumor Suppressor in Testicular Seminoma via Targeting MMP9

Lei Zhang et al.

Summary: miR-483-3p is down-regulated in SEM tissues and significantly associated with tumor stage. Over-expression of miR-483-3p inhibits cell growth, migration, and invasion in SEM cell lines by targeting MMP9. KLF9 acts as an upstream positive regulator of miR-483-3p and functions as a tumor suppressor in SEM.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Article Cell Biology

NRF2-mediated signaling is a master regulator of transcription factors in bovine granulosa cells under oxidative stress condition

Mohamed Omar Taqi et al.

Summary: This study found that bovine granulosa cells exposed to oxidative stress induced by H2O2 exhibited differential expression of various transcription factors, which are mediated by the NRF2 signaling pathway.

CELL AND TISSUE RESEARCH (2021)

Add to Collection

Article Oncology

Acyl-CoA Thioesterase 7 is Transcriptionally Activated by Kruppel-Like Factor 13 and Promotes the Progression of Hepatocellular Carcinoma

Xingming Xie et al.

Summary: The study found that the overexpression of ACOT7 in HCC enhances cell proliferation and migration abilities, and is associated with poor prognosis. KLF13 acts as an upstream regulator of ACOT7 and also overexpressed in HCC tissues, promoting HCC progression.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

Add to Collection

Article Multidisciplinary Sciences

A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic liver disease

Hong Yang et al.

Summary: Researchers conducted network analysis and integrative systems analysis to reveal key transcriptional regulators and biological processes involved in the progression of NAFLD, enhancing the understanding of the disease mechanism.

ISCIENCE (2021)

Add to Collection

Article Oncology

Loss of Kruppel-like factor 9 facilitates stemness in ovarian cancer ascites-derived multicellular spheroids via Notch1/slug signaling

Kun Wang et al.

Summary: This study elucidated the cancer stem cell (CSC) properties of multicellular spheroids/aggregates (MCSs/MCAs) derived from ascites in advanced ovarian cancer, showing enhanced malignancy, induced EMT, and low KLF9 expression compared to primary tumor cells (PTCs). KLF9 negatively modulated stem-like properties in OC cells by reducing Notch1 expression, and its loss predicted poor prognosis in ovarian cancer.

CANCER SCIENCE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Spatially organized multicellular immune hubs in human colorectal cancer

Karin Pelka et al.

Summary: By analyzing the transcriptional profiles of cells in tumors, differences in immune responses between mismatch repair-deficient (MMRd) and mismatch repair-proficient (MMRp) tumors were identified, as well as the logic behind the interaction of malignant and immune cells discovered within tumors.

CELL (2021)

Add to Collection

Article Oncology

Long non-coding RNA DANCR represses the viability, migration and invasion of multiple myeloma cells by sponging miR-135b-5p to target KLF9

Linlin Wu et al.

Summary: In multiple myeloma (MM) patients and cells, the expression of lncRNA DANCR and KLF9 was found to be downregulated, while miR-135b-5p was upregulated. DANCR indirectly regulated KLF9 by sponging miR-135b-5p, thereby suppressing the viability, migration, and invasion of MM cells.

MOLECULAR MEDICINE REPORTS (2021)

Add to Collection

Article Cell Biology

G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production

Huiqing Liu et al.

Summary: The overexpression of GPR17 in glioma cells inhibits cell proliferation, induces apoptosis, and decreases tumorigenic potential. By inhibiting transcription of RNF2, GPR17 reduces histone monoubiquitination and affects the function of KLF9 in glioma cells. Activation of GPR17 can suppress glioma formation, making it a potential therapeutic target.

CELL DEATH & DISEASE (2021)

Add to Collection

Article Multidisciplinary Sciences

Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma

Yun-Fan Sun et al.

Summary: This study used single-cell RNA sequencing to analyze circulating tumor cells from liver cancer patients, revealing that the transcriptional dynamics of CTCs are associated with stress response, cell cycle, and immune evasion signaling. Additionally, it was identified that CCL5 plays a crucial role in immune evasion of CTCs.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Physiology

Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice

Melissa E. Heard-Lipsmeyer et al.

Summary: Endometriosis is a chronic gynecologic disorder affected by genetic and environmental factors. Research suggests that a high-fat diet may reduce lesion incidence and numbers, but the effect varies depending on lesion genotype. These findings could be significant in providing nutritional guidelines for women with or predisposed to endometriosis.

FRONTIERS IN PHYSIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

KLF9 suppresses cell growth and induces apoptosis via the AR pathway in androgen-dependent prostate cancer cells

Pengliang Shen et al.

Summary: Kruppel-like factors (KLFs) play a key role in biological processes like cell proliferation, differentiation, and development. Lower levels of KLF9 were observed in androgen-independent cell lines compared to androgen-dependent cells, with forced overexpression of KLF9 leading to suppressed cell growth and induction of apoptosis in androgen-dependent cells through the AR pathway. These findings suggest that KLF9 may be a potential target for prevention and therapy in the transition from androgen-dependent to androgen-independent prostate cancer.

BIOCHEMISTRY AND BIOPHYSICS REPORTS (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

KLF9 (Kruppel Like Factor 9) induced PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3) downregulation inhibits the proliferation, metastasis and aerobic glycolysis of cutaneous squamous cell carcinoma cells

Jiahua Xing et al.

Summary: Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer in humans with increasing incidence. In this study, the researchers focused on the effects of krueppel-like factor 9 (KLF9) on the progression of CSCC cells by binding to PFKFB3. The results showed that PFKFB3 expression was elevated in CSCC cells compared with HaCaT, and its knockdown inhibited the proliferation, metastasis, and aerobic glycolysis of CSCC cells. Additionally, KLF9 was found to bind to PFKFB3, and downregulation of KLF9 compromised the inhibitory effect of PFKFB3 knockdown on CSCC cell proliferation, metastasis, and aerobic glycolysis.

BIOENGINEERED (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells

Mahmoud M. Mostafa et al.

Summary: The ligand-activated glucocorticoid receptor (GR) can induce variable responses in different cell types, but certain genes like KLF9 show conserved responses. Through experiments and sequencing, it was found that glucocorticoids induce KLF9 expression through multiple specific binding sites, with interactions between these sites and the transcription start site correlating with KLF9 induction. Mechanistic insights gained from cell lines were shown to translate to physiologically relevant systems, highlighting the importance of understanding the regulatory mechanisms of glucocorticoid-mediated gene expression.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Add to Collection

Article Oncology

Kruppel-like factor 9 promotes neuroblastoma differentiation via targeting the sonic hedgehog signaling pathway

Sheng Chen et al.

PEDIATRIC BLOOD & CANCER (2020)

Add to Collection

Review Medicine, Research & Experimental

Kruppel-like factors in breast cancer: Function, regulation and clinical relevance

Jianping Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Article Gastroenterology & Hepatology

Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming

Marta Anna Kowalik et al.

JOURNAL OF HEPATOLOGY (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

KLF16 Affects the MYC Signature and Tumor Growth in Prostate Cancer

Jun Zhang et al.

ONCOTARGETS AND THERAPY (2020)

Add to Collection

Article Biology

The Paralogous Kruppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp

Joseph R. Knoedler et al.

JOURNAL OF BIOLOGICAL RHYTHMS (2020)

Add to Collection

Article Oncology

Expression of Kruppel-like factor 9 in breast cancer patients and its effect on prognosis

Zirong Jiang et al.

ONCOLOGY LETTERS (2020)

Add to Collection

Article Oncology

Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Kruppel-like factor 9

Xiaofang Yan et al.

TRANSLATIONAL CANCER RESEARCH (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The miR-140-5p/KLF9/KCNQ1 axis promotes the progression of renal cell carcinoma

Chenchen Huang et al.

FASEB JOURNAL (2020)

Add to Collection

Article Oncology

The Clinical Relevance and Function of Kruppel-Like Factor 16 in Breast Cancer

Soyeon Bang et al.

CANCER MANAGEMENT AND RESEARCH (2020)

Add to Collection

Article Neurosciences

Molecular Mechanisms for Kruppel-Like Factor 13 Actions in Hippocampal Neurons

Jose avila-Mendoza et al.

MOLECULAR NEUROBIOLOGY (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

CircNOL10 Acts as a Sponge of miR-135a/b-5p in Suppressing Colorectal Cancer Progression via Regulating KLF9

Yuhao Zhang et al.

ONCOTARGETS AND THERAPY (2020)

Add to Collection

Article Multidisciplinary Sciences

Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity

Ian Gans et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

KLF13 suppresses the proliferation and growth of colorectal cancer cells through transcriptionally inhibiting HMGCS1-mediated cholesterol biosynthesis

Weilong Yao et al.

CELL AND BIOSCIENCE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Recent Discoveries on the Involvement of Kruppel-Like Factor 4 in the Most Common Cancer Types

Agnieszka Taracha-Wisniewska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Article Neurosciences

Kruppel-Like Factors 9 and 13 Block Axon Growth by Transcriptional Repression of Key Components of the cAMP Signaling Pathway

Jose Avila-Mendoza et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Add to Collection

Article Genetics & Heredity

Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

Mahmoud M. Mostafa et al.

BMC MEDICAL GENOMICS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

KLF9 suppresses gastric cancer cell invasion and metastasis through transcriptional inhibition of MMP28

Yang Li et al.

FASEB JOURNAL (2019)

Add to Collection

Article Fisheries

Molecular cloning and characterization of grouper Kruppel-like factor 9 gene: Involvement in the fish immune response to viral infection

Yepin Yu et al.

FISH & SHELLFISH IMMUNOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

THBS4 predicts poor outcomes and promotes proliferation and metastasis in gastric cancer

Xiangbo Chen et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Downregulation of KLF13 through DNMTI-mediated hypermethylation promotes glioma cell proliferation and invasion

Rile Wu et al.

ONCOTARGETS AND THERAPY (2019)

Add to Collection

Review Cell & Tissue Engineering

Concise Review: Regulation of Self-Renewal in Normal and Malignant Hematopoietic Stem Cells by Kruppel-Like Factor 4

Chun S. Park et al.

STEM CELLS TRANSLATIONAL MEDICINE (2019)

Add to Collection

Article Genetics & Heredity

MiR-889 promotes cell growth in human non-small cell lung cancer by regulating KLF9

Xu Han et al.

GENE (2019)

Add to Collection

Article Medicine, Research & Experimental

Dexamethasone-induced Kruppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia

Anfang Cui et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Add to Collection

Article Genetics & Heredity

Similarity regression predicts evolution of transcription factor sequence specificity

Samuel A. Lambert et al.

NATURE GENETICS (2019)

Add to Collection

Article Oncology

Prognosis Prediction of Colorectal Cancer Using Gene Expression Profiles

Feixia Pan et al.

FRONTIERS IN ONCOLOGY (2019)

Add to Collection

Article Medicine, Research & Experimental

The antibiotic clofoctol suppresses glioma stem cell proliferation by activating KLF13

Yan Hu et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Add to Collection

Article Dermatology

Transcriptomic Network Interactions in Human Skin Treated with Topical Glucocorticoid Clobetasol Propionate

Loukia N. Lili et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

Add to Collection

Article Medicine, Research & Experimental

KLF9 aggravates ischemic injury in cardiomyocytes through augmenting oxidative stress

Quanneng Yan et al.

LIFE SCIENCES (2019)

Add to Collection

Article Cell Biology

Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells

Bhavana Chhunchha et al.

CELLS (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer

Lei Wang et al.

ONCOTARGETS AND THERAPY (2019)

Add to Collection

Article Cell Biology

CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and upregulating KLF9

Qingqing He et al.

AGING-US (2019)

Add to Collection

Review Endocrinology & Metabolism

The Kruppel-Like Factors and Control of Energy Homeostasis

Paishiun N. Hsieh et al.

ENDOCRINE REVIEWS (2019)

Add to Collection

Article Oncology

Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress-Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer

Rozita Bagheri-Yarmand et al.

MOLECULAR CANCER RESEARCH (2019)

Add to Collection

Article Biochemistry & Molecular Biology

KLF9-dependent ROS regulate melanoma progression in stage-specific manner

Archis Bagati et al.

ONCOGENE (2019)

Add to Collection

Article Endocrinology & Metabolism

Thyroid Hormone Protects Primary Cortical Neurons Exposed to Hypoxia by Reducing DNA Methylation and Apoptosis

Jianrong Li et al.

ENDOCRINOLOGY (2019)

Add to Collection

Review Endocrinology & Metabolism

Epithelial Mutations in Endometriosis: Link to Ovarian Cancer

Serdar E. Bulun et al.

ENDOCRINOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Kruppel-like factor 9 suppressed tumorigenicity of the pancreatic ductal adenocarcinoma by negatively regulating frizzled-5

Peiyu Ji et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

MiR-378 promotes the cell proliferation of osteosarcoma through down-regulating the expression of Kruppel-like factor 9

Ningning Peng et al.

BIOCHEMISTRY AND CELL BIOLOGY (2018)

Add to Collection

Article Oncology

Transcription factor KLF13 inhibits AKT activation and suppresses the growth of prostate carcinoma cells

Qiang Wang et al.

CANCER BIOMARKERS (2018)

Add to Collection

Article Oncology

Kruppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion

Xiao-Yan Bai et al.

CANCER LETTERS (2018)

Add to Collection

Article Oncology

Programmed cell death ligand-1 protein expression and CD274/PD-L1 gene amplification in colorectal cancer: Implications for prognosis

Kyu Sang Lee et al.

CANCER SCIENCE (2018)

Add to Collection

Article Genetics & Heredity

Integrated analysis of gene expression signatures associated with colon cancer from three datasets

Ping Gao et al.

GENE (2018)

Add to Collection

Article Cell Biology

Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses

Antoine Besnard et al.

CELL REPORTS (2018)

Add to Collection

Article Multidisciplinary Sciences

Identification of KLF9 and BCL3 as transcription factors that enhance reprogramming of primordial germ cells

Kei Otsuka et al.

PLOS ONE (2018)

Add to Collection

Article Multidisciplinary Sciences

Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice

Lorenzo M. Fernandes et al.

SCIENTIFIC REPORTS (2018)

Add to Collection

Article Cell Biology

LncRNA CDKN2BAS predicts poor prognosis in patients with hepatocellular carcinoma and promotes metastasis via the miR-153-5p/ARHGAP18 signaling axis

Junzheng Chen et al.

AGING-US (2018)

Add to Collection

Article Oncology

Kruppel-like factor 9 and histone deacetylase inhibitors synergistically induce cell death in glioblastoma stem-like cells

Brian Tung et al.

BMC CANCER (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Angiotensin II induces oxidative stress and upregulates neuroprotective signaling from the NRF2 and KLF9 pathway in dopaminergic cells

Juan A. Parga et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Add to Collection

Article Cell Biology

XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response

Emily E. Fink et al.

CELL REPORTS (2018)

Add to Collection

Article Endocrinology & Metabolism

Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis

Dustin M. Brown et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2018)

Add to Collection

Review Cardiac & Cardiovascular Systems

Kruppel-Like Factors in Metabolic Homeostasis and Cardiometabolic Disease

Yumiko Oishi et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Activation of the Nrf2 Signaling Pathway Involving KLF9 Plays a Critical Role in Allicin Resisting Against Arsenic Trioxide-Induced Hepatotoxicity in Rats

Daqian Yang et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2017)

Add to Collection

Review Gastroenterology & Hepatology

SP and KLF Transcription Factors in Digestive Physiology and Diseases

Chang-Kyung Kim et al.

GASTROENTEROLOGY (2017)

Add to Collection

Article Endocrinology & Metabolism

In-vivo regulation of Kruppel-like factor 9 by corticosteroids and their receptors across tissues in tadpoles of Xenopus tropicalis

Leena H. Shewade et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5

Rami Darwich et al.

HUMAN MOLECULAR GENETICS (2017)

Add to Collection

Article Endocrinology & Metabolism

A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels

L. Wiemerslage et al.

INTERNATIONAL JOURNAL OF OBESITY (2017)

Add to Collection

Article Neurosciences

KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS

Akintomide Apara et al.

JOURNAL OF NEUROSCIENCE (2017)

Add to Collection

Article Multidisciplinary Sciences

Obesity-related CpG Methylation (cg07814318) of Kruppel-like Factor-13 (KLF13) Gene with Childhood Obesity and its cis-Methylation Quantitative Loci

In-Uk Koh et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Hematology

Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis

Ying Zhang et al.

BLOOD (2017)

Add to Collection

Review Cardiac & Cardiovascular Systems

The role of Kruppel-like factor 14 in the pathogenesis of atherosclerosis

Wei Xie et al.

ATHEROSCLEROSIS (2017)

Add to Collection

Article Biotechnology & Applied Microbiology

The Kruppel-like factor 9 cistrome in mouse hippocampal neurons reveals predominant transcriptional repression via proximal promoter binding

Joseph R. Knoedler et al.

BMC GENOMICS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

MiR-141-3p promotes prostate cancer cell proliferation through inhibiting kruppel-like factor-9 expression

Jiu-zhi Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Kruppel-like factor 9 was down-regulated in esophageal squamous cell carcinoma and negatively regulated beta-catenin/TCF signaling

Fan Qiao et al.

MOLECULAR CARCINOGENESIS (2016)

Add to Collection

Article Endocrinology & Metabolism

High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status

Melissa E. Heard et al.

ENDOCRINOLOGY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Kruppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death

Diana Cruz-Topete et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8

W. Zhang et al.

ONCOGENE (2016)

Add to Collection

Article Oncology

Analysis of clock gene-miRNA correlation networks reveals candidate drivers in colorectal cancer

Gianluigi Mazzoccoli et al.

ONCOTARGET (2016)

Add to Collection

Article Biochemistry & Molecular Biology

KLF5 is involved in regulation of IFITM1, 2, and 3 genes during H5N1 virus infection in A549 cells

H-F Wang et al.

CELLULAR AND MOLECULAR BIOLOGY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

The activation of peroxisome proliferator-activated receptor γ is regulated by Kruppel-like transcription factors 6 & 9 under steatotic conditions

Ivonne Escalona-Nandez et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Add to Collection

Article Reproductive Biology

Kruppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis

Melissa E. Heard et al.

BIOLOGY OF REPRODUCTION (2015)

Add to Collection

Article Oncology

Kruppel-like factor 9 inhibits glioma cell proliferation and tumorigenicity via downregulation of miR-21

Shuyun Huang et al.

CANCER LETTERS (2015)

Add to Collection

Article Oncology

Kruppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling

Adam R. Brown et al.

CARCINOGENESIS (2015)

Add to Collection

Article Evolutionary Biology

KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes

Jason S. Presnell et al.

GENOME BIOLOGY AND EVOLUTION (2015)

Add to Collection

Review Endocrinology & Metabolism

The Kruppel-like factors in female reproductive system pathologies

Rosalia C. M. Simmen et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2015)

Add to Collection

Article Oncology

Involvement of Kruppel-like factor 9 in bleomycin-induced pulmonary toxicity

Yue Gu et al.

MOLECULAR MEDICINE REPORTS (2015)

Add to Collection

Article Cell & Tissue Engineering

A Thyroid Hormone Receptor/KLF9 Axis in Human Hepatocytes and Pluripotent Stem Cells

Aleksandra Cvoro et al.

STEM CELLS (2015)

Add to Collection

Article Biochemistry & Molecular Biology

KLF13 promotes porcine adipocyte differentiation through PPARγ activation

Shuzhong Jiang et al.

CELL AND BIOSCIENCE (2015)

Add to Collection

Article Obstetrics & Gynecology

Lentivirus-mediated knockdown of Kruppel-like factor 9 inhibits the growth of ovarian cancer

Qing-hua Zhang et al.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2015)

Add to Collection

Article Hematology

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells

Duohui Jing et al.

BLOOD (2015)

Add to Collection

Article Biochemistry & Molecular Biology

MethHC: a database of DNA methylation and gene expression in human cancer

Wei-Yun Huang et al.

NUCLEIC ACIDS RESEARCH (2015)

Add to Collection

Article Biotechnology & Applied Microbiology

Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages

Yurii Chinenov et al.

BMC GENOMICS (2014)

Add to Collection

Article Oncology

Transcription factor KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression

Jiabin Sun et al.

CANCER LETTERS (2014)

Add to Collection

Article Endocrinology & Metabolism

Kruppel-Like Factor 9 Deficiency in Uterine Endometrial Cells Promotes Ectopic Lesion Establishment Associated With Activated Notch and Hedgehog Signaling in a Mouse Model of Endometriosis

Melissa E. Heard et al.

ENDOCRINOLOGY (2014)

Add to Collection

Article Oncology

The fate of Kruppel-like factor 9-positive hepatic carcinoma cells may be determined by the programmed cell death protein 5

Da-Zhi Fu et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Kruppel-like Factor-9 (KLF9) Inhibits Glioblastoma Stemness through Global Transcription Repression and Integrin α6 Inhibition

Mingyao Ying et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Add to Collection

Article Immunology

KLF13 Cooperates with c-Maf To Regulate IL-4 Expression in CD4+ T Cells

Seok Joo Kwon et al.

JOURNAL OF IMMUNOLOGY (2014)

Add to Collection

Article Biochemistry & Molecular Biology

CLOCK-Controlled Polyphonic Regulation of Circadian Rhythms through Canonical and Noncanonical E-Boxes

Hikari Yoshitane et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Nrf2 Amplifies Oxidative Stress via Induction of Klf9

Shoshanna N. Zucker et al.

MOLECULAR CELL (2014)

Add to Collection

Article Multidisciplinary Sciences

Thyroid Hormone Regulation of Gene Expression in Primary Cerebrocortical Cells: Role of Thyroid Hormone Receptor Subtypes and Interactions with Retinoic Acid and Glucocorticoids

Pilar Gil-Ibanez et al.

PLOS ONE (2014)

Add to Collection

Article Endocrinology & Metabolism

KLF9, a Transcription Factor Induced in Flutamide-Caused Cell Apoptosis, Inhibits AKT Activation and Suppresses Tumor Growth of Prostate Cancer Cells

Pengliang Shen et al.

PROSTATE (2014)

Add to Collection

Article Medical Laboratory Technology

The Evaluation of the FOXO1, KLF9 and YT521 Genes Expression in Human Endometrial Cancer

Mohsen Korani et al.

CLINICAL LABORATORY (2013)

Add to Collection

Article Multidisciplinary Sciences

A New Family of Predicted Kruppel-Like Factor Genes and Pseudogenes in Placental Mammals

Jimin Pei et al.

PLOS ONE (2013)

Add to Collection

Article Reproductive Biology

The Reproductive Phenotype of Mice Null for Transcription Factor Kruppel-Like Factor 13 Suggests Compensatory Function of Family Member Kruppel-Like Factor 9 in the Peri-Implantation Uterus

Melissa E. Heard et al.

BIOLOGY OF REPRODUCTION (2012)

Add to Collection

Article Hematology

KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells

Sudha Mannava et al.

BLOOD (2012)

Add to Collection

Article Endocrinology & Metabolism

Molecular Basis for Glucocorticoid Induction of the Kruppel-Like Factor 9 Gene in Hippocampal Neurons

Pia Bagamasbad et al.

ENDOCRINOLOGY (2012)

Add to Collection

Article Endocrinology & Metabolism

Kruppel-Like Factor 9 and Progesterone Receptor Coregulation of Decidualizing Endometrial Stromal Cells: Implications for the Pathogenesis of Endometriosis

John Mark P. Pabona et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Add to Collection

Article Neurosciences

The T3-induced gene KLF9 regulates oligodendrocyte differentiation and myelin regeneration

Jason C. Dugas et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2012)

Add to Collection

Article Genetics & Heredity

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations

Yukinori Okada et al.

NATURE GENETICS (2012)

Add to Collection

Article Multidisciplinary Sciences

Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes

Florian Spoerl et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection

Article Multidisciplinary Sciences

Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor α1 and kruppel-like factor 9 in Purkinje cells

Hasan X. Avci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection

Article Biochemistry & Molecular Biology

A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth

Martin E. Fernandez-Zapico et al.

BIOCHEMICAL JOURNAL (2011)

Add to Collection

Article Reproductive Biology

Kruppel-Like Factor 9 Loss-of-Expression in Human Endometrial Carcinoma Links Altered Expression of Growth-Regulatory Genes with Aberrant Proliferative Response to Estrogen

Christian D. Simmons et al.

BIOLOGY OF REPRODUCTION (2011)

Add to Collection

Article Biochemistry & Molecular Biology

Kruppel-like factor KLF9 regulates PPARγ transactivation at the middle stage of adipogenesis

H. Pei et al.

CELL DEATH AND DIFFERENTIATION (2011)

Add to Collection

Article Immunology

KLF13 sustains thymic memory-like CD8+ T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells

Dazhi Lai et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Add to Collection

Article Cell & Tissue Engineering

Kruppel-Like Family of Transcription Factor 9, a Differentiation-Associated Transcription Factor, Suppresses Notch1 Signaling and Inhibits Glioblastoma-Initiating Stem Cells

Mingyao Ying et al.

STEM CELLS (2011)

Add to Collection

Article Reproductive Biology

HOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium

Hongling Du et al.

BIOLOGY OF REPRODUCTION (2010)

Add to Collection

Article Cell Biology

Overexpression of KLF13 and FGFR3 in Oral Cancer Cells

B.J. Henson et al.

CYTOGENETIC AND GENOME RESEARCH (2010)

Add to Collection

Article Endocrinology & Metabolism

Functional Differentiation of Uterine Stromal Cells Involves Cross-Regulation between Bone Morphogenetic Protein 2 and Kruppel-Like Factor (KLF) Family Members KLF9 and KLF13

John Mark P. Pabona et al.

ENDOCRINOLOGY (2010)

Add to Collection

Article Endocrinology & Metabolism

Response of adult mouse uterus to early disruption of estrogen receptor-α signaling is influenced by Kruppel-like factor 9

C. D. Simmons et al.

JOURNAL OF ENDOCRINOLOGY (2010)

Add to Collection

Article Immunology

Increased B Cell Proliferation and Reduced Ig Production in DREAM Transgenic Mice

Magali Savignac et al.

JOURNAL OF IMMUNOLOGY (2010)

Add to Collection

Article Cell Biology

Bimodal, Reciprocal Regulation of Fibroblast Growth Factor Receptor 1 Promoter Activity by BTEB1/KLF9 during Myogenesis

Darrion L. Mitchell et al.

MOLECULAR BIOLOGY OF THE CELL (2010)

Add to Collection

Article Endocrinology & Metabolism

Stressor and Glucocorticoid-Dependent Induction of the Immediate Early Gene Kruppel-Like Factor 9: Implications for Neural Development and Plasticity

Ronald M. Bonett et al.

ENDOCRINOLOGY (2009)

Add to Collection

Article Biochemistry & Molecular Biology

Target Identification of microRNAs Expressed Highly in Human Embryonic Stem Cells

Steven Shoei-Lung Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2009)

Add to Collection

Article Neurosciences

Kruppel-Like Factor 9 Is Necessary for Late-Phase Neuronal Maturation in the Developing Dentate Gyrus and during Adult Hippocampal Neurogenesis

Kimberly N. Scobie et al.

JOURNAL OF NEUROSCIENCE (2009)

Add to Collection

Article Endocrinology & Metabolism

Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells

Sekar Natesampillai et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)

Add to Collection

Article Cell Biology

KLF13 influences multiple stages of both B and T cell development

Susan V. Outram et al.

CELL CYCLE (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Splenomegaly and modified erythropoiesis in KLF13-/- mice

Adele R. Gordon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Add to Collection

Article Pathology

Downregulation of Kruppel-like factor 9 in human colorectal cancer

Ling Kang et al.

PATHOLOGY INTERNATIONAL (2008)

Add to Collection

Article Endocrinology & Metabolism

The Kruppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression

Frank A. Simmen et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2008)

Add to Collection

Review Oncology

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

Markus Welcker et al.

NATURE REVIEWS CANCER (2008)

Add to Collection

Article Endocrinology & Metabolism

Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor α signaling in Ishikawa endometrial adenocarcinoma cells

Michael C. Velarde et al.

MOLECULAR ENDOCRINOLOGY (2007)

Add to Collection

Article Oncology

Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer

Ido Wolf et al.

BREAST CANCER RESEARCH AND TREATMENT (2007)

Add to Collection

Article Multidisciplinary Sciences

Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses

Kim L. Good et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Add to Collection

Article Gastroenterology & Hepatology

Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9

Frank A. Simmen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)

Add to Collection

Article Immunology

Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription

Boli Huang et al.

JOURNAL OF IMMUNOLOGY (2007)

Add to Collection

Article Immunology

Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo

Meixia Zhou et al.

JOURNAL OF IMMUNOLOGY (2007)

Add to Collection

Article Cell Biology

The KLF family of transcriptional regulators in cardiomyocyte proliferation and differentiation

Mona Nemer et al.

CELL CYCLE (2007)

Add to Collection

Article Biochemistry & Molecular Biology

Dynamic interplay of transcriptional machinery and chromatin regulates late expression of the chemokine RANTES in T lymphocytes

Yong-Tae Ahn et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Add to Collection

Review Urology & Nephrology

Mechanisms of disease: regulation of RANTES (CCL5) in renal disease

Alan M. Krensky et al.

NATURE CLINICAL PRACTICE NEPHROLOGY (2007)

Add to Collection

Article Biochemistry & Molecular Biology

The Kruppel-like transcription factor KLF13 is a novel regulator of heart development

Genevieve Lavallee et al.

EMBO JOURNAL (2006)

Add to Collection

Article Endocrinology & Metabolism

Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Kruppel-like factor 9/basic transcription element binding protein-1

MC Velarde et al.

ENDOCRINOLOGY (2006)

Add to Collection

Article Hematology

A functional screen for Kruppel-like factors that regulate the human γ-globin gene through the CACCC promoter element

P Zhang et al.

BLOOD CELLS MOLECULES AND DISEASES (2005)

Add to Collection

Article Reproductive Biology

Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice

MC Velarde et al.

BIOLOGY OF REPRODUCTION (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells

A Mitsuma et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene

RCM Simmen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Add to Collection

Article Biochemistry & Molecular Biology

Selective modulation of the SM22α promoter by the binding of BTEB3 (basal transcription element-binding protein 3) to TGGG repeats

KM Martin et al.

BIOCHEMICAL JOURNAL (2003)

Add to Collection

Article Biochemistry & Molecular Biology

An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation

ME Fernandez-Zapico et al.

EMBO JOURNAL (2003)

Add to Collection

Article Biochemistry & Molecular Biology

Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A

YP Pang et al.

FEBS LETTERS (2003)

Add to Collection

Article Biochemistry & Molecular Biology

Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity

CZ Song et al.

JOURNAL OF MOLECULAR BIOLOGY (2003)

Add to Collection

Article Biochemistry & Molecular Biology

Functional analysis of basic transcription element binding protein by gene targeting technology

M Morita et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Add to Collection

Article Biochemistry & Molecular Biology

Recruitment of a repressosome complex at the growth hormone receptor promoter and its potential role in diabetic nephropathy

PM Gowri et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Add to Collection

Review Biotechnology & Applied Microbiology

Sp1-and Kruppel-like transcription factors

J Kaczynski et al.

GENOME BIOLOGY (2003)

Add to Collection

Article Neurosciences

Identification of new thyroid hormone-regulated genes in rat brain neuronal cultures

J Martel et al.

NEUROREPORT (2002)

Add to Collection

Article Biochemistry & Molecular Biology

Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Kruppel-like transcription factor of activated T lymphocytes

A Song et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Add to Collection

Article Biochemistry & Molecular Biology

Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor

V Ellenrieder et al.

EMBO JOURNAL (2002)

Add to Collection

Article Biochemistry & Molecular Biology

Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Kruppel-like factor BTEB1

RCM Simmen et al.

DNA AND CELL BIOLOGY (2002)

Add to Collection

Article Biochemistry & Molecular Biology

The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1

J Kaczynski et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Add to Collection

Article Biochemistry & Molecular Biology

A conserved α-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A

JS Zhang et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Add to Collection

Article Cell Biology

Increased expression of the Zn-finger transcription factor BTEB1 in human endometrial cells is correlated with distinct cell phenotype, gene expression patterns, and proliferative responsiveness to serum and TGF-β1

XL Zhang et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2001)

Add to Collection

Article Developmental Biology

Expression of Klf9 and Klf13 in mouse development

KM Martin et al.

MECHANISMS OF DEVELOPMENT (2001)

Add to Collection

Article Biotechnology & Applied Microbiology

Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family

S Scohy et al.

GENOMICS (2000)

Add to Collection

Article Biochemistry & Molecular Biology

Up-regulation of gut-enriched kruppel-like factor by interferon-γ in human colon carcinoma cells

ZY Chen et al.

FEBS LETTERS (2000)

Add to Collection

Article Biochemistry & Molecular Biology

The DNA binding protein BTEB mediates acetaldehyde-induced, Jun N-terminal kinase-dependent αI(I) collagen gene expression in rat hepatic stellate cells

AP Chen et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.