☆ 4.7 Article

Genetic Correlation of miRNA Polymorphisms and STAT3 Signaling Pathway with Recurrent Implantation Failure in the Korean Population

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Related references

Note: Only part of the references are listed.

Review Genetics & Heredity

MicroRNAs, small regulatory elements with significant effects on human implantation: a review

Elham Azizi et al.

Summary: Embryo implantation is a critical process that requires synchronized interaction between the blastocyst and a receptive endometrium. MicroRNAs (miRNAs) play important roles in regulating genes involved in the implantation process and their dysregulation can lead to implantation disorders. MiRNAs can also be used as non-invasive diagnostic biomarkers in body fluids and blood for different pathological and physiological conditions. Recent studies have focused on the role of intracellular and extracellular miRNAs in human implantation and their influence on implantation disorders, highlighting their potential as biomarkers.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2023)

Add to Collection

Review Endocrinology & Metabolism

Recurrent implantation failure: A comprehensive summary from etiology to treatment

Junying Ma et al.

Summary: Recurrent implantation failure (RIF) is a common problem in couples undergoing in vitro fertilization and embryo transfer. The lack of widely accepted definitions and treatment protocols hampers the progress in predicting and preventing RIF. The possible causes of RIF include immunology, thrombophilias, endometrial receptivity, microbiome, anatomical abnormalities, male factors, and embryo aneuploidy. Individualized treatment aimed at addressing the primary cause is crucial in increasing the implantation rate.

FRONTIERS IN ENDOCRINOLOGY (2023)

Add to Collection

Article Immunology

Novel polymorphism of IFI44L associated with the susceptibility and clinical characteristics of systemic lupus erythematosus in a Chinese population

Qing Zhang et al.

Summary: This study aimed to evaluate the association between IFI44L rs273259 polymorphism and the susceptibility and clinical characteristics of Systemic lupus erythematosus (SLE) in a Chinese population. The results showed significant differences in the genotype and allele frequencies of IFI44L rs273259 between SLE patients and healthy controls. IFI44L rs273259 polymorphism was associated with clinical characteristics of SLE including malar rash, discoid rash, lupus nephritis, and anti-Smith antibodies.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

Add to Collection

Review Developmental Biology

Immunomodulation for unexplained recurrent implantation failure: where are we now?

Genevieve Genest et al.

Summary: Immune dysfunction can cause recurrent implantation failure. This article evaluates the immune responses during implantation and the effectiveness of immunomodulatory therapies. Recurrent implantation failure (RIF) is defined as the failure to achieve pregnancy after transferring at least 3 good-quality embryos, and its cause is unexplained in 50% of cases. Currently, there are no effective treatments for unexplained RIF. Modulating the maternal immune response during implantation is a recent strategy to improve conception rates in RIF patients, but there are no confirmed diagnostic tests for immune-mediated RIF.

REPRODUCTION (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Association of Polymorphisms in FSHR, INHA, ESR1, and BMP15 with Recurrent Implantation Failure

Eun-Ju Ko et al.

Summary: Recurrent implantation failure (RIF) refers to multiple unsuccessful in vitro fertilization embryo transfers in the same individual. Genetic factors, including SNPs in FSHR, INHA, ESR1, and BMP15, have been found to be associated with RIF development in Korean women.

BIOMEDICINES (2023)

Add to Collection

Article Biochemistry & Molecular Biology

LncRNA LINC01123 promotes malignancy of ovarian cancer by targeting hsa-miR-516b-5p/VEGFA

Bing Dong et al.

Summary: The study aimed to determine the role of lncRNA LINC01123 in ovarian cancer (OC) bio-progression. It was found that LINC01123 was upregulated in OC cell lines and its silencing suppressed cell proliferation and metastasis while promoting apoptosis. Additionally, hsa-miR-516b-5p was linked to LINC01123 and VEGFA was downstream of hsa-miR-516b-5p. These findings suggest that LINC01123 promotes OC development by dampening miR-516b-5p function.

GENES & GENOMICS (2023)

Add to Collection

Article Genetics & Heredity

Genetic Association between Inflammatory-Related Polymorphism in STAT3, IL-1 beta, IL-6, TNF-a and Idiopathic Recurrent Implantation Failure

Min Jung Kwon et al.

Summary: Recurrent implantation failure (RIF) refers to the inability to achieve pregnancy after multiple embryo transfers. In this Korean study, the association between certain genetic variations (STAT3 rs1053004, IL-1 beta rs16944, IL-6 rs1800796, and TNF-alpha rs1800629, 1800630) and RIF prevalence was analyzed. The results showed a significant association between STAT3 rs1053004, IL-6 rs1800796, TNF-alpha rs1800629, and RIF prevalence, providing new insights into the role of inflammation in RIF.

GENES (2023)

Add to Collection

Article Genetics & Heredity

Association Study between Mucin 4 (MUC4) Polymorphisms and Idiopathic Recurrent Pregnancy Loss in a Korean Population

Ji-Hyang Kim et al.

Summary: The study found an association between MUC4 gene polymorphisms and RPL, particularly the rs882605 C>A and rs1104760 A>G polymorphisms. These findings suggest that MUC4 polymorphisms may serve as potential biomarkers for RPL.

GENES (2022)

Add to Collection

Review Immunology

The Inflammatory Cytokine Imbalance for Miscarriage, Pregnancy Loss and COVID-19 Pneumonia

Fortunato Vesce et al.

Summary: Pregnancy is a vascular event controlled by endocrine factors. During pregnancy, the chorionic villi penetrate the uterine spiral arteries to provide nutrients and oxygen for fetal growth. Vascular function is regulated by prostaglandins and thromboxane for vasoconstriction, and prostacyclin for vasodilation. The fetus can alter the maternal immune response to protect itself. Inflammation is a leading cause of pregnancy-related complications. In both COVID-19 pneumonia and gestational inflammation, preventing and counteracting inflammation is crucial.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

miRNA: A Promising Therapeutic Target in Cancer

Amrutha Menon et al.

Summary: This review focuses on the role of miRNA in cancer, therapeutic approaches with miRNAs, and effective delivery into the system. Patents and ongoing clinical trials for miRNA therapy are also summarized.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Medicine, Research & Experimental

miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia

Jasenka Guduric-Fuchs et al.

Summary: miR-130a acts as a mediator in the hypoxic response of ECFCs, enhancing their angiogenic and vasoreparative abilities by coordinating the upregulation of VEGFR2/STAT3/HIF1 alpha axis through translational inhibition of Ddx6.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Add to Collection

Article Oncology

Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion

Xun Wu et al.

Summary: miR-34a directly targets MET and acts as a tumor suppressor in HNSCC by inhibiting HNSCC cell proliferation. Administration of LNA-miR-34a reduces HNSCC cell proliferation and tumor burden, suppresses immunosuppressive effects in the tumor microenvironment, and increases the frequency of Th1 cells and CD8 naive T cells in HNSCC patient samples.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Medicine, General & Internal

Mechanism of miR-218-5p in autophagy, apoptosis and oxidative stress in rheumatoid arthritis synovial fibroblasts is mediated by KLF9 and JAK/STAT3 pathways

Ming Chen et al.

Summary: The study reveals that miR-218-5p regulates proliferation, apoptosis, autophagy, and oxidative stress in rheumatoid arthritis synovial fibroblasts by targeting KLF9 and the JAK2/STAT3 signaling pathway. Knockdown of miR-218-5p may provide a potential therapeutic target for understanding the mechanism of RA.

JOURNAL OF INVESTIGATIVE MEDICINE (2021)

Add to Collection

Article Multidisciplinary Sciences

Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment

Takehiro Hiraoka et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The association of AGO1 (rs595961G>A, rs636832A>G) and AGO2 (rs11996715C>A, rs2292779C>G, rs4961280C>A) polymorphisms and risk of recurrent implantation failure

Chang Soo Ryu et al.

BIOSCIENCE REPORTS (2019)

Add to Collection

Article Genetics & Heredity

Identification of microRNA biomarkers in the blood of breast cancer patients based on microRNA profiling

Kai Zhang et al.

GENE (2017)

Add to Collection

Review Biochemistry & Molecular Biology

STAT3 signaling in immunity

Emily J. Hillmer et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2016)

Add to Collection

Article Obstetrics & Gynecology

MicroRNA and implantation

Daniela Galliano et al.

FERTILITY AND STERILITY (2014)

Add to Collection

Article Medicine, Research & Experimental

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

Matjaz Rokavec et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Add to Collection

Review Obstetrics & Gynecology

Recurrent implantation failure: definition and management

C. Coughlan et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2014)

Add to Collection

Article Endocrinology & Metabolism

Spontaneous Abortion, Stillbirth and Hyperthyroidism: A Danish Population-Based Study

Stine Linding Andersen et al.

EUROPEAN THYROID JOURNAL (2014)

Add to Collection

Article Biotechnology & Applied Microbiology

The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges

Andrew P. Hutchins et al.

BRIEFINGS IN FUNCTIONAL GENOMICS (2013)

Add to Collection

Article Endocrinology & Metabolism

STAT3 Regulates Uterine Epithelial Remodeling and Epithelial-Stromal Crosstalk During Implantation

Sandeep Pawar et al.

MOLECULAR ENDOCRINOLOGY (2013)

Add to Collection

Article Endocrinology & Metabolism

Cell-Type-Specific Expression of STAT Transcription Factors in Tissue Samples from Patients with Lymphocytic Thyroiditis

Julia Staab et al.

ENDOCRINE PATHOLOGY (2012)

Add to Collection

Article Multidisciplinary Sciences

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

Sergej Djuranovic et al.

SCIENCE (2012)

Add to Collection

Article Multidisciplinary Sciences

Inflammation and pregnancy: the role of the immune system at the implantation site

Gil Mor et al.

REPRODUCTIVE SCIENCE (2011)

Add to Collection

Review Immunology

Inflammation and Implantation

Nava Dekel et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2010)

Add to Collection

Article Obstetrics & Gynecology

Inflammation in Reproductive Disorders

Gerson Weiss et al.

REPRODUCTIVE SCIENCES (2009)

Add to Collection

Review Endocrinology & Metabolism

The role of the placenta in thyroid hormone delivery to the fetus

Shiao Y. Chan et al.

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM (2009)

Add to Collection

© Peeref 2019-2024. All rights reserved.