The Role of CPNE7 (Copine-7) in Colorectal Cancer Prognosis and Metastasis

Article Biochemistry & Molecular Biology

Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment?

Leonard A. A. Lobbes et al.

Summary: The study found that high expression of M3R in colorectal cancer patients is associated with increased survival, and is also correlated with the expression of other immune cell markers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Pharmacology & Pharmacy

Constructing a cancer stem cell related prognostic model for predicting immune landscape and drug sensitivity in colorectal cancer

Jianfang Chen et al.

Summary: This study identified 29 CSC marker genes associated with CRC and developed a prognostic model to predict the response and prognosis of CRC patients.

FRONTIERS IN PHARMACOLOGY (2023)

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Article Biochemistry & Molecular Biology

Expression of Spermine Oxidase Is Associated with Colorectal Carcinogenesis and Prognosis of Patients

Sooyoun Kim et al.

Summary: This study revealed that SMOX is overexpressed in colorectal cancer and may serve as an important oncogene in CRC. Moreover, SMOX overexpression could be a valuable prognostic marker and potential therapeutic target for CRC.

BIOMEDICINES (2022)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Cell Biology

Upregulation of CPNE7 in mesenchymal stromal cells promotes oral squamous cell carcinoma metastasis through the NF-κB pathway

Xiaoli Ji et al.

Summary: In this study, it was found that MSCs derived from OSCC promoted OSCC cell metastasis by secreting CXCL8 and upregulating CPNE7 to activate the NF-kappa B pathway. The activation mechanism of CPNE7 includes phosphorylated p65 and I kappa Ba, with silencing of CPNE7 inhibiting metastasis and overexpression promoting this process.

CELL DEATH DISCOVERY (2021)

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Review Genetics & Heredity

The CPNE Family and Their Role in Cancers

Haicheng Tang et al.

Summary: Lung cancer is the leading cause of cancer-related deaths worldwide, and CPNE family members play important roles in cancer development and progression, although their expression patterns and clinical roles in cancer have not yet been well understood.

FRONTIERS IN GENETICS (2021)

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Review Oncology