Journal
JOURNAL OF CELL BIOLOGY
Volume 223, Issue 1, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.202307150
Keywords
-
Categories
Ask authors/readers for more resources
This review summarizes the current knowledge of multiciliogenesis and highlights recent advances in understanding the regulation of multiple motile cilia formation.
Lyu et al. summarize the current knowledge of multiciliogenesis by which the respiratory tract, brain ventricles, and reproductive tracts of vertebrates form multiple motile cilia for tissue homeostasis. In vertebrates, multiciliated cells (MCCs) are terminally differentiated cells that line the airway tracts, brain ventricles, and reproductive ducts. Each MCC contains dozens to hundreds of motile cilia that beat in a synchronized manner to drive fluid flow across epithelia, the dysfunction of which is associated with a group of human diseases referred to as motile ciliopathies, such as primary cilia dyskinesia. Given the dynamic and complex process of multiciliogenesis, the biological events essential for forming multiple motile cilia are comparatively unelucidated. Thanks to advancements in genetic tools, omics technologies, and structural biology, significant progress has been achieved in the past decade in understanding the molecular mechanism underlying the regulation of multiple motile cilia formation. In this review, we discuss recent studies with ex vivo culture MCC and animal models, summarize current knowledge of multiciliogenesis, and particularly highlight recent advances and their implications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available