Functional defects in cementoblasts with disrupted bone sialoprotein functional domains, in vitro

Article Dentistry, Oral Surgery & Medicine

Bone Sialoprotein Is Critical for Alveolar Bone Healing in Mice

M. B. Chavez et al.

Summary: Bone sialoprotein (BSP) is a critical factor for alveolar bone healing, and its absence disrupts multiple major pathways involved in appropriate healing.

JOURNAL OF DENTAL RESEARCH (2023)

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Article Dentistry, Oral Surgery & Medicine

Loss of β-catenin causes cementum hypoplasia by hampering cementogenic differentiation of Axin2-expressing cells

Rui Ma et al.

Summary: This study aimed to evaluate the effects of beta-catenin deletion in Axin2(+) cells on cementogenesis. The results showed that loss of beta-catenin in Axin2(+) cells led to a sharp reduction in cementum formation and inhibited the differentiation of Axin2(+) cells into cementoblasts positive for osteopontin.

JOURNAL OF PERIODONTAL RESEARCH (2023)

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Review Cell Biology

The role of integrin family in bone metabolism and tumor bone metastasis

Liwei Mao et al.

Summary: Integrins play a crucial role in cell-extracellular matrix adhesion and cytokine receptor signal transduction, regulating bone metabolism. Recent studies have uncovered the involvement of integrins in bone metabolism pathways and their interaction with novel cytokines. Integrins act as transducers, mediating the effects of mechanical stress, fluid shear stress, microgravity, hypergravity, and other physical factors on bone-related cells. They also play a role in mediating bone metastasis of various cancers. Targeted therapy involving integrins shows promising potential for bone metabolic diseases. This review provides insights into the latest research on integrins in bone metabolism and metastasis and offers a vision for treatment strategies.

CELL DEATH DISCOVERY (2023)

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Article Anatomy & Morphology

Knockout of bone sialoprotein in cementoblasts cell lines affects specific gene expression in unstimulated and mechanically stimulated conditions

Charlotte E. Roth et al.

Summary: This study investigates the influence of bone sialoprotein (BSP) on cementoblasts and its role in regulating the organization of cementum. The findings suggest that BSP markers in cementoblasts play an important role in the regulation of periodontal tissues and cellular cementum remodeling. This provides a basis for further investigations into the molecular biology interactions of BSP in cementoblasts and understanding of periodontal diseases and cementum remodeling.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2023)

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Article Dentistry, Oral Surgery & Medicine

The RGD region of bone sialoprotein affects metabolic activity in mice

Karin Nagasaki et al.

Summary: This study reveals that the RGD region of bone sialoprotein (BSP) affects energy metabolism by regulating food intake, with further studies needed to uncover the underlying mechanisms.

FRONTIERS IN DENTAL MEDICINE (2023)

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Article Dentistry, Oral Surgery & Medicine

The Bone Sialoprotein RGD Domain Modulates and Maintains Periodontal Development

K. Nagasaki et al.

Summary: Bone sialoprotein plays an important role in periodontal development and mineralization, particularly through its RGD domain.

JOURNAL OF DENTAL RESEARCH (2022)

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Article Dentistry, Oral Surgery & Medicine

Delivery of Alkaline Phosphatase Promotes Periodontal Regeneration in Mice

A. Nagasaki et al.

Summary: This study demonstrated that pharmacologic modulation of Pi/PPi metabolism can overcome periodontal breakdown and achieve regeneration through both in vivo and in vitro approaches.

JOURNAL OF DENTAL RESEARCH (2021)

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Article Endocrinology & Metabolism