Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 576, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2023.111655
Keywords
S-systems; Biochemical systems theory; Design principles; Systems biology; Systems design space analysis; Mathematically controlled comparisons; Robustness; Canonical nonlinear forms
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Michael Savageau's Biochemical Systems Analysis papers have had a significant impact on Systems Biology, generating core concepts and tools. This article provides a brief summary of these papers and discusses the most relevant developments in Biochemical Systems Theory since their publication.
Michael Savageau's Biochemical Systems Analysis I, II, III papers, published in volumes 25 and 26 of the journal, kickstarted a research programme that originated many of the core concepts and tools of Systems Biology. This article briefly summarizes these papers and discusses the most relevant developments in Biochemical Systems Theory since their publication.
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