Journal
COORDINATION CHEMISTRY REVIEWS
Volume 500, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2023.215429
Keywords
Gold(I); Gold(III); Auranofin; Drug repurposing; Metal-based drugs; Antibacterial
Categories
Ask authors/readers for more resources
This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
Bacterial infections pose a significant threat to public health and the global economy. The misuse of antibiotics in the treatment of bacterial infections has led to a rapid development of antibiotic-resistant bacteria which demands the development of new antibiotics for effective therapy. Gold complexes manifest prominent antibacterial activities against a broad panel of bacterial strains, indicating their great potential for development as potent antibiotics. The present review article provides an overview of the antibacterial activity of gold complexes since the year 2000, with an emphasis on the past decade, and with separate sections dedicated to the discussion of gold(I) and gold(III) complexes. Further, a summary is provided on the repurposing of Auranofin for antibacterial purposes, along with a summary of the reported associated mechanism(s) of action. This overview is provided to offer insight into the rational design of gold complexes with bio-efficacy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available