☆ 4.7 Article

Distinct HAND2/HAND2-AS1 Expression Levels May Fine-Tune Mesenchymal and Epithelial Cell Plasticity of Human Mesenchymal Stem Cells

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Related references

Note: Only part of the references are listed.

Letter Gastroenterology & Hepatology

Long non-coding RNA HAND2-AS1: A potential therapeutic target in the treatment of gastric cancer?

Min-Jie Chen et al.

DIGESTIVE AND LIVER DISEASE (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates foam cell formation in atherosclerosis

Lingyun Ma et al.

Summary: Abnormally expressed long non-coding RNAs (lncRNAs) play important roles in cardiovascular disease, but their role in atherosclerosis (AS) is still unclear. This study focused on HAND2 Antisense RNA 1 (HAND2-AS1) and found that it could alleviate foam cell formation within AS by targeting the miR-128/SIRT1 axis, suggesting it may be a potential therapeutic target for AS.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2022)

Add to Collection

Retraction Biotechnology & Applied Microbiology

撤稿声明: lncRNA HAND2-AS1 Regulates Prostate Cancer Cell Growth Through Targeting the miR-106a-5p/RBM24 Axis (Retraction of Vol 13, Pg 4523, 2020)

P. Wei et al.

ONCOTARGETS AND THERAPY (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

The adult heart requires baseline expression of the transcription factor Hand2 to withstand right ventricular pressure overload

Raquel F. Videira et al.

Summary: Research on the pathophysiology of right ventricular (RV) failure has lagged behind compared to the left ventricle (LV), despite high mortality and morbidity. Previous studies showed that Hand2 reactivation in adult hearts contributes to pathological remodeling, but hand2 depletion led to severe cardiac dysfunction in response to RV pressure overload. This study emphasized the importance of understanding molecular mechanisms driving pathological remodeling of RV.

CARDIOVASCULAR RESEARCH (2022)

Add to Collection

Article Clinical Neurology

LncRNA HAND2-AS1 attenuates glioma cell proliferation, invasion and migration by targeting CDK6

Songlin Liu et al.

Summary: This study revealed that the lncRNA HAND2-AS1 is downregulated in glioma tissues and cell lines, and its overexpression can inhibit the proliferation, invasion, and migration of glioma cells. Furthermore, HAND2-AS1 exerts its anti-tumorigenic role in glioma by negatively regulating CDK6 expression.

NEUROLOGICAL RESEARCH (2022)

Add to Collection

Article Multidisciplinary Sciences

Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma

Karin D. Prummel et al.

Summary: This study uncovers the early origins of mesothelium progenitor cells in zebrafish, linking the function of the Hand2 gene to mesothelium formation and the re-activation of mesothelioma tumors.

NATURE COMMUNICATIONS (2022)

Add to Collection

Review Cell & Tissue Engineering

Synthetic developmental biology: Engineering approaches to guide multicellular organization

Ibrahim Zarkesh et al.

Summary: Synthetic developmental biology is a multidisciplinary concept that utilizes engineering approaches to guide the self-organization of multicellular tissues. Organoids are 3D structures developed in vitro that display important aspects of their in vivo counterparts and are generated through a self-organization process from pluripotent or tissue-specific stem cells. This review introduces a novel classification of engineering approaches based on the extent of microenvironmental manipulation applied to organoids. The authors also discuss how engineering tools can help overcome current limitations in organoid construction.

STEM CELL REPORTS (2022)

Add to Collection

Article Cell Biology

Epigenetic silencing and tumor suppressor gene of HAND2 by targeting ERK signaling in colorectal cancer

Zixu Yuan et al.

Summary: This study identified HAND2 as a potential epigenetic driver gene in colorectal cancer (CRC). The researchers found a high frequency of HAND2 methylation in CRC patients, and this methylation was negatively correlated with gene silencing and poor survival. Demethylation treatment was able to restore HAND2 expression in CRC cells. Functional experiments showed that HAND2 reconstitution could inhibit cell proliferation, invasion, and migration in vitro. In a tumor xenograft model, HAND2 reconstruction significantly suppressed tumor growth. Furthermore, HAND2 was found to target the ERK signaling pathway and reduce ERK phosphorylation. Overall, this study suggests that HAND2 is a tumor suppressor gene that acts by targeting the ERK signaling pathway and has potential as an epigenetic driver gene in CRC.

CELL COMMUNICATION AND SIGNALING (2022)

Add to Collection

Letter Cardiac & Cardiovascular Systems

HAND2-AS1: A novel therapeutic target for atherosclerosis

Guang-Gui Zeng et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

SIRT1 upregulation promotes epithelial-mesenchymal transition by inducing senescence escape in endometriosis

Minghua Wang et al.

Summary: This study found that the quantity of endometrial epithelial cells and stromal fibroblasts in endometriosis is correlated with the expression level of SIRT1. Overexpression of SIRT1 in endometrial epithelial cells triggers the EMT process, allowing them to escape senescence induced by damage or oncogenes. This observation supports the hypothesis that genetic and epigenetic factors help endometrial epithelial cells evade senescence and promote the EMT process in endometriosis.

SCIENTIFIC REPORTS (2022)

Add to Collection

Article Cell & Tissue Engineering

Designing Biomaterials to Modulate Notch Signaling in Tissue Engineering and Regenerative Medicine

Kathleen Zohorsky et al.

Summary: The design of cell-instructive biomaterials is advancing, with a growing interest in bottom-up tissue engineering strategies. Notch signaling pathway plays a crucial role in tissue morphogenesis and repair, but there are limited studies on incorporating this pathway into biomaterial-based systems. Discussions on this topic provide valuable insights for tissue engineering and regenerative medicine research.

TISSUE ENGINEERING PART B-REVIEWS (2021)

Add to Collection

Article Medical Laboratory Technology

lncRNA HAND2-AS1 overexpression inhibits cancer cell proliferation in hepatocellular carcinoma by downregulating RUNX2 expression

Gui-Ying Jing et al.

Summary: HAND2-AS1 acts as a tumor suppressor in hepatocellular carcinoma by downregulating RUNX2 expression, leading to inhibition of cancer cell proliferation. In the patient groups, the plasma levels of HAND2-AS1 and RUNX2 were inversely correlated, but no significant correlation was found in the control group.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

Add to Collection

Article Orthopedics

Mesenchymal stem cell-originated exosomal lncRNA HAND2-AS1 impairs rheumatoid arthritis fibroblast-like synoviocyte activation through miR-143-3p/TNFAIP3/NF-κB pathway

Yuhua Su et al.

Summary: The study discovered that in rheumatoid arthritis, HAND2-AS1 expression is regulated by miR-143-3p and TNFAIP3, and may play a suppressive role in RA progression through exosome-mediated intercellular transfer of long non-coding RNA.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

Add to Collection

Review Medicine, Research & Experimental

HAND2-AS1: A functional cancer-related long non-coding RNA

Xinyu Gu et al.

Summary: HAND2-AS1 expression is generally lower in tumor tissues compared to adjacent normal tissues in various types of cancer, but it is upregulated in hepatocellular carcinoma where it promotes tumor development. Aberrant expression of HAND2-AS1 is closely linked to tumor progression and prognosis, and it plays a role in tumor cell biological processes.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Review Oncology

Towards decoding the coupled decision-making of metabolism and epithelial-to-mesenchymal transition in cancer

Dongya Jia et al.

Summary: Cancer cells exhibit plasticity in adjusting their metabolic phenotypes for survival and metastasis, with the developmental programme of epithelial-to-mesenchymal transition (EMT) playing a crucial role. The correlation between metabolic changes and EMT, as well as the extensive crosstalk between them, remains poorly understood, compromising the effectiveness of metabolic therapies targeting metastasis.

BRITISH JOURNAL OF CANCER (2021)

Add to Collection

Article Cell & Tissue Engineering

Novel synthetic biology approaches for developmental systems

Christine Ho et al.

Summary: This article discusses three areas where synthetic biology tools are used in studying and constructing developmental systems, including improving stem cell models, studying embryonic patterning, and using genetic circuits for patterning and morphogenesis in non-developmental systems. These tools and approaches specifically benefit the field of embryo models.

STEM CELL REPORTS (2021)

Add to Collection

Article Oncology

LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146

Liping Shan et al.

Summary: This study demonstrates that the long noncoding RNA HAND2-AS1 acts as a tumor suppressor in bladder cancer by releasing RARB from miR-146, leading to inhibition of tumor proliferation and invasion. This finding expands the understanding of HAND2-AS1-mediated regulatory networks and provides new insights to enhance RARB-targeted therapies for bladder cancer.

CANCER CELL INTERNATIONAL (2021)

Add to Collection

Review Cell Biology

Cellular dynamics of EMT: lessons from live in vivo imaging of embryonic development

Jeffrey D. Amack

Summary: Epithelial-mesenchymal transition (EMT) is a process where cells lose polarity and gain invasive properties, used in both embryonic development and wound healing in adults, as well as exploited by cancer cells. Regulation of EMT involves rapid changes in protein expression in response to cell signaling and environmental cues. Live imaging in model organisms allows for insights into EMT mechanisms, highlighting the importance of cytoskeletal dynamics in this process.

CELL COMMUNICATION AND SIGNALING (2021)

Add to Collection

Article Endocrinology & Metabolism

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling

Maude Giroud et al.

Summary: The study identifies HAND2 as a novel obesity-linked adipocyte transcription factor, highlighting new mechanisms of GR-dependent adipogenesis in humans and mice.

DIABETOLOGIA (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Mechanisms of Binding Specificity among bHLH Transcription Factors

Xabier de Martin et al.

Summary: The transcriptome of every cell is controlled by a complex network of interactions between transcription factors and their binding sites on DNA. Disruption of this network can lead to organism malfunction or serve as a substrate for positive natural selection. Understanding the specific determinants of TF-DNA interactions is challenging, as it involves integrating multiple mechanisms such as DNA motif preferences, post-translational modifications, and epigenetic modifications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Oncology

Long non-coding RNA HAND2-AS1/miR-106a/PTEN axis re-sensitizes cisplatin-resistant ovarian cells to cisplatin treatment

Lijun Li et al.

Summary: This study identified a lncRNA HAND2-AS1/miR-106a/PTEN axis that can sensitize DDP-resistant SKOV3/DDP cells to DDP treatment. Through the axis, HAND2-AS1 overexpression inhibited cell viability and promoted cell apoptosis in DDP-resistant cells, while miR-106a overexpression reversed these effects by downregulating PTEN and upregulating PI3K/AKT signaling.

MOLECULAR MEDICINE REPORTS (2021)

Add to Collection

Review Cell Biology

Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis

Guya D. Marconi et al.

Summary: The epithelial-mesenchymal transition (EMT) is a crucial event in cell development, playing key roles in wound healing and organ fibrosis. EMT is classified into three types: type-1 EMT, type-2 EMT, and type-3 EMT, each with specific functions in embryogenesis, wound healing, and cancer progression respectively.

CELLS (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis

Yan Gao et al.

Summary: The study revealed the crucial regulatory role of HAND2-AS1 in cervical cancer, which upregulated TIMP3 expression through competitive binding to miR-21-5p, leading to suppression of cell proliferation, migration, invasion, and promotion of apoptosis. HAND2-AS1 may serve as a potential target for cervical cancer therapy.

CANCER GENE THERAPY (2021)

Add to Collection

Article Cell Biology

Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway

Mahmoud Al-Azab et al.

AGING-US (2020)

Add to Collection

Article Oncology

lncRNA HAND2-AS1 Inhibits Liver Cancer Cell Proliferation and Migration by Upregulating SOCS5 to Inactivate the JAK-STAT Pathway

Daojie Yan et al.

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2020)

Add to Collection

Article Cell Biology

LncRNA HAND2-AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74

Junling Gong et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Oncology

Identification of key lncRNAs in the tumorigenesis of intraductal pancreatic mucinous neoplasm by coexpression network analysis

Jun Ding et al.

CANCER MEDICINE (2020)

Add to Collection

Review Cell Biology

Guidelines and definitions for research on epithelial-mesenchymal transition

Jing Yang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Long Non-Coding RNA HAND2-AS1 Acts as a Tumor Suppressor in High-Grade Serous Ovarian Carcinoma

Priyanka Gokulnath et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Endocrinology & Metabolism

90 YEARS OF PROGESTERONE New insights into progesterone receptor signaling in the endometrium required for embryo implantation

Francesco J. DeMayo et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2020)

Add to Collection

Article Medical Laboratory Technology

Role of HAND2-AS1 in human tumors

Chao-ming Da et al.

CLINICA CHIMICA ACTA (2020)

Add to Collection

Article Cell Biology

LncRNA HAND2-AS1 suppressed the growth of triple negative breast cancer via reducing secretion of MSCs derived exosomal miR-106a-5p

Li Xing et al.

Aging-US (2020)

Add to Collection

Review Endocrinology & Metabolism

Embryonic Development and Adult Regeneration of the Adrenal Gland

Ji-Hoon Kim et al.

ENDOCRINOLOGY AND METABOLISM (2020)

Add to Collection

Article Nanoscience & Nanotechnology

Robust Fabrication of Composite 3D Scaffolds with Tissue-Specific Bioactivity: A Proof-of-Concept Study

Muthu Kumar Krishnamoorthi et al.

ACS APPLIED BIO MATERIALS (2020)

Add to Collection

Article Genetics & Heredity

HAND2 loss-of-function mutation causes familial dilated cardiomyopathy

Hua Liu et al.

EUROPEAN JOURNAL OF MEDICAL GENETICS (2019)

Add to Collection

Article Obstetrics & Gynecology

Interleukin-15 and Interleukin-7 are the Major Cytokines to Maintain Endometriosis

Patrick Bellelis et al.

GYNECOLOGIC AND OBSTETRIC INVESTIGATION (2019)

Add to Collection

Review Biochemistry & Molecular Biology

New Insights into the Role of Epithelial-Mesenchymal Transition during Aging

Francisco Santos et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Cell Biology

Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90+subset

Helene Martini et al.

AGING CELL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling

Yanying Wang et al.

EMBO JOURNAL (2019)

Add to Collection

Review Cell Biology

Mesenchymal-epithelial transition in development and reprogramming

Duanqing Pei et al.

NATURE CELL BIOLOGY (2019)

Add to Collection

Review Cardiac & Cardiovascular Systems

Epithelial Properties of the Second Heart Field

Claudio Cortes et al.

CIRCULATION RESEARCH (2018)

Add to Collection

Review Developmental Biology

Neural crest delamination and migration: Looking forward to the next 150 years

Nadege Gouignard et al.

GENESIS (2018)

Add to Collection

Editorial Material Biology

Developmental engineering: design of clinically efficacious bioartificial tissues through developmental and systems biology

Petros Lenas et al.

SCIENCE CHINA-LIFE SCIENCES (2018)

Add to Collection

Article Multidisciplinary Sciences

Biological and mechanical interplay at the Macro- and Microscales Modulates the Cell-Niche Fate

Udi Sarig et al.

SCIENTIFIC REPORTS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Zefang Tang et al.

NUCLEIC ACIDS RESEARCH (2017)

Add to Collection

Article Multidisciplinary Sciences

Organoid-based epithelial to mesenchymal transition (OEMT) model: from an intestinal fibrosis perspective

Soojung Hahn et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Materials Science, Biomaterials

Restoring the biophysical properties of decellularized patches through recellularization

Gigi Chi Ting Au-Yeung et al.

BIOMATERIALS SCIENCE (2017)

Add to Collection

Article Biology

Addressing the ethical issues raised by synthetic human entities with embryo-like features

John Aach et al.

ELIFE (2017)

Add to Collection

Article Engineering, Biomedical

Biohybrid cardiac ECM-based hydrogels improve long term cardiac function post myocardial infarction

Yael Efraim et al.

ACTA BIOMATERIALIA (2017)

Add to Collection

Review Engineering, Biomedical

Extracellular matrix hydrogels from decellularized tissues: Structure and function

Lindsey T. Saldin et al.

ACTA BIOMATERIALIA (2017)

Add to Collection

Article Engineering, Biomedical

Natural myocardial ECM patch drives cardiac progenitor based restoration even after scarring

Udi Sarig et al.

ACTA BIOMATERIALIA (2016)

Add to Collection

Article Cardiac & Cardiovascular Systems

Epicardial infarct repair with bioinductive extracellular matrix promotes vasculogenesis and myocardial recovery

Holly E. M. Mewhort et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2016)

Add to Collection

Review Cell Biology

Organoids as an in vitro model of human development and disease

Aliya Fatehullah et al.

NATURE CELL BIOLOGY (2016)

Add to Collection

Article Developmental Biology

IL15 promotes growth and invasion of endometrial stromal cells and inhibits killing activity of NK cells in endometriosis

Jia-Jun Yu et al.

REPRODUCTION (2016)

Add to Collection

Article Multidisciplinary Sciences

Genome-wide identification of zero nucleotide recursive splicing in Drosophila

Michael O. Duff et al.

NATURE (2015)

Add to Collection

Article Cell & Tissue Engineering

Pushing the Envelope in Tissue Engineering: Ex Vivo Production of Thick Vascularized Cardiac Extracellular Matrix Constructs

Udi Sarig et al.

TISSUE ENGINEERING PART A (2015)

Add to Collection

Article Medical Laboratory Technology

A prospective epigenetic paradigm between cellular senescence and epithelial-mesenchymal transition in organismal development and aging

Shuji Kishi et al.

TRANSLATIONAL RESEARCH (2015)

Add to Collection

Article Biotechnology & Applied Microbiology

Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development

Linda Szabo et al.

GENOME BIOLOGY (2015)

Add to Collection

Article Cell Biology

Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium

Nathan J. VanDusen et al.

CELL REPORTS (2014)

Add to Collection

Review Obstetrics & Gynecology

The Mesenchymal-Epithelial Transition During In Vitro Decidualization

Xiu-Hong Zhang et al.

REPRODUCTIVE SCIENCES (2013)

Add to Collection

Review Multidisciplinary Sciences

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

M. Angela Nieto

SCIENCE (2013)

Add to Collection

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Add to Collection

Article Cell & Tissue Engineering

Thick Acellular Heart Extracellular Matrix with Inherent Vasculature: A Potential Platform for Myocardial Tissue Regeneration

Udi Sarig et al.

TISSUE ENGINEERING PART A (2012)

Add to Collection

Article Cardiac & Cardiovascular Systems

Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development

Ralston M. Barnes et al.

CIRCULATION RESEARCH (2011)

Add to Collection

Article Cell & Tissue Engineering

Acellular Cardiac Extracellular Matrix as a Scaffold for Tissue Engineering: In Vitro Cell Support, Remodeling, and Biocompatibility

Yuval Eitan et al.

TISSUE ENGINEERING PART C-METHODS (2010)

Add to Collection

Review Biochemistry & Molecular Biology

Epithelial-Mesenchymal Transitions in Development and Disease

Jean Paul Thiery et al.

CELL (2009)

Add to Collection

Review Cell & Tissue Engineering

Developmental Engineering: A New Paradigm for the Design and Manufacturing of Cell-Based Products. Part II. From Genes to Networks: Tissue Engineering from the Viewpoint of Systems Biology and Network Science

Petros Lenas et al.

TISSUE ENGINEERING PART B-REVIEWS (2009)

Add to Collection

Article Cell & Tissue Engineering

Developmental Engineering: A New Paradigm for the Design and Manufacturing of Cell-Based Products. Part I: From Three-Dimensional Cell Growth to Biomimetics of In Vivo Development

Petros Lenas et al.

TISSUE ENGINEERING PART B-REVIEWS (2009)

Add to Collection

Article Cell Biology

The formation of epithelial tubes

SeYeon Chung et al.

JOURNAL OF CELL SCIENCE (2008)

Add to Collection

Article Engineering, Biomedical

The extracellular matrix as a biologic scaffold material

Stephen F. Badylak

BIOMATERIALS (2007)

Add to Collection

Article Biochemistry & Molecular Biology

The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function

BA Firulli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.