Selenium Dioxide-Promoted Regioselective Synthesis of Multi-Substituted Furans from Terminal Alkynes and Aldehydes

A SeO2-mediated regioselective synthesis of multi-substituted furans has been achieved through intermolecular cyclization of terminal alkynes with aldehydes. The developed methodology used commercially available starting materials and afforded various 2,3,5-triarylfurans. +image

Automated summary

A regioselective synthesis of multi-substituted furans has been achieved using SeO2-mediated intermolecular cyclization. The developed methodology utilized commercially available starting materials and provided various 2,3,5-triarylfurans.