Relative inhibitory activities of the broad-spectrum β-lactamase inhibitor taniborbactam against metallo-β-lactamases

Taniborbactam (TAN) is a novel broad-spectrum beta-lactamase inhibitor with significant activity against subclass B1 metallo-beta-lactamases (MBLs). Here, we showed that TAN exhibited an overall excellent activity against B1 MBLs including most NDM- and VIM-like as well as SPM-1, GIM-1, and DIM-1 enzymes, but not against SIM-1. Noteworthy, VIM-1-like enzymes (particularly VIM-83) were less inhibited by TAN than VIM-2-like. Like NDM-9, NDM-30 (also differing from NDM-1 by a single amino acid substitution) was resistant to TAN.

Automated summary

Taniborbactam showed excellent activity against B1 MBLs, except for SIM-1. VIM-1-like enzymes, particularly VIM-83, were less inhibited by Taniborbactam compared to VIM-2-like.