4.4 Article

Population-Based Survival Analysis of Stage IVB Small-Cell Neuroendocrine Carcinoma in Comparison to Major Histological Subtypes of Cervical Cancer

Journal

CURRENT ONCOLOGY
Volume 30, Issue 11, Pages 9428-9436

Publisher

MDPI
DOI: 10.3390/curroncol30110682

Keywords

cervical cancer; stage IVB; survival; SCNEC; population-based study

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The aim of this study was to compare the survival outcomes of different histological subtypes of cervical cancer in stage IVB. The results indicated that patients with small-cell neuroendocrine carcinoma (SCNEC) had the shortest survival. Furthermore, SCNEC was associated with significantly decreased survival compared to other histological subtypes, except for those treated with surgery.
The aim of the current study is to investigate the survival outcome of stage IVB SCNEC of the uterine cervix in comparison to major histological subtypes of cervical cancer. A population-based retrospective cohort study was conducted using the Osaka Cancer Registry data from 1994 to 2018. All FIGO 2009 stage IVB cervical cancer patients who displayed squamous cell carcinoma (SCC), adenocarcinoma (A), adenosquamous cell carcinoma (AS), or small-cell neuroendocrine carcinoma (SCNEC) were first identified. The patients were classified into groups according to the types of primary treatment. Then, their survival rates were examined using the Kaplan-Meier method. Overall, in a total of 1158 patients, clearly differential survival rates were observed according to the histological subtypes, and SCNEC was associated with shortest survival. When examined according to the types of primary treatments, SCNEC was associated with significantly decreased survival when compared to SCC or A/AS, except for those treated with surgery. In patients with FIGO 2009 stage IVB cervical cancer, SCNEC was associated with decreased survival when compared to SCC or A/AS. Although current treatments with either surgery, chemotherapy or radiotherapy have some therapeutic efficacies, to improve the prognosis, novel effective treatments specifically targeting cervical SCNEC need to be developed.

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