☆ 4.7 Review

Astrocytes: Lessons Learned from the Cuprizone Model

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Astrocyte-Derived BDNF Supports Myelin Protein Synthesis after Cuprizone-Induced Demyelination

Clifton G. Fulmer et al.

JOURNAL OF NEUROSCIENCE (2014)

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Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

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FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

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Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain

Abolfazl Azami Tameh et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2013)

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Article Clinical Neurology

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

Thomas Skripuletz et al.

BRAIN (2013)

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Regional Heterogeneity of Cuprizone-Induced Demyelination: Topographical Aspects of the Midline of the Corpus Callosum

T. Schmidt et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2013)

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Loss of Branched O-Mannosyl Glycans in Astrocytes Accelerates Remyelination

Kenji Kanekiyo et al.

JOURNAL OF NEUROSCIENCE (2013)

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Cuprizone short-term exposure: Astrocytic IL-6 activation and behavioral changes relevant to psychosis

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NEUROBIOLOGY OF DISEASE (2013)

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Investigation of Sequential Growth Factor Delivery during Cuprizone Challenge in Mice Aimed to Enhance Oligodendrogliogenesis and Myelin Repair

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PLOS ONE (2013)

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Review Neurosciences

BMP-Smad 1/5/8 signalling in the development of the nervous system

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PROGRESS IN NEUROBIOLOGY (2013)

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Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS

Jigisha R. Patel et al.

ACTA NEUROPATHOLOGICA (2012)

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Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination

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ACTA NEUROPATHOLOGICA (2012)

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Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination

Lorraine W. Lau et al.

ANNALS OF NEUROLOGY (2012)

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Astrogliosis during acute and chronic cuprizone demyelination and implications for remyelination

Norah Hibbits et al.

ASN NEURO (2012)

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Aberrant Upregulation of Astroglial Ceramide Potentiates Oligodendrocyte Injury

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BRAIN PATHOLOGY (2012)

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Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination

Lucas Silvestroff et al.

EXPERIMENTAL NEUROLOGY (2012)

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Article Biochemistry & Molecular Biology

Inflammatory Response and Chemokine Expression in the White Matter Corpus Callosum and Gray Matter Cortex Region During Cuprizone-Induced Demyelination

J. P. Buschmann et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2012)

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IL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination

Zizhen Kang et al.

JOURNAL OF NEUROSCIENCE (2012)

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Article Multidisciplinary Sciences

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Ursula Fuenfschilling et al.

NATURE (2012)

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Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment?

Elke Verena Voss et al.

NEUROBIOLOGY OF DISEASE (2012)

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Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication

Andrew J. Steelman et al.

NEUROSCIENCE RESEARCH (2012)

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Article Clinical Neurology

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system

Jenni Raasch et al.

BRAIN (2011)

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BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions

M. Kipp et al.

BRAIN BEHAVIOR AND IMMUNITY (2011)

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Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function

L. A. Pasquini et al.

CELL DEATH AND DIFFERENTIATION (2011)

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Evaluation of [123I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation

Filomena Mattner et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2011)

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Glial Amyloid Precursor Protein Expression is Restricted to Astrocytes in an Experimental Toxic Model of Multiple Sclerosis

Tim Clarner et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2011)

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Matrix Metalloproteinases and Their Tissue Inhibitors in Cuprizone-Induced Demyelination and Remyelination of Brain White and Gray Matter

Jelena Skuljec et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)

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Retinoid X receptor gamma signaling accelerates CNS remyelination

Jeffrey K. Huang et al.

NATURE NEUROSCIENCE (2011)

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Intravenous administration of human embryonic stem cell-derived neural precursor cells attenuates cuprizone-induced central nervous system (CNS) demyelination

S. J. Crocker et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2011)

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Spatial and Temporal Profiles of Growth Factor Expression during CNS Demyelination Reveal the Dynamics of Repair Priming

Viktoria Gudi et al.

PLOS ONE (2011)

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Time-dependent changes in the brain arachidonic acid cascade during cuprizone-induced demyelination and remyelination

S. Palumbo et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2011)

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Cerebellar Cortical Demyelination in the Murine Cuprizone Model

Thomas Skripuletz et al.

BRAIN PATHOLOGY (2010)

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ADAM12 is expressed by astrocytes during experimental demyelination

Fabian Baertling et al.

BRAIN RESEARCH (2010)

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Age-Related and Cuprizone-Induced Changes in Myelin and Transcription Factor Gene Expression and in Oligodendrocyte Cell Densities in the Rostral Corpus Callosum of Mice

J. Ronald Doucette et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2010)

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Dynamic Expression of Cx47 in Mouse Brain Development and in the Cuprizone Model of Myelin Plasticity

Rosalba Parenti et al.

GLIA (2010)

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Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone-induced demyelination

Holly S. Cate et al.

JOURNAL OF NEUROCHEMISTRY (2010)

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CNS-specific expression of C3a and C5a exacerbate demyelination severity in the cuprizone model

Sarah A. Ingersoll et al.

MOLECULAR IMMUNOLOGY (2010)

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CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination

Jigisha R. Patel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Propagation of Spreading Depression Inversely Correlates with Cortical Myelin Content

Doron Merkler et al.

ANNALS OF NEUROLOGY (2009)

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Regional differences between grey and white matter in cuprizone induced demyelination

Viktoria Gudi et al.

BRAIN RESEARCH (2009)

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Cuprizone Treatment Induces Demyelination and Astrocytosis in the Mouse Hippocampus

Akvile Norkute et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2009)

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Demyelination of the hippocampus is prominent in the cuprizone model

Paraskevi N. Koutsoudaki et al.

NEUROSCIENCE LETTERS (2009)

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Remyelination in the CNS: from biology to therapy

Robin J. M. Franklin et al.

NATURE REVIEWS NEUROSCIENCE (2008)

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Activation of Inflammatory Response by a Combination of Growth Factors in Cuprizone-Induced Demyelinated Brain Leads to Myelin Repair

Juan Carlos Biancotti et al.

NEUROCHEMICAL RESEARCH (2008)

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Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica

S. R. Hinson et al.

NEUROLOGY (2007)

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Expression of an Acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination

Si-Young Song et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2007)

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Astrocyte-specific expression of a soluble form of the murine complement control protein crry confers demyelination protection in the cuprizone model

Dustin T. Briggs et al.

GLIA (2007)

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Platelet-derived growth factor promotes repair of chronically demyelinated white matter

Adam C. Vana et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)

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Astrocytes - Friends or foes in multiple sclerosis

Anna Williams et al.

GLIA (2007)

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The neurotoxic effect of cuprizone on oligodendrocytes depends on the presence of pro-inflammatory cytokines secreted by microglia

L. A. Pasquini et al.

NEUROCHEMICAL RESEARCH (2007)

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T cells contribute to lysophosphatidylcholine-induced macrophage activation and demyelination in the CNS

Nader Ghasemlou et al.

GLIA (2007)

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Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination

Ming-Kai Chen et al.

TOXICOLOGICAL SCIENCES (2006)

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Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice

K. -A. Irvine et al.

JOURNAL OF NEUROIMMUNOLOGY (2006)

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GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS

KB Casper et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2006)

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IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel

VA Lennon et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

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Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment

P Zatta et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2005)

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Astroglial-derived lymphotoxin-alpha exacerbates inflammation and demyelination, but not remyelination

SR Plant et al.

GLIA (2005)

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Interlaminar astroglia of the cerebral cortex: a marker of the primate brain

JA Colombo et al.

BRAIN RESEARCH (2004)

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Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro

R Selvaraju et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2004)

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Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination

RH Woodruff et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2004)

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Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination

MF Stidworthy et al.

BRAIN (2004)

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Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization

MK Chen et al.

BRAIN (2004)

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Interleukin-1β promotes repair of the CNS

JL Mason et al.

JOURNAL OF NEUROSCIENCE (2001)

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Absence of macrophage-inflammatory protein-1α delays central nervous system demyelination in the presence of an intact blood-brain barrier

EJ McMahon et al.

JOURNAL OF IMMUNOLOGY (2001)

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Interferon-γ protects against cuprizone-induced demyelination

X Gao et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2000)

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Insulin-like growth factor-1 fails to enhance central nervous system myelin repair during autoimmune demyelination

B Cannella et al.

AMERICAN JOURNAL OF PATHOLOGY (2000)

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