Related references
Note: Only part of the references are listed.Protective effects of the Terminalia bellirica tannin-induced Nrf2/HO-1 signaling pathway in rats with high-altitude pulmonary hypertension
Salamaiti Aimaier et al.
BMC COMPLEMENTARY MEDICINE AND THERAPIES (2023)
Puerarin-V prevents the progression of hypoxia- and monocrotaline-induced pulmonary hypertension in rodent models
Di Chen et al.
ACTA PHARMACOLOGICA SINICA (2022)
Research Progress on Pulmonary Arterial Hypertension and the Role of the Angiotensin Converting Enzyme 2-Angiotensin-(1-7)-Mas Axis in Pulmonary Arterial Hypertension
Feng Zhang et al.
CARDIOVASCULAR DRUGS AND THERAPY (2022)
Sulforaphane Does Not Protect Right Ventricular Systolic and Diastolic Functions in Nrf2 Knockout Pulmonary Artery Hypertension Mice
Guangyan Zhang et al.
CARDIOVASCULAR DRUGS AND THERAPY (2022)
Sodium tanshinone IIA sulfonate enhances the BMP9-BMPR2-Smad1/5/9 signaling pathway in rat pulmonary microvascular endothelial cells and human embryonic stem cell-derived endothelial cells
Jian Wang et al.
BIOCHEMICAL PHARMACOLOGY (2022)
Myeloid-cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice
Marija Gredic et al.
EUROPEAN RESPIRATORY JOURNAL (2022)
Tannins in Terminalia bellirica inhibits hepatocellular carcinoma growth via re-educating tumor-associated macrophages and restoring CD8+T cell function
Zihao Chang et al.
BIOMEDICINE & PHARMACOTHERAPY (2022)
Dysregulation of BMP9/BMPR2/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats
Qian Jiang et al.
BRITISH JOURNAL OF PHARMACOLOGY (2021)
Resveratrol: Mechanistic and therapeutic perspectives in pulmonary arterial hypertension
Elaheh Mirhadi et al.
PHARMACOLOGICAL RESEARCH (2021)
Nrf2 regulates cell motility through RhoA-ROCK1 signalling in non-small-cell lung cancer cells
Eunsun Ko et al.
SCIENTIFIC REPORTS (2021)
Protective effect of baicalin against pulmonary arterial hypertension vascular remodeling through regulation of TNF-α signaling pathway
Xia Xue et al.
PHARMACOLOGY RESEARCH & PERSPECTIVES (2021)
Endothelial cells in the pathogenesis of pulmonary arterial hypertension
Colin E. Evans et al.
EUROPEAN RESPIRATORY JOURNAL (2021)
Rosiglitazone Prevents Autophagy by Regulating Nrf2-Antioxidant Response Element in a Rat Model of Lithium-pilocarpine-induced Status Epilepticus
Ying Peng et al.
NEUROSCIENCE (2021)
ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension
Dan Li et al.
CIRCULATION (2021)
The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism
Moon-Young Song et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Delivery of Cinnamic Aldehyde Antioxidant Response Activating nanoParticles (ARAPas) for Vascular Applications
Ana E. Cartaya et al.
ANTIOXIDANTS (2021)
Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata sensitizes prostate cancer cells in vitro and in vivo
Suvranil Ghosh et al.
FREE RADICAL BIOLOGY AND MEDICINE (2021)
Bioactive Compounds From Coptidis Rhizoma Alleviate Pulmonary Arterial Hypertension by Inhibiting Pulmonary Artery Smooth Muscle Cells' Proliferation and Migration
Shuai Luo et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2021)
Oxidative and pro-inflammatory lung injury induced by desflurane inhalation in rats and the protective effect of rutin
Mustafa Tosun et al.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2021)
Curcumin Improves Pulmonary Hypertension Rats by Regulating Mitochondrial Function
Jing Chen et al.
BIOMED RESEARCH INTERNATIONAL (2021)
5-Hydroxymaltol Derived from Beetroot Juice through Lactobacillus Fermentation Suppresses Inflammatory Effect and Oxidant Stress via Regulating NF-kB, MAPKs Pathway and NRF2/HO-1 Expression
Su-Lim Kim et al.
ANTIOXIDANTS (2021)
Puerarin suppresses inflammation and ECM degradation through Nrf2/HO-1 axis in chondrocytes and alleviates pain symptom in osteoarthritic mice
Ximiao Chen et al.
FOOD & FUNCTION (2021)
Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation
Crissey L. Pascale et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)
Nrf2-mediated cytoprotective effect of four different hyaluronic acids by molecular weight in human tenocytes
Marialucia Gallorini et al.
JOURNAL OF DRUG TARGETING (2020)
Nrf2-ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms
Pallab Shaw et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2020)
Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension
Patrick Turck et al.
NUTRITION (2020)
Berberine Attenuates Cholesterol Accumulation in Macrophage Foam Cells by Suppressing AP-1 Activity and Activation of the Nrf2/HO-1 Pathway
Xue-Juan Yang et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)
Therapeutic and biological activities of berberine: The involvement of Nrf2 signaling pathway
Milad Ashrafizadeh et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2020)
Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension
Yin Kang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)
Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer - contradictory effects and future perspectives
Parham Jabbarzadeh Kaboli et al.
BIOMEDICINE & PHARMACOTHERAPY (2020)
Protective effects of resveratrol and SR1001 on hypoxia-induced pulmonary hypertension in rats
Cheng Li et al.
CLINICAL AND EXPERIMENTAL HYPERTENSION (2020)
Berberine alleviates pulmonary hypertension through Trx1 and beta-catenin signaling pathways in pulmonary artery smooth muscle cells
Yu Wande et al.
EXPERIMENTAL CELL RESEARCH (2020)
Hypoxia induces an increase in intestinal permeability and pulmonary arterial pressures in neonatal Holstein calves despite feeding the flavonoid rutin
Nicholas W. Shellenberger et al.
JOURNAL OF DAIRY SCIENCE (2020)
Association of Lactate Dehydrogenase with In-Hospital Mortality in Patients with Acute Aortic Dissection: A Retrospective Observational Study
Huaping He et al.
INTERNATIONAL JOURNAL OF HYPERTENSION (2020)
Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF-β1/α-SMA/Col I and III pathway
Linlin Bai et al.
BIOFACTORS (2020)
Regulation of KCNMA1 transcription by Nrf2 in coronary arterial smooth muscle cells
Xiaojing Sun et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)
Redox toxicology of environmental chemicals causing oxidative stress
Fuli Zheng et al.
REDOX BIOLOGY (2020)
The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives
Emiliano Panieri et al.
BIOMOLECULES (2020)
The role of inflammation in a rat model of chronic thromboembolic pulmonary hypertension induced by carrageenan
Dawen Wu et al.
ANNALS OF TRANSLATIONAL MEDICINE (2020)
Oltipraz Prevents High Glucose-Induced Oxidative Stress and Apoptosis in RSC96 Cells through the Nrf2/NQO1 Signalling Pathway
Zengxin Jiang et al.
BIOMED RESEARCH INTERNATIONAL (2020)
NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
Angel Cores et al.
BIOMOLECULES (2020)
Resveratrol prevented experimental pulmonary vascular remodeling via miR-638 regulating NR4A3/cyclin D1 pathway
Ying-Ying Liu et al.
MICROVASCULAR RESEARCH (2020)
Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell-Dependent Endothelial Cell Apoptosis
Gregoire Ruffenach et al.
HYPERTENSION (2020)
Oxidative Stress, Kinase Activity and Inflammatory Implications in Right Ventricular Hypertrophy and Heart Failure under Hypobaric Hypoxia
Eduardo Pena et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Proteomic Analysis of KCNK3 Loss of Expression Identified Dysregulated Pathways in Pulmonary Vascular Cells
Helene Le Ribeuz et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Endothelial to mesenchymal transition during neonatal hyperoxia-induced pulmonary hypertension
Jiannan Gong et al.
JOURNAL OF PATHOLOGY (2020)
Activation of M3AChR (Type 3 Muscarinic Acetylcholine Receptor) and Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2) Signaling by Choline Alleviates Vascular Smooth Muscle Cell Phenotypic Switching and Vascular Remodeling
Xi He et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)
Current Status on Immunological Therapies for Type 1 Diabetes Mellitus
Griselda Lim Loo Xin et al.
CURRENT DIABETES REPORTS (2019)
Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice
Hye-Youn Cho et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)
Z-Ligustilide protects vascular endothelial cells from oxidative stress and rescues high fat diet-induced atherosclerosis by activating multiple NRF2 downstream genes
Yao Zhu et al.
ATHEROSCLEROSIS (2019)
Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension
Melanie Lambert et al.
CIRCULATION RESEARCH (2019)
New developments in pharmacotherapy for Friedreich ataxia
Alexandra Clay et al.
EXPERT OPINION ON PHARMACOTHERAPY (2019)
Lipoxin A4 restores oxidative stress-induced vascular endothelial cell injury and thrombosis-related factor expression by its receptor-mediated activation of Nrf2-HO-1 axis
Songbai Yang et al.
CELLULAR SIGNALLING (2019)
Puerarin prevents progression of experimental hypoxia-induced pulmonary hypertension via inhibition of autophagy
Xiaodan Zhang et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2019)
Naringenin-induced HO-1 ameliorates high glucose or free fatty acids-associated apoptosis via PI3K and JNK/Nrf2 pathways in human umbilical vein endothelial cells
Jian Feng et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
Nrf-2 signaling inhibits intracranial aneurysm formation and progression by modulating vascular smooth muscle cell phenotype and function
Yuan Shi et al.
JOURNAL OF NEUROINFLAMMATION (2019)
The Nrf2/HO-1 Axis as Targets for Flavanones: Neuroprotection by Pinocembrin, Naringenin, and Eriodictyol
Solomon Habtemariam
Oxidative Medicine and Cellular Longevity (2019)
Inhaled combination of sildenafil and rosiglitazone improves pulmonary hemodynamics, cardiac function, and arterial remodeling
Jahidur Rashid et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)
Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases
Zoltan Ungvari et al.
GEROSCIENCE (2019)
Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension
Ly Tu et al.
CIRCULATION RESEARCH (2019)
Risk stratification and medical therapy of pulmonary arterial hypertension
Nazzareno Galie et al.
EUROPEAN RESPIRATORY JOURNAL (2019)
Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype
Stefano Tarantini et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2018)
Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure
Changhai Tian et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)
Serotonin 2A receptor inhibition protects against the development of pulmonary hypertension and pulmonary vascular remodeling in neonatal mice
Cassidy Delaney et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)
Danshensu prevents hypoxic pulmonary hypertension in rats by inhibiting the proliferation of pulmonary artery smooth muscle cells via TGF-beta-smad3-associated pathway
Ning Zhang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2018)
Fasudil alleviates pressure overload-induced heart failure by activating Nrf2-mediated antioxidant responses
Peng Guan et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2018)
Repurposing rosiglitazone, a PPAR-γ agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH
Jahidur Rashid et al.
JOURNAL OF CONTROLLED RELEASE (2018)
Pulmonary arterial hypertension: pathogenesis and clinical management
Thenappan Thenappan et al.
BMJ-BRITISH MEDICAL JOURNAL (2018)
Pulmonary arterial hypertension: pathogenesis and clinical management
Thenappan Thenappan et al.
BMJ-BRITISH MEDICAL JOURNAL (2018)
Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.
Antonio Cuadrado et al.
REDOX BIOLOGY (2018)
Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension
Thenappan Thenappan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)
Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation
Rou-Ling Cho et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation
Wenhua Shi et al.
LIFE SCIENCES (2018)
Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review
Matej Sova et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2018)
Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty rats
Nicholas E. Buglak et al.
REDOX BIOLOGY (2018)
Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?
Melanie Lambert et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Prenatal treatment with rosiglitazone attenuates vascular remodeling and pulmonary monocyte influx in experimental congenital diaphragmatic hernia
Jan-Hendrik Gosemann et al.
PLOS ONE (2018)
Rho kinase and Na+/H+ exchanger mediate endothelin-1-induced pulmonary arterial smooth musclecell proliferation and migration
John C. Huetsch et al.
PHYSIOLOGICAL REPORTS (2018)
BMPR2 mutations and endothelial dysfunction in pulmonary arterial hypertension (2017 Grover Conference Series)
Andrea Frump et al.
PULMONARY CIRCULATION (2018)
Endothelial-to-mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awry
Gonzalo Sanchez-Duffhues et al.
DEVELOPMENTAL DYNAMICS (2018)
Andrographolide inhibits hypoxia-induced HIF-1-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells
Hung-Chih Lin et al.
ENVIRONMENTAL TOXICOLOGY (2017)
Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol
Yucai Chen et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)
Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy
Melissa A. Lyle et al.
FRONTIERS IN PHYSIOLOGY (2017)
A Combination of Podophyllotoxin and Rutin Alleviates Radiation-Induced Pneumonitis and Fibrosis through Modulation of Lung Inflammation in Mice
Savita Verma et al.
FRONTIERS IN IMMUNOLOGY (2017)
Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways
Agnieszka P. Grzegorzewska et al.
SCIENTIFIC REPORTS (2017)
Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus
Xiao-Jie Zhao et al.
BRAIN RESEARCH BULLETIN (2017)
Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis
Qian Jiang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)
Activation of Nrf2 contributes to the protective effect of Exendin-4 against angiotensin II-induced vascular smooth muscle cell senescence
Tengfei Zhou et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)
Endothelial-to-Mesenchymal Transition An Evolving Paradigm and a Promising Therapeutic Target in PAH
Kurt R. Stenmark et al.
CIRCULATION (2016)
Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension
Fabrice Antigny et al.
CIRCULATION (2016)
Resveratrol alleviate hypoxic pulmonary hypertension via anti-inflammation and anti-oxidant pathways in rats
Dunquan Xu et al.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2016)
Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice
Noha M. Shawky et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2016)
Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO-cGMP -PKG-KATPChannel Signaling Pathway
Marilia F. Manchope et al.
PLOS ONE (2016)
Microparticulate/nanoparticulate powders of a novel Nrf2 activator and an aerosol performance enhancer for pulmonary delivery targeting the lung Nrf2/Keap-1 pathway
Priya Muralidharan et al.
MOLECULAR SYSTEMS DESIGN & ENGINEERING (2016)
Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats
Apurva A. Javkhedkar et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2015)
A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response
Tao Shen et al.
ANTIOXIDANTS & REDOX SIGNALING (2015)
BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension
Isabel Diebold et al.
CELL METABOLISM (2015)
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
Nazzareno Galie et al.
EUROPEAN RESPIRATORY JOURNAL (2015)
Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP
Antonio Cuadrado
FREE RADICAL BIOLOGY AND MEDICINE (2015)
Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
Yang Bai et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)
Tanshinone IIA attenuates hypoxic pulmonary hypertension via modulating Kv currents
Lianhe Zheng et al.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2015)
Curcumin analogues inhibit phosphodiesterase-5 and dilate rat pulmonary arteries
Oraya Kruangtip et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2015)
Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling
Bernadette Chen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2014)
Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension
Marc Humbert et al.
CIRCULATION (2014)
Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension
Marlene Rabinovitch et al.
CIRCULATION RESEARCH (2014)
Basigin Mediates Pulmonary Hypertension by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation
Kimio Satoh et al.
CIRCULATION RESEARCH (2014)
Naringenin adds to the protective effect of L-arginine in monocrotaline-induced pulmonary hypertension in rats: Favorable modulation of oxidative stress, inflammation and nitric oxide
Lamiaa A. Ahmed et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2014)
Oxymatrine prevents hypoxia- and monocrotaline-induced pulmonary hypertension in rats
Bo Zhang et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Effects of PPAR-γ Agonist Treatment on LPS-Induced Mastitis in Rats
Ding Mingfeng et al.
INFLAMMATION (2014)
Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α
Xiangjun Ji et al.
INTERNATIONAL JOURNAL OF CANCER (2014)
Maslinic acid protects vascular smooth muscle cells from oxidative stress through Akt/Nrf2/HO-1 pathway
Xiaofei Qin et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2014)
Antioxidant Mechanism of Rutin on Hypoxia-Induced Pulmonary Arterial Cell Proliferation
Qian Li et al.
MOLECULES (2014)
Epigallocatechin Gallate Attenuates Proliferation and Oxidative Stress in Human Vascular Smooth Muscle Cells Induced by Interleukin-1β via Heme Oxygenase-1
Po-Len Liu et al.
MEDIATORS OF INFLAMMATION (2014)
Sulforaphane treatment of autism spectrum disorder (ASD)
Kanwaljit Singh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Rosiglitazone Attenuated Endothelin-1-Induced Vasoconstriction of Pulmonary Arteries in the Rat Model of Pulmonary Arterial Hypertension via Differential Regulation of ET-1 Receptors
Yahan Liu et al.
PPAR RESEARCH (2014)
The Nuclear Factor Erythroid 2-Related Factor 2 Activator Oltipraz Attenuates Chronic Hypoxia-Induced Cardiopulmonary Alterations in Mice
Shunsuke Eba et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)
Sodium Tanshinone IIA Sulfonate Inhibits Canonical Transient Receptor Potential Expression in Pulmonary Arterial Smooth Muscle from Pulmonary Hypertensive Rats
Jian Wang et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)
Role of Nrf2 in Oxidative Stress and Toxicity
Qiang Ma
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)
Antioxidants for the Treatment of Patients with Severe Angioproliferative Pulmonary Hypertension?
Norbert F. Voelkel et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
Sequestosome1/p62: A regulator of redox-sensitive voltage-activated potassium channels, arterial remodeling, inflammation, and neurite outgrowth
Tetsuro Ishii et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension
Rubin M. Tuder et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)
Kinase-dependent activation of voltage-gated Ca2+ channels by ET-1 in pulmonary arterial myocytes during chronic hypoxia
Trevor Luke et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)
Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Yoichiro Mitsuishi et al.
CANCER CELL (2012)
Inflammation in Pulmonary Arterial Hypertension
Laura C. Price et al.
CHEST (2012)
An Evaluation of Long-term Survival From Time of Diagnosis in Pulmonary Arterial Hypertension From the REVEAL Registry
Raymond L. Benza et al.
CHEST (2012)
Tissue localization of nanoparticles is altered due to hypoxia resulting in poor efficacy of curcumin nanoparticles in pulmonary hypertension
Venkat Ratnam Devadasu et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2012)
55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: Role of HIF-1
Larissa A. Shimoda
JOURNAL OF APPLIED PHYSIOLOGY (2012)
Molecular pathogenesis of pulmonary arterial hypertension
Marlene Rabinovitch
JOURNAL OF CLINICAL INVESTIGATION (2012)
Endothelin-1 Augments Na+/H+ Exchange Activity in Murine Pulmonary Arterial Smooth Muscle Cells via Rho Kinase
Clark Undem et al.
PLOS ONE (2012)
Endothelial-mesenchymal transition and its contribution to the emergence of stem cell phenotype
Damian Medici et al.
SEMINARS IN CANCER BIOLOGY (2012)
Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response
Yi Zheng et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)
Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: A potential role for atrogin-1 in smooth muscle
Michael L. Paffett et al.
VASCULAR PHARMACOLOGY (2012)
Hypoxia. 4. Hypoxia and ion channel function
Larissa A. Shimoda et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)
Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response
Zoltan Ungvari et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)
HIF and the Lung Role of Hypoxia-inducible Factors in Pulmonary Development and Disease
Larissa A. Shimoda et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)
Silencing of Sodium-Hydrogen Exchanger 1 Attenuates the Proliferation, Hypertrophy, and Migration of Pulmonary Artery Smooth Muscle Cells via E2F1
Lunyin Yu et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)
Lung Extracellular Superoxide Dismutase Overexpression Lessens Bleomycin-Induced Pulmonary Hypertension and Vascular Remodeling
Zachary Van Rheen et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)
Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo
Yi Tan et al.
DIABETES (2011)
Simvastatin protects against the development of monocrotaline-induced pulmonary hypertension in rats via a heme oxygenase-1-dependent pathway
Wei-hua Zhang et al.
EXPERIMENTAL LUNG RESEARCH (2011)
Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
Brooks M. Hybertson et al.
MOLECULAR ASPECTS OF MEDICINE (2011)
Xanthine Oxidase-Derived ROS Upregulate Egr-1 via ERK1/2 in PA Smooth Muscle Cells; Model to Test Impact of Extracellular ROS in Chronic Hypoxia
Tanya Hartney et al.
PLOS ONE (2011)
Mesenchymal Stromal Cells Expressing Heme Oxygenase-1 Reverse Pulmonary Hypertension
Olin D. Liang et al.
STEM CELLS (2011)
Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α
Xiangrong Zuo et al.
JOURNAL OF BIOMEDICAL RESEARCH (2011)
Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
Zoltan Ungvari et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)
Rosiglitazone Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension in a Mouse Model
Rachel E. Nisbet et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)
Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview
Ken Itoh et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era
Marc Humbert et al.
CIRCULATION (2010)
Resveratrol inhibits right ventricular hypertrophy induced by monocrotaline in rats
Dan-Li Yang et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2010)
Tanshinone IIA modulates pulmonary vascular response to agonist and hypoxia primarily via inhibiting Ca2+ influx and release in normal and hypoxic pulmonary hypertension rats
Jing Wang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz
Song Hwa Choi et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2010)
Rosiglitazone attenuates hypoxia-induced pulmonary arterial hypertension in rats
Eun Kyung Kim et al.
RESPIROLOGY (2010)
Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension
I. Morecroft et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia
Ju-Young Kim et al.
CARDIOVASCULAR RESEARCH (2009)
Guidelines for the diagnosis and treatment of pulmonary hypertension
Nazzareno Galie et al.
EUROPEAN HEART JOURNAL (2009)
The science of endothelin-1 and endothelin receptor antagonists in the management of pulmonary arterial hypertension: current understanding and future studies
N. J. Davie et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2009)
Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats
Anna Csiszar et al.
HYPERTENSION (2009)
C-Reactive Protein A New Predictor of Adverse Outcome in Pulmonary Arterial Hypertension
Rozenn Quarck et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
Impaired Voltage Gated Potassium Channel Responses in a Fetal Lamb Model of Persistent Pulmonary Hypertension of the Newborn
Girija G. Konduri et al.
PEDIATRIC RESEARCH (2009)
Pathology of Pulmonary Arterial Hypertension
Rubin M. Tuder
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2009)
Pulmonary hypertension
Gorev Grubu Uyeleri et al.
TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY (2009)
Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes
E. Miles Whitman et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)
Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells
Richard S. Sacks et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)
Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension
Kathryn N. Farrow et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)
Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling
Eva Nozik-Grayck et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)
Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats
Fumihiko Kamezaki et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)
Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications
E. D. Burg et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Rosiglitazone but not losartan prevents Nrf-2 dependent CD36 gene expression up-regulation in an in vivo atherosclerosis model
Y. Hernandez-Trujillo et al.
CARDIOVASCULAR DIABETOLOGY (2008)
PDE5 inhibitors for cystic fibrosis: can they also enhance chloride transport?
Sabina A. Antoniu
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2008)
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
Sebastien Bonnet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Potassium channel diversity in the pulmonary arteries and pulmonary veins: Implications for regulation of the pulmonary vasculature in health and during pulmonary hypertension
Sebastien Bonnet et al.
PHARMACOLOGY & THERAPEUTICS (2007)
Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells
Hong-Sheng Zhang et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo
Anna-Liisa Levonen et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling
Joseph T. Crossno et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2007)
Impact of TASK-1 in human pulmonary artery smooth muscle cells
A Olschewski et al.
CIRCULATION RESEARCH (2006)
Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase
ML Sentman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Mechanistic studies of the Nrf2-Keap1 signaling pathway
Donna D. Zhang
DRUG METABOLISM REVIEWS (2006)
Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species-induced cell injury
H Zhu et al.
FEBS LETTERS (2005)
Endothelial dysfunction in pulmonary hypertension
R Budhiraja et al.
CIRCULATION (2004)
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
SB Cullinan et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
A Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Coronary-artery revascularization before elective major vascular surgery
EO McFalls et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles
K Itoh et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Thromboxane A2-induced inhibition of voltage-gated K+ channels and pulmonary vasoconstriction -: Role of protein kinase Cζ
A Cogolludo et al.
CIRCULATION RESEARCH (2003)
Curcurnin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
E Balogun et al.
BIOCHEMICAL JOURNAL (2003)
In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction chronically hypoxic rats
ZI Pozeg et al.
CIRCULATION (2003)
Herne oxygenase-1 reduces murine monocrotaline-induced pulmonary inflammatory responses and resultant right ventricular overload
J Goto et al.
ANTIOXIDANTS & REDOX SIGNALING (2002)
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
C Atkinson et al.
CIRCULATION (2002)
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats - Role of increased expression and activity of voltage-gated potassium channels
ED Michelakis et al.
CIRCULATION (2002)
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
T Minamino et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
TASK-5, a new member of the tandem-pore K+ channel family
D Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
JY Chan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2000)
Primary pulmonary hypertension - A vascular biology and translational research work in progress
S Archer et al.
CIRCULATION (2000)
Chronic intrauterine pulmonary hypertension decreases calcium-sensitive potassium channel mRNA expression
DN Cornfield et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2000)
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
JD Hayes et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2000)
Share Paper
