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Atomic force microscopy in disease-related studies: Exploring tissue and cell mechanics

MICROSCOPY RESEARCH AND TECHNIQUE (2023)

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Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Kewen Lei et al.

Summary: The study demonstrates that cancer cells enriched in cholesterol inhibit T-cell-mediated cytotoxicity, while stiffening cancer cells through cholesterol depletion enhances T-cell cytotoxicity, thereby improving the efficacy of adoptive T-cell therapy. This enhancement is attributed to increased T-cell forces at the immunological synapse, rather than influencing other T-cell functions like receptor signaling or production of cytolytic proteins. These findings suggest a mechanical immune checkpoint that could be targeted for improving cancer immunotherapies.

NATURE BIOMEDICAL ENGINEERING (2021)

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Review Multidisciplinary Sciences

The changing landscape of atherosclerosis

Peter Libby

Summary: Emerging evidence has led to a significant evolution of concepts related to atherosclerosis, with a shifting risk profile that is no longer limited to specific regions or demographics. Recent research has highlighted new risk factors and mechanisms underlying atherosclerosis, opening doors to potential therapeutic interventions for this widespread disease.

NATURE (2021)

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Article Ophthalmology

Effective elastic modulus of an intact cornea related to indentation behavior: A comparison between the Hertz model and Johnson-Kendall-Roberts model

QiaoMei Ren et al.

Summary: A macro-indentation test was performed on intact cornea to analyze its behavior under physiological pressures, with the JKR model providing more accurate elastic modulus values than the Hertz model, due to its consideration of adhesion energy. This study indicates that the JKR model could be effectively used to obtain E values of intact cornea under physiological pressures.

EXPERIMENTAL EYE RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Nanomechanical Hallmarks of Helicobacter pylori Infection in Pediatric Patients

Piotr Deptula et al.

Summary: This study focuses on the molecular mechanisms related to Helicobacter pylori infection and gastric cancer development. It suggests that the nanomechanical properties of infected tissues could serve as markers of H. pylori presence and the mechanical response of gastric cells to this infection may play a role in promoting cancer development.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Contact probing of prestressed adhesive membranes of living cells

Feodor M. Borodich et al.

Summary: Atomic force microscopy (AFM) is a main experimental tool for studying living biological cells and extracting information about their structural and mechanical properties. Proper modelling of AFM probing and adhesive contact problems is crucial for interpreting experimental data. This study focuses on the effects of molecular adhesion on living cells, considering the mechanical properties of cell membranes under tensile prestress. An extended method for extracting elastic and adhesive properties of contacted materials is proposed for cell probing experiments. The results can be applied to smooth cells and processes where adhesion is important.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2021)

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Article Chemistry, Physical

Estrogen Modulates Epithelial Breast Cancer Cell Mechanics and Cell-to-Cell Contacts

Barbara Zbiral et al.

Summary: The study found that estrogen softens MCF-7 breast cancer cells, while cells in hormone-free medium lead to an increase in elastic and viscoelastic moduli. Additionally, cells cultured under estrogenic conditions show changes in E-cadherin distribution and weakened cell-cell contacts.

MATERIALS (2021)

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Article Oncology

Atomic Force Microscope Nanoindentation Analysis of Diffuse Astrocytic Tumor Elasticity: Relation with Tumor Histopathology

Abraham Tsitlakidis et al.

Summary: Biomechanics plays a key role in diffuse glioma progression, with glioma cells interacting chemically and mechanically with the extracellular matrix to affect proliferation and migration. Isocitrate dehydrogenase gene family mutations and WHO grade impact glioma elasticity, and AFM nanoindentation helps measure tissue elasticity. Different glioma types show varying responses in terms of tissue elasticity, indicating further research is needed to understand patient heterogeneity.

CANCERS (2021)

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Article Engineering, Biomedical

The Micromechanical Signature of Pituitary Adenomas: New Perspectives for the Diagnosis and Surgery

Mikael Meyer et al.

Summary: Pituitary adenomas are common tumors in the skull base that require surgical resection to improve symptoms, but difficulties in locating the tumors exist. Recent research shows a significant difference in stiffness between tumor tissues and normal tissues, which can be used for intraoperative localization and evaluation of the tumor tissue.

ADVANCED NANOBIOMED RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases

Xinyue Chen et al.

Summary: The study quantified the micro-mechanical properties of metastatic breast tumors and their surrounding bone microenvironment using atomic force microscopy. It found that metastatic tumors have extremely low elastic modulus and viscosity, making them significantly more compliant than 2D in vitro cultured cancer cells and subcutaneous tumor explants. These findings demonstrate the utility of atomic force microscopy in studying complex tissues and provide new insights into the mechanical properties of cancer metastases in bone.

NANOSCALE (2021)

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Article Nanoscience & Nanotechnology

Quantitative Nanomechanical Mapping of Polyolefin Elastomer at Nanoscale with Atomic Force Microscopy

Shuting Zhang et al.

Summary: This study utilized advanced nanomechanical mapping techniques to investigate the time-dependent elastic moduli of LDPE samples, revealing an increase in Young's modulus with increasing acquisition frequency. Additionally, creep compliance experiments demonstrated various mechanical properties of LDPE.

NANOSCALE RESEARCH LETTERS (2021)

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Article Chemistry, Analytical

Investigation of the mechanical effects of targeted drugs on cancerous cells based on atomic force microscopy

Jiajing Zhu et al.

Summary: This study compares the mechanical effects of sorafenib tosylate and osimertinib mesylate on hepatoma carcinoma cells and lung cancerous cells using atomic force microscopy, highlighting the potential of nanomechanical properties in cancer research. The findings suggest that osimertinib mesylate is more effective in inhibiting SMMC-7721 cells, while both osimertinib mesylate and sorafenib tosylate have inhibitory effects on A549 cells, which may contribute to early-stage cancer diagnosis and treatment.

ANALYTICAL METHODS (2021)

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Article Chemistry, Multidisciplinary

Stiffening of DU145 prostate cancer cells driven by actin filaments - microtubule crosstalk conferring resistance to microtubule-targeting drugs

Andrzej Kubiak et al.

Summary: The study demonstrates that anticancer microtubule targeting drugs can induce cell stiffening by directly perturbing the structural organization of microtubules. While changes in cellular rigidity are typically attributed to remodeling of actin filaments in the cytoskeleton, it is also shown that cell stiffening can be driven by crosstalk between actin filaments and microtubules in MTD-treated cells. These findings improve the interpretation of biomechanical data obtained for living cells in studies of various physiological and pathological processes.

NANOSCALE (2021)

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Article Chemistry, Multidisciplinary

Revealing the elasticity of an individual aortic fiber during ageing at nanoscale by in situ atomic force microscopy

Alexandre Berquand et al.

Summary: Arterial stiffness is a complex process that significantly contributes to cardiovascular diseases, mainly associated with changes in elastin and collagen content. With aging, the relative Young's moduli of elastic fibers increase significantly. Techniques such as atomic force microscopy offer a new view on the stiffness process, providing insights into fiber changes and elasticity.

NANOSCALE (2021)

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Article Critical Care Medicine

Spinal Cord Injury Results in Chronic Mechanical Stiffening

John G. Cooper et al.

JOURNAL OF NEUROTRAUMA (2020)

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Article Physics, Applied

Density and function of actin-microdomains in healthy and NF1 deficient osteoclasts revealed by the combined use of atomic force and stimulated emission depletion microscopy

Takahiro Deguchi et al.

JOURNAL OF PHYSICS D-APPLIED PHYSICS (2020)

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Article Biochemistry & Molecular Biology

Changes in spinal cord stiffness in the course of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis

G. Pyka-Fosciak et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Article Engineering, Biomedical

Multi-scale mechanical investigation of articular cartilage suffered progressive pseudorheumatoid dysplasia

L. J. Lin et al.

CLINICAL BIOMECHANICS (2020)

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Article Automation & Control Systems

Scan Rate Adaptation for AFM Imaging Based on Performance Metric Optimization

Kaixiang Wang et al.

IEEE-ASME TRANSACTIONS ON MECHATRONICS (2020)

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Article Neurosciences

Statin-mediated cholesterol depletion exerts coordinated effects on the alterations in rat vascular smooth muscle cell biomechanics and migration

Hanna J. Sanyour et al.

JOURNAL OF PHYSIOLOGY-LONDON (2020)

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Review Clinical Neurology

Interpretation of risk loci from genome-wide association studies of Alzheimer's disease

Shea J. Andrews et al.

LANCET NEUROLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Reduced stiffness and augmented traction force in type 2 diabetic coronary microvascular smooth muscle

Patricia E. McCallinhart et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Metformin attenuates adhesion between cancer and endothelial cells in chronic hyperglycemia by recovery of the endothelial glycocalyx barrier

Marta Targosz-Korecka et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2020)

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Article Multidisciplinary Sciences

Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress

Bryant L. Doss et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Chemistry, Analytical

Effect of AFM Nanoindentation Loading Rate on the Characterization of Mechanical Properties of Vascular Endothelial Cell

Lei Wang et al.

MICROMACHINES (2020)

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Article Materials Science, Multidisciplinary

Modeling and simulation of three-dimensional manipulation of viscoelastic folded biological particles considering the nonlinear model of the cell by AFM

Moharam Habibnejad Korayem et al.

MECHANICS OF MATERIALS (2020)

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Article Chemistry, Physical

Cortical cell stiffness is independent of substrate mechanics

Johannes Rheinlaender et al.

NATURE MATERIALS (2020)

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Article Computer Science, Interdisciplinary Applications

Numerical simulation of deformed red blood cell by utilizing neural network approach and finite element analysis

Ying Wang et al.

COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING (2020)

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Article Engineering, Biomedical

Moderate substrate stiffness induces vascular smooth muscle cell differentiation through cellular morphological and tensional changes

Kazuaki Nagayama et al.

BIO-MEDICAL MATERIALS AND ENGINEERING (2020)

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Article Biochemistry & Molecular Biology

Alteration of Young's modulus in mesenchymal stromal cells during osteogenesis measured by atomic force microscopy

Meng-Hua Yen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Biochemical Research Methods

The promise of single-cell mechanophenotyping for clinical applications

Molly Kozminsky et al.

BIOMICROFLUIDICS (2020)

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Article Cell Biology

Recombinant Human Soluble Thrombomodulin Suppresses Monocyte Adhesion by Reducing Lipopolysaccharide-Induced Endothelial Cellular Stiffening

Takayuki Okamoto et al.

CELLS (2020)

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Review Biochemical Research Methods

Application of atomic force microscope in diagnosis of single cancer cells

Zhengcheng Lu et al.

BIOMICROFLUIDICS (2020)

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Article Clinical Neurology

Mechanical properties of human glioma

Abraham Tsitlakidis et al.

NEUROLOGICAL RESEARCH (2020)

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Article Biophysics

A bioinspired mucoadhesive restores lubrication of degraded cartilage through reestablishment of lamina splendens

Hongping Wan et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Chemistry, Multidisciplinary

Bottom Effect in Atomic Force Microscopy Nanomechanics

Stefano Chiodini et al.

SMALL (2020)

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Article Nanoscience & Nanotechnology

Nanomechanics and Histopathology as Diagnostic Tools to Characterize Freshly Removed Human Brain Tumors

Mateusz Ciesluk et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Engineering, Biomedical

Macroscopic and microscopic analysis of the mechanical properties and adhesion force of cells using a single cell tensile test and atomic force microscopy: Remarkable differences in cell types

Kazuaki Nagayama et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2020)

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Article Materials Science, Biomaterials

Tissue Rheology as a Possible Complementary Procedure to Advance Histological Diagnosis of Colon Cancer

Piotr Deptula et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Biotechnology & Applied Microbiology

Searching for the Mechanical Fingerprint of Pre-diabetes in T1DM: A Case Report Study

Flavio Di Giacinto et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Characterizing liver sinusoidal endothelial cell fenestrae on soft substrates upon AFM imaging and deep learning

Peiwen Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2020)

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Article Multidisciplinary Sciences

Elucidating nanoscale mechanical properties of diabetic human adipose tissue using atomic force microscopy

J. K. Wenderott et al.

SCIENTIFIC REPORTS (2020)

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Article Biophysics

Stabilization of liposomes with silicone layer improves their elastomechanical properties while not compromising biological features

Alicja Karabasz et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Review Oncology

Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint

Nese Karadag Soylu

JOURNAL OF GASTROINTESTINAL CANCER (2020)

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Article Chemistry, Multidisciplinary

Fast automated processing of AFM PeakForce curves to evaluate spatially resolved Young modulus and stiffness of turgescent cells

Marc Offroy et al.

RSC ADVANCES (2020)

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Article Nanoscience & Nanotechnology

Mechanobiology Analysis of Manifold Live Cells in Vitro with Atomic Force Acoustic Microscopy

Jiajing Zhu et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Morphological changes induced in erythrocyte by amyloid beta peptide and glucose depletion: A combined atomic force microscopy and biochemical study

Cristiana Carelli-Alinovi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2019)

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Article Cardiac & Cardiovascular Systems

Mechanical Characterization of the Lamellar Structure of Human Abdominal Aorta in the Development of Atherosclerosis: An Atomic Force Microscopy Study

Alireza Rezvani-Sharif et al.

CARDIOVASCULAR ENGINEERING AND TECHNOLOGY (2019)

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Article Biophysics

Dynamic effect of beta-amyloid 42 on cell mechanics

Qi Gao et al.

JOURNAL OF BIOMECHANICS (2019)

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Article Engineering, Biomedical

Modulating cancer cell mechanics and actin cytoskeleton structure by chemical and mechanical stimulations

Shohreh Azadi et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2019)

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Article Nanoscience & Nanotechnology

Combined Raman- and AFM-based detection of biochemical and nanomechanical features of endothelial dysfunction in aorta isolated from ApoE/LDLR-/- mice

Martina Maase et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Multidisciplinary Sciences

Automated multi-sample acquisition and analysis using atomic force microscopy for biomedical applications

Antoine Dujardin et al.

PLOS ONE (2019)

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Article Multidisciplinary Sciences

Acute and chronic demyelinated CNS lesions exhibit opposite elastic properties

Mateusz M. Urbanski et al.

SCIENTIFIC REPORTS (2019)

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Article Biochemistry & Molecular Biology

Alterations to plasma membrane lipid contents affect the biophysical properties of erythrocytes from individuals with hypertension

Ivette Martinez-Vieyra et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2019)

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Review Biochemistry & Molecular Biology

Atomic force microscopy-based cancer diagnosis by detecting cancer-specific biomolecules and cells

Taeyun Kwon et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

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Article Microscopy

Examination of Alzheimer's disease by a combination of electrostatic force and mechanical measurement

W. Zhao et al.

JOURNAL OF MICROSCOPY (2019)

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Article Biochemistry & Molecular Biology

Morphological and mechanical stability of bladder cancer cells in response to substrate rigidity

Malgorzata Lekka et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2019)

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Article Engineering, Biomedical

Superparamagnetic iron oxide nanoparticles of curcumin enhance gemcitabine therapeutic response in pancreatic cancer

Sheema Khan et al.

BIOMATERIALS (2019)

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Article Biotechnology & Applied Microbiology

Advances in Raman imaging combined with AFM and fluorescence microscopy are beneficial for oncology and cancer research

Halina Abramczyk et al.

NANOMEDICINE (2019)

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Article Chemistry, Physical

Cellular nanoscale stiffness patterns governed by intracellular forces

Nicola Mandriota et al.

NATURE MATERIALS (2019)

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Article Engineering, Mechanical

Robustness of attractors in tapping mode atomic force microscopy

Abhilash Chandrashekar et al.

NONLINEAR DYNAMICS (2019)

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Article Polymer Science

Analytical methods to derive the elastic modulus of soft and adhesive materials from atomic force microcopy force measurements

So Fujinami et al.

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS (2019)

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Article Engineering, Biomedical

Matrix stiffness regulates the interactions between endothelial cells and monocytes

Weicong Chen et al.

BIOMATERIALS (2019)

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Article Materials Science, Multidisciplinary

Effect of machine stiffness on interpreting contact force-indentation depth curves in adhesive elastic contact experiments

Weilin Deng et al.

JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS (2019)

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Article Multidisciplinary Sciences

Microtubule disruption changes endothelial cell mechanics and adhesion

Andreas Weber et al.

SCIENTIFIC REPORTS (2019)

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Review Biophysics

Non-invasive electromechanical cell-based biosensors for improved investigation of 3D cardiac models

Guido Caluori et al.

BIOSENSORS & BIOELECTRONICS (2019)

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Article Cardiac & Cardiovascular Systems

Membrane cholesterol and substrate stiffness co-ordinate to induce the remodelling of the cytoskeleton and the alteration in the biomechanics of vascular smooth muscle cells

Hanna J. Sanyour et al.

CARDIOVASCULAR RESEARCH (2019)

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Review Chemistry, Multidisciplinary

Atomic Force Microscopy Meets Biophysics, Bioengineering, Chemistry, and Materials Science

Jose L. Toca-Herrera

CHEMSUSCHEM (2019)

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Review Cardiac & Cardiovascular Systems

Immunity and Inflammation in Atherosclerosis

Dennis Wolf et al.

CIRCULATION RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells

Tanmay Kulkarni et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2019)

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Article Biophysics

Effects of blocking integrin β1 and N-cadherin cellular interactions on mechanical properties of vascular smooth muscle cells

Aesha Desai et al.

JOURNAL OF BIOMECHANICS (2019)

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Article Chemistry, Multidisciplinary

Biomechanical Heterogeneity of Living Cells: Comparison between Atomic Force Microscopy and Finite Element Simulation

Guanlin Tang et al.

LANGMUIR (2019)

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Article Microscopy

Finite element modeling of living cells for AFM indentation-based biomechanical characterization

Yi Liu et al.

MICRON (2019)

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Review Chemistry, Multidisciplinary

Mechanical contribution of vascular smooth muscle cells in the tunica media of artery

Hozhabr Mozafari et al.

NANOTECHNOLOGY REVIEWS (2019)

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Article Cell Biology

The effect of cytokines produced by human adipose tissue on monocyte adhesion to the endothelium

Sona Cejkova et al.

CELL ADHESION & MIGRATION (2019)

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Article Physics, Condensed Matter

Efficient Spatial Sampling for AFM-Based Cancer Diagnostics: A Comparison between Neural Networks and Conventional Data Analysis

Gabriele Ciasca et al.

CONDENSED MATTER (2019)

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Article Chemistry, Physical

Adaptability of single melanoma cells to surfaces with distinct hydrophobicity and roughness

Szymon Prauzner-Bechcicki et al.

APPLIED SURFACE SCIENCE (2018)

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Article Physics, Applied

A simple way to higher speed atomic force microscopy by retrofitting with a novel high-speed flexure-guided scanner

Bernard Ouma Alunda et al.

JAPANESE JOURNAL OF APPLIED PHYSICS (2018)

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Review Microscopy

Morphological changes in erythrocytes of people with type 2 diabetes mellitus evaluated with atomic force microscopy: A brief review

Alejandra Loyola-Leyva et al.

MICRON (2018)

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Review Cell Biology

Novel insights into cardiomyocytes provided by atomic force microscopy

Daniele Borin et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

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Article Chemistry, Multidisciplinary

The Insertion Mechanism of a Living Cell Determined by the Stress Segmentation Effect of the Cell Membrane during the Tip-Cell Interaction

Na Fan et al.

SMALL (2018)

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Article Clinical Neurology

Alzheimer's Disease Mutant Mice Exhibit Reduced Brain Tissue Stiffness Compared to Wild-type Mice in both Normoxia and following Intermittent Hypoxia Mimicking Sleep Apnea

Maria Jose Menal et al.

FRONTIERS IN NEUROLOGY (2018)

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Article Multidisciplinary Sciences

Noninvasive diagnostic imaging using machine-learning analysis of nanoresolution images of cell surfaces: Detection of bladder cancer

I. Sokolov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Environmental Sciences

Impact of Diabetes Mellitus on Human Erythrocytes: Atomic Force Microscopy and Spectral Investigations

Mohamad S. AlSalhi et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

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Review Biotechnology & Applied Microbiology

Application of atomic force microscopy in cancer research

Xiangying Deng et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Review Chemistry, Analytical

Nanoindentation of Soft Biological Materials

Long Qian et al.

MICROMACHINES (2018)

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Review Physiology

Effects of shear stress on endothelial cells: go with the flow

D. A. Chistiakov et al.

ACTA PHYSIOLOGICA (2017)

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Article Computer Science, Interdisciplinary Applications

A novel approach for extracting viscoelastic parameters of living cells through combination of inverse finite element simulation and Atomic Force Microscopy

Fanan Wei et al.

COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING (2017)

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Review Anatomy & Morphology

A beginner's guide to atomic force microscopy probing for cell mechanics

Nuria Gavara

MICROSCOPY RESEARCH AND TECHNIQUE (2017)

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Review Biochemical Research Methods

Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review

Mi Li et al.

IEEE TRANSACTIONS ON NANOBIOSCIENCE (2017)

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Article Biochemistry & Molecular Biology

A three-dimensional in vitro model to demonstrate the haptotactic effect of monocyte chemoattractant protein-1 on atherosclerosis-associated monocyte migration

Neda Ghousifam et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Review Biochemistry & Molecular Biology

New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis

Meng-Yu Wu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Chemistry, Multidisciplinary

Essential arterial hypertension patients present higher cell adhesion forces, contributing to fibrinogen-dependent cardiovascular risk

Ana F. Guedes et al.

NANOSCALE (2017)

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Article Multidisciplinary Sciences

The soft mechanical signature of glial scars in the central nervous system

Emad Moeendarbary et al.

NATURE COMMUNICATIONS (2017)

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Review Oncology

Tissue Force Programs Cell Fate and Tumor Aggression

Jason J. Northey et al.

CANCER DISCOVERY (2017)

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Article Multidisciplinary Sciences

On the determination of elastic moduli of cells by AFM based indentation

Yue Ding et al.

SCIENTIFIC REPORTS (2017)

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Article Physics, Applied

A fully-automated neural network analysis of AFM force-distance curves for cancer tissue diagnosis

Eleonora Minelli et al.

APPLIED PHYSICS LETTERS (2017)

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Article Engineering, Biomedical

Mechanical phenotyping of cells and extracellular matrix as grade and stage markers of lung tumor tissues

Valeria Panzetta et al.

ACTA BIOMATERIALIA (2017)

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Article Biophysics

Cholesterol Regulates Monocyte Rolling through CD44 Distribution

Amit K. Saha et al.

BIOPHYSICAL JOURNAL (2017)

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Article Hematology

Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1

Olivier Herbin et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Study on the influence of oxidative stress on the fibrillization of fibrinogen

Lei Wang et al.

BIOCHEMICAL JOURNAL (2016)

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Review Cell Biology

Any value in a specialist review of liver biopsies? Conclusions of a 4-year review

Anna L. Paterson et al.

HISTOPATHOLOGY (2016)

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Article Materials Science, Multidisciplinary

Atomic Force Microscopy Study of Atherosclerosis Progression in Arterial Walls

Peter S. Timashev et al.

MICROSCOPY AND MICROANALYSIS (2016)

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Article Cell Biology

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression

Yekaterina A. Miroshnikova et al.

NATURE CELL BIOLOGY (2016)

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Article Nanoscience & Nanotechnology

Atomic force microscopy as a tool to evaluate the risk of cardiovascular diseases in patients

Ana Filipa Guedes et al.

NATURE NANOTECHNOLOGY (2016)

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Article Multidisciplinary Sciences

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Bennett G. Childs et al.

SCIENCE (2016)

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Article Materials Science, Biomaterials

Discrimination Between Normal and Cancerous Cells Using AFM

Malgorzata Lekka

BIONANOSCIENCE (2016)

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Review Clinical Neurology

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

Heather M. Snyder et al.

ALZHEIMERS & DEMENTIA (2015)

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Review Engineering, Biomedical

The Mechanobiology of Aging

Jude M. Phillip et al.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 17 (2015)

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Review Biochemistry & Molecular Biology

The (dys)functional extracellular matrix

Benjamin R. Freedman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

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Meeting Abstract Biophysics

Cortical Actin Tension, Elastic Modulus and Cytosolic Pressure in Fibroblasts Determined using Atomic Force Microscopy

Alexander X. Cartagena-Rivera et al.

BIOPHYSICAL JOURNAL (2015)

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Review Cardiac & Cardiovascular Systems

Monocyte trafficking across the vessel wall

Teresa Gerhardt et al.

CARDIOVASCULAR RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Tumor mechanics and metabolic dysfunction

Jason C. Tung et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

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Article Biochemistry & Molecular Biology

Tumor Necrosis Factor Related Apoptosis Inducing Ligand (Trail) in Endothelial Response to Biomechanical and Biochemical Stresses in Arteries

F. D'Auria et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2015)

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Review Endocrinology & Metabolism

Targeting neutrophils in ischemic stroke: translational insights from experimental studies

Glen C. Jickling et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

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Review Medicine, General & Internal

Inflammation and plaque vulnerability

G. K. Hansson et al.

JOURNAL OF INTERNAL MEDICINE (2015)

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Article Engineering, Biomedical

PDMS substrate stiffness affects the morphology and growth profiles of cancerous prostate and melanoma cells

Szymon Prauzner-Bechcicki et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2015)

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Article Biochemistry & Molecular Biology

EphrinB2/EphA4-mediated activation of endothelial cells increases monocyte adhesion

David M. Poitz et al.

MOLECULAR IMMUNOLOGY (2015)

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Review Cell & Tissue Engineering

Cells and stimuli in small-caliber blood vessel tissue engineering

Claudia Tresoldi et al.

REGENERATIVE MEDICINE (2015)

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Article Instruments & Instrumentation

Nanomechanical and topographical imaging of living cells by atomic force microscopy with colloidal probes

Luca Puricelli et al.

REVIEW OF SCIENTIFIC INSTRUMENTS (2015)

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Review Biotechnology & Applied Microbiology

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

Ruchi Malik et al.

TRENDS IN BIOTECHNOLOGY (2015)

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Article Materials Science, Multidisciplinary

Mechanical behavior of osteoporotic bone at sub-lamellar length scales

Ines Jimenez-Palomar et al.

FRONTIERS IN MATERIALS (2015)

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Article Biophysics

Nano-characterization of two closely related melanoma cell lines with different metastatic potential

Justyna Gostek et al.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2015)

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Review Cell Biology

Atomic force microscopy-based force measurements on animal cells and tissues

Helene O. B. Gautier et al.

BIOPHYSICAL METHODS IN CELL BIOLOGY (2015)

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Article Hematology

Shear Stress-Initiated Signaling and Its Regulation of Endothelial Function

Jing Zhou et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

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Inflammation and Atherosclerosis: A Review of the Role of Interleukin-6 in the Development of Atherosclerosis and the Potential for Targeted Drug Therapy

Joshua Hartman et al.

CARDIOLOGY IN REVIEW (2014)

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Article Geriatrics & Gerontology

Nano-structural, compositional and micro-architectural signs of cortical bone fragility at the superolateral femoral neck in elderly hip fracture patients vs. healthy aged controls

Petar Milovanovic et al.

EXPERIMENTAL GERONTOLOGY (2014)

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Article Engineering, Biomedical

A micromechanical procedure for viscoelastic characterization of the axons and ECM of the brainstem

Samad Javid et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2014)

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Article Engineering, Multidisciplinary

The determination of the spring constant of T-shaped cantilevers using calibration structures

Andrzej Sikora et al.

MEASUREMENT SCIENCE AND TECHNOLOGY (2014)

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Article Instruments & Instrumentation

Effect of cantilever geometry on the optical lever sensitivities and thermal noise method of the atomic force microscope

John E. Sader et al.

REVIEW OF SCIENTIFIC INSTRUMENTS (2014)

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Review Microscopy

Nano-palpation AFM and its quantitative mechanical property mapping

Ken Nakajima et al.

MICROSCOPY (2014)

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Article Biochemistry & Molecular Biology

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

Daniel E. Conway et al.

CURRENT BIOLOGY (2013)

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Article Nanoscience & Nanotechnology

Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli

Fernando Teran Arce et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2013)

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Article Multidisciplinary Sciences

Elongated Membrane Tethers, Individually Anchored by High Affinity α4β1/VCAM-1 Complexes, Are the Quantal Units of Monocyte Arrests

Calvin Chu et al.

PLOS ONE (2013)

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Review Chemistry, Multidisciplinary

Opportunities in High-Speed Atomic Force Microscopy

Benjamin P. Brown et al.

SMALL (2013)

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Article Biochemistry & Molecular Biology

Cancer cell detection in tissue sections using AFM

Malgorzata Lekka et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2012)

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Article Nanoscience & Nanotechnology

The nanomechanical signature of breast cancer

Marija Plodinec et al.

NATURE NANOTECHNOLOGY (2012)

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Article Engineering, Biomedical

Nanostructure and mineral composition of trabecular bone in the lateral femoral neck: Implications for bone fragility in elderly women

Petar Milovanovic et al.

ACTA BIOMATERIALIA (2011)

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Review Materials Science, Multidisciplinary

Linear and Nonlinear Rheology of Living Cells

Philip Kollmannsberger et al.

ANNUAL REVIEW OF MATERIALS RESEARCH, VOL 41 (2011)

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Article Biophysics

Effects of Gel Thickness on Microscopic Indentation Measurements of Gel Modulus

Rong Long et al.

BIOPHYSICAL JOURNAL (2011)

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Article Multidisciplinary Sciences

Variations on Fibrinogen-Erythrocyte Interactions during Cell Aging

Filomena A. Carvalho et al.

PLOS ONE (2011)

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Review Mathematics, Applied

A Brief Review of Elasticity and Viscoelasticity for Solids

Harvey Thomas Banks et al.

ADVANCES IN APPLIED MATHEMATICS AND MECHANICS (2011)

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Article Biophysics

Spherical indentation of soft matter beyond the Hertzian regime: numerical and experimental validation of hyperelastic models

David C. Lin et al.

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2009)

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Review Oncology

Pitfalls and procedures in the histopathological diagnosis of oral and oropharyngeal squamous cell carcinoma and a review of the role of pathology in prognosis

Julia Anne Woolgar et al.

ORAL ONCOLOGY (2009)

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Imaging aspects of cardiovascular disease at the cell and molecular level

Douglas J. Taatjes et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2008)

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Aspects of scanning force microscope probes and their effects on dimensional measurement

Andrew Yacoot et al.

JOURNAL OF PHYSICS D-APPLIED PHYSICS (2008)

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Article Microscopy

Real-time observations of mechanical stimulus-induced enhancements of mechanical properties in osteoblast cells

Xu Zhang et al.

ULTRAMICROSCOPY (2008)

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Review Physics, Multidisciplinary

Atomic force microscopy and spectroscopy

Yongho Seo et al.

REPORTS ON PROGRESS IN PHYSICS (2008)

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Article Nanoscience & Nanotechnology

An atomic force microscope tip designed to measure time-varying nanomechanical forces

Ozgur Sahin et al.

NATURE NANOTECHNOLOGY (2007)

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Article Biophysics

A thin-layer model for viscoelastic, stress-relaxation testing of cells using atomic force microscopy: Do cell properties reflect metastatic potential?

Eric M. Darling et al.

BIOPHYSICAL JOURNAL (2007)

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Review Biophysics

Atomic force microscopy of microbial cells:: Application to nanomechanical properties, surface forces and molecular recognition forces

Fabien Gaboriaud et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2007)

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Article Microscopy

Calibration of the spring constant of AFM cantilever

G. Y. Jing et al.

JOURNAL OF ELECTRON MICROSCOPY (2007)

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Review Microscopy

Atomic force microscopy probing of cell elasticity

Tatyana G. Kuznetsova et al.

MICRON (2007)

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Article Instruments & Instrumentation

Precision and accuracy of thermal calibration of atomic force microscopy cantilevers

G. A. Matei et al.

REVIEW OF SCIENTIFIC INSTRUMENTS (2006)

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Article Cardiac & Cardiovascular Systems

Mechanical properties of the interaction between fibronectin and α5β1-integrin on vascular smooth muscle cells studied using atomic force microscopy

Z Sun et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)

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Review Chemistry, Physical

Force measurements with the atomic force microscope: Technique, interpretation and applications

HJ Butt et al.

SURFACE SCIENCE REPORTS (2005)

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Article Chemistry, Physical

Elasticity of polyelectrolyte multilayer microcapsules

VV Lulevich et al.

JOURNAL OF CHEMICAL PHYSICS (2004)

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Measurement of hardness and elastic modulus by instrumented indentation: Advances in understanding and refinements to methodology

WC Oliver et al.

JOURNAL OF MATERIALS RESEARCH (2004)

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Review Chemistry, Physical

Cell and molecular mechanics of biological materials

G Bao et al.

NATURE MATERIALS (2003)

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Article Biophysics

Determination of elastic moduli of thin layers of soft material using the atomic force microscope

EK Dimitriadis et al.

BIOPHYSICAL JOURNAL (2002)

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Probing the machinery of intracellular trafficking with the atomic force microscope

S Kumar et al.

TRAFFIC (2001)

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Article Dentistry, Oral Surgery & Medicine

Mechanical properties of human dental enamel on the nanometre scale

S Habelitz et al.

ARCHIVES OF ORAL BIOLOGY (2001)

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