Allicin extracted from Allium sativum shows potent anti-cancer and antioxidant properties in zebrafish

Garlic (Allium sativum) is an important flavouring component in Indian cuisine. Allicin, a sulphur containing compound, is the most abundant component of garlic and has been widely studied for its antimicrobial and antioxidant properties. It is also known to play a role in the regulation of blood pressure and cholesterol levels. Despite the known health benefits associated with allicin, systematic studies on its anti-cancer properties using animal models are very limited. This study aimed to develop a simple method for the extraction of allicin from fresh garlic, study the stability of the extracted compound at various temperatures, and evaluate the antioxidant, anti-proliferative, pro-apoptotic and anti-angiogenic properties in zebrafish. A five-month stability study indicated that allicin remains significantly stable at temperatures 4 degrees C and below but shows extensive degradation if stored at room temperature. The in vivo studies in zebrafish using a combination of mutants and transgenic lines demonstrated the antioxidant, anti-proliferative, apoptotic and anti-angiogenic properties of allicin. The study highlights the importance of natural bioactive compounds as potential anti-cancer agents that can be studied further.

Automated summary

Garlic is an important ingredient in Indian cuisine and its most abundant component, allicin, has been studied for its antimicrobial and antioxidant properties. This study aimed to develop a simple method for allicin extraction from fresh garlic and evaluate its properties in zebrafish, including antioxidant, anti-proliferative, pro-apoptotic, and anti-angiogenic effects.