☆ 4.6 Article

Immune microenvironment profiling of normal appearing colorectal mucosa biopsied over repeat patient visits reproducibly separates lynch syndrome patients based on their history of colon cancer

FRONTIERS IN ONCOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Multidisciplinary Sciences

rxCOV is a quantitative metric for assessing immunoassay analyte fidelity

Rhonda. M. M. Brand et al.

Summary: Immunoassay based bioanalytical measurements are widely used in biomedical research and clinical applications. However, there is currently no objective metric to assess the accuracy of these measurements. This study introduces a fidelity metric called ratio of cross-coefficient-of-variation (rxCOV) to objectively evaluate the measurement quality of immunoassay analytes in comparing different sample groups or experimental conditions. The feasibility and applicability of rxCOV are demonstrated using simulated and experimental data, showing its independence from statistical significance and ability to identify meaningful differences. Its importance in increasing signal to noise ratio and its potential applications are also discussed. The adoption of rxCOV as a simple and easy-to-use fidelity metric for robust and reproducible biomedical research is anticipated.

SCIENTIFIC REPORTS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

The reactome pathway knowledgebase 2022

Marc Gillespie et al.

Summary: The Reactome Knowledgebase, a core resource of Elixir, provides manually curated molecular details of human biological processes, serving as a digital archive and tool for discovering functional relationships. Recent work has expanded annotations of signaling processes, drugs targeting them, infections by coronaviruses, and better analysis tools for high-throughput data and placement of unstudied proteins.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection

Article Gastroenterology & Hepatology

The Different Immune Profiles of Normal Colonic Mucosa in Cancer-Free Lynch Syndrome Carriers and Lynch Syndrome Colorectal Cancer Patients

Lena Bohaumilitzky et al.

Summary: The immune infiltrate in tumor-distant normal colorectal mucosa from individuals with Lynch syndrome (LS) was assessed. It was found that LS carriers show elevated mucosal T-cell infiltration even in the absence of cancer, and this immune profile may impact tumor risk in LS carriers.

GASTROENTEROLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The Gene Ontology resource: enriching a GOld mine

Seth Carbon et al.

Summary: The Gene Ontology Consortium has made advancements in the last two years, such as improving the GO-CAM annotation framework, increasing the number of annotations and annotated gene products, and reviewing older annotations for consistency.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Article Biochemical Research Methods

Systematic investigation of cytokine signaling activity at the tissue and single-cell levels

Peng Jiang et al.

Summary: CytoSig is an interactive database and model for predicting cytokine signaling activity at bulk and single-cell levels. By analyzing 20,591 transcriptome profiles, it enables reliable prediction of signaling activities in different cell populations and reveals previously unknown roles of many cytokines.

NATURE METHODS (2021)

Add to Collection

Review Oncology

Immunology of Lynch Syndrome

Danielle M. Pastor et al.

Summary: The review provides a comprehensive assessment of the immunologic aspects of Lynch syndrome pathogenesis, focusing on the immunogenic properties of Lynch syndrome polyps and associated cancers, as well as potential immune interventions. The rich immune microenvironment of Lynch syndrome lesions offers opportunities for immune-mediating agents to enhance host immune responses and reduce immunosuppressive entities, which can be utilized in prevention and treatment trials for patients with Lynch syndrome polyps and associated cancers.

CURRENT ONCOLOGY REPORTS (2021)

Add to Collection

Review Oncology

Immune Activation in Mismatch Repair-Deficient Carcinogenesis: More Than Just Mutational Rate

Jason A. Willis et al.

CLINICAL CANCER RESEARCH (2020)

Add to Collection

Article Oncology

Detection of DNA mismatch repair deficient crypts in random colonoscopic biopsies identifies Lynch syndrome patients

Randall E. Brand et al.

FAMILIAL CANCER (2020)

Add to Collection

Review Medicine, General & Internal

Implications of Hereditary Origin on the Immune Phenotype of Mismatch Repair-Deficient Cancers: Systematic Literature Review

Lena Bohaumilitzky et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Add to Collection

Article Multidisciplinary Sciences

Plasma cytokine levels and the presence of colorectal cancer

Masaki Yamaguchi et al.

PLOS ONE (2019)

Add to Collection

Article Immunology

Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment

Christina Eftychi et al.

IMMUNITY (2019)

Add to Collection

Review Medicine, General & Internal

Hereditary Cancer Syndromesd-A Primer on Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes

N. Jewel Samadder et al.

MAYO CLINIC PROCEEDINGS (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor Microenvironment

Yoshiro Itatani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Review Immunology

The role of interleukin-1 in general pathology

Naoe Kaneko et al.

INFLAMMATION AND REGENERATION (2019)

Add to Collection

Article Immunology

Ranpirnase Reduces HIV-1 Infection and Associated Inflammatory Changes in a Human Colorectal Explant Model

Rhonda M. Brand et al.

AIDS RESEARCH AND HUMAN RETROVIRUSES (2018)

Add to Collection

Article Pathology

DNA mismatch repair protein deficient non-neoplastic colonic crypts: a novel indicator of Lynch syndrome

Rish K. Pai et al.

MODERN PATHOLOGY (2018)

Add to Collection

Review Immunology

Tuning the Cytokine Responses: An Update on interleukin (IL)-4 and IL-13 Receptor Complexes

Ilkka S. Junttila

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Biochemical Research Methods

Immunological responsiveness of intestinal tissue explants and mucosal mononuclear cells to ex vivo stimulation

Rhonda M. Brand et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2018)

Add to Collection

Editorial Material Gastroenterology & Hepatology

Interleukin 12/interleukin 23 pathway: Biological basis and therapeutic effect in patients with Crohn's disease

Ioanna Aggeletopoulou et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

Add to Collection

Article Gastroenterology & Hepatology

No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies

Christoph Engel et al.

GASTROENTEROLOGY (2018)

Add to Collection

Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

Add to Collection

Article Immunology

NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1

Mirza Saqib Baig et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Add to Collection

Article Statistics & Probability

Regularization Paths for Cox's Proportional Hazards Model via Coordinate Descent

Noah Simon et al.

Journal of Statistical Software (2015)

Add to Collection

Article Multidisciplinary Sciences

Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome - Molecular Alterations and Association with Clinical Parameters

Laura Staffa et al.

PLOS ONE (2015)

Add to Collection

Article Oncology

Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma

T. Kantola et al.

BRITISH JOURNAL OF CANCER (2012)

Add to Collection

Article Oncology

Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study

Matthias Kloor et al.

LANCET ONCOLOGY (2012)

Add to Collection

Article Computer Science, Interdisciplinary Applications

Regularization Paths for Generalized Linear Models via Coordinate Descent

Jerome Friedman et al.

JOURNAL OF STATISTICAL SOFTWARE (2010)

Add to Collection

Article Medicine, General & Internal

NF-κB in inflammatory bowel disease

I. Atreya et al.

JOURNAL OF INTERNAL MEDICINE (2008)

Add to Collection

Article Statistics & Probability

Regularization and variable selection via the elastic net

H Zou et al.

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY (2005)

Add to Collection

Review Immunology

Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle

G Kolios et al.

IMMUNOLOGY (2004)

Add to Collection

Article Computer Science, Artificial Intelligence

Random forests

L Breiman

MACHINE LEARNING (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.