4.7 Article

Lead-oriented synthesis of epigenetic relevant scaffolds

Journal

CHEMICAL COMMUNICATIONS
Volume 59, Issue 98, Pages 14555-14558

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d3cc04317g

Keywords

-

Ask authors/readers for more resources

We developed a simple and rational method to rank lead-likeness of molecules using continuous evaluation functions, which has proven to be competitive against known methods and has helped in selecting promising candidate molecules for epigenetic applications.
A simple and rational method to rank lead-likeness of molecules using continuous evaluation functions was hereby developed. This strategy proved to be competitive against known methods and finally helped in driving synthetic efforts towards candidates of interest for epigenetic applications against HDAC6, BRD4 and EZH2. We report a simple and rational method to rank lead-likeness of molecules using continuous evaluation functions.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available