Journal
PLOS GENETICS
Volume 12, Issue 2, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1005765
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Funding
- British Heart Foundation
- Cancer Research UK
- Economic and Social Research Council
- Medical Research Council
- National Institute for Health Research under UK Clinical Research Collaboration
- Wellcome Trust
- Medical Research Council Integrative Epidemiology Unit at the University of Bristol [MC UU 12013/1, MC UU 12013/6]
- MRC [MC_UU_12013/1, MC_UU_12013/6] Funding Source: UKRI
- Medical Research Council [MC_UU_12013/1, 1046634, MC_UU_12013/6, MR/K023195/1] Funding Source: researchfish
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As our understanding of genetics has improved, genome-wide association studies (GWAS) have identified numerous variants associated with lifestyle behaviours and health outcomes. However, what is sometimes overlooked is the possibility that genetic variants identified in GWAS of disease might reflect the effect of modifiable risk factors as well as direct genetic effects. We discuss this possibility with illustrative examples from tobacco and alcohol research, in which genetic variants that predict behavioural phenotypes have been seen in GWAS of diseases known to be causally related to these behaviours. This consideration has implications for the interpretation of GWAS findings.
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