Lysosome regulation of microglia in Alzheimer's disease via TFEB-vacuolar ATPase

We show that genetic disruption of TFEB- and vacuolar ATPase-mediated lysosomal signaling leads to increased tau pathology and defective microglia activation. Our findings demonstrate an essential role of the lysosome in regulating microglia activity in tauopathy and Alzheimer's disease.

Automated summary

Disruption of lysosomal signaling leads to increased tau pathology and defective microglia activation.