Journal
PLOS COMPUTATIONAL BIOLOGY
Volume 12, Issue 5, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pcbi.1004897
Keywords
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Funding
- Warwick Systems Biology DTC fellowship - UK Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council [BB/G530233/1]
- Bundesministerium fur Bildung und Forschung [01GQ1406]
- Biotechnology and Biological Sciences Research Council [1090866] Funding Source: researchfish
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Integration of synaptic currents across an extensive dendritic tree is a prerequisite for computation in the brain. Dendritic tapering away from the soma has been suggested to both equalise contributions from synapses at different locations and maximise the current transfer to the soma. To find out how this is achieved precisely, an analytical solution for the current transfer in dendrites with arbitrary taper is required. We derive here an asymptotic approximation that accurately matches results from numerical simulations. From this we then determine the diameter profile that maximises the current transfer to the soma. We find a simple quadratic form that matches diameters obtained experimentally, indicating a fundamental architectural principle of the brain that links dendritic diameters to signal transmission.
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