4.8 Article

Myeloid PFKFB3-mediated glycolysis promotes kidney fibrosis

Related references

Note: Only part of the references are listed.
Article Cell Biology

PFKFB3-Mediated Glycolysis Boosts Fibroblast Activation and Subsequent Kidney Fibrosis

Qiuhua Yang et al.

Summary: This study demonstrates the critical role of glycolytic activator PFKFB3 in driving fibroblast activation and subsequent renal fibrosis. It also highlights the promoting effect of lactate on renal fibrosis.

CELLS (2023)

Article Pharmacology & Pharmacy

Endothelial AMPKα1/PRKAA1 exacerbates inflammation in HFD-fed mice

Qiuhua Yang et al.

Summary: This study found that endothelial cell AMPKα1/PRKAA1 deficiency unexpectedly alleviated high fat diet-induced metabolic syndrome. The experimental results showed that knockdown of PRKAA1 led to reduced endothelial cell inflammation, decreased body weight and fat mass, while also improving glucose clearance and insulin sensitivity.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Article Peripheral Vascular Disease

Myeloid Piezo1 Deletion Protects Renal Fibrosis by Restraining Macrophage Infiltration and Activation

Yu He et al.

Summary: This study reveals the important role of Piezo1 in renal fibrosis, specifically in macrophages. The deletion of Piezo1 in macrophages can suppress macrophage inflammation, kidney fibrosis, and epithelial-mesenchymal transition. Targeting Piezo1 channels through genetic or pharmacological manipulations may be a promising approach for treating renal fibrosis.

HYPERTENSION (2022)

Article Medicine, General & Internal

Aerobic glycolysis imaging of epileptic foci during the inter-ictal period

Miao Zhang et al.

Summary: For patients with temporal lobe epilepsy, OGI imaging during inter-ictal period shows higher values on the same side as the epileptic focus compared to the opposite side. OGI results agree with invasive electrophysiology, providing promising insights into metabolic changes in epilepsy.

EBIOMEDICINE (2022)

Article Pharmacology & Pharmacy

Gene-dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis

Shuai Guo et al.

Summary: PFKFB3 plays a dual role in the pathogenesis of atherosclerosis. It controls the proliferation and infiltration of proinflammatory monocytes, and its expression is associated with expansion of inflammatory monocytes in patients with atherosclerotic coronary artery disease. However, homozygous loss of Pfkfb3 impairs macrophage efferocytosis and exacerbates atherosclerosis in Apoe(-/-) mice.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Article Pharmacology & Pharmacy

Suppression of myeloid PFKFB3-driven glycolysis protects mice from choroidal neovascularization

Zhiping Liu et al.

Summary: The study revealed that macrophages play a crucial role in nAMD, with their glycolytic metabolism regulated by PFKFB3 participating in the development of CNV, providing a new therapeutic strategy for treating nAMD.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Review Pharmacology & Pharmacy

Targeting glycolysis in non-small cell lung cancer: Promises and challenges

Jia-Qi Xu et al.

Summary: Metabolic disturbance, particularly of glucose metabolism, is a hallmark of tumors such as non-small cell lung cancer (NSCLC). This review focuses on research advances in glycolysis in NSCLC and systematically provides an overview of the key enzymes, biomarkers, non-coding RNAs, and signaling pathways that modulate the glycolysis process and, consequently, tumor growth and metastasis in NSCLC. Current medications, therapeutic approaches, and natural products that affect glycolysis in NSCLC are also summarized. The development of metabolic intervention that targets glycolysis, alone or in combination with current therapy, is a potential therapeutic approach in NSCLC treatment.

FRONTIERS IN PHARMACOLOGY (2022)

Review Pharmacology & Pharmacy

The significance of glycolysis in tumor progression and its relationship with the tumor microenvironment

Daoying Zhou et al.

Summary: Glycolysis plays a significant role in tumor growth and development, particularly its association with the tumor microenvironment (TME) and its impact on lactate accumulation and immunosuppression in the TME. Studying the interaction between glycolysis and TME can provide new insights for clinical treatment of tumors.

FRONTIERS IN PHARMACOLOGY (2022)

Article Medicine, General & Internal

Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis

Shihui Xu et al.

Summary: The study found that LIF is the most upregulated IL6 family member in human and mouse renal fibrotic lesions. Clinical data showed that baseline urinary levels of LIF in CKD patients can predict the risk of CKD progression to end-stage kidney disease. In mouse TIF models, inhibiting LIFR alleviated TIF, while overexpressing LIF exacerbated TIF.

EBIOMEDICINE (2022)

Review Immunology

The role of the macrophage-to-myofibroblast transition in renal fibrosis

Jia Wei et al.

Summary: This article summarizes the role and mechanisms of macrophage-to-myofibroblast transition (MMT) in renal fibrosis, which has important implications for the treatment of renal fibrosis in chronic kidney disease.

FRONTIERS IN IMMUNOLOGY (2022)

Article Immunology

Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis

Hua Liang et al.

Summary: This study explored the role of Jmjd3/IRF4 axis in renal fibrosis. The researchers found that Jmjd3 and IRF4 were highly induced in injured kidneys and played a crucial role in the activation of myeloid fibroblasts and the transition of M2 macrophages into myofibroblasts. Inhibition of Jmjd3 and IRF4 reduced fibroblast activation, M2MMT, and kidney fibrosis progression.

FRONTIERS IN IMMUNOLOGY (2022)

Article Cardiac & Cardiovascular Systems

ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease

Qian Ma et al.

Summary: This study reveals the important role of de novo purine synthesis in VSMC proliferation in arterial disease and suggests that targeting ATIC could be a promising therapeutic approach.

CIRCULATION (2022)

Article Pharmacology & Pharmacy

Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia-induced pulmonary hypertension

Lina Wang et al.

Summary: The study demonstrates that the reduced expression of glycolytic molecules in lung macrophages due to Pfkfb3 deficiency or inhibition can effectively alleviate the development of pulmonary hypertension, with lower levels of growth factors and pro-inflammatory cytokines produced by alveolar macrophages.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Cell Biology

Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic Disorders

Qiuhua Yang et al.

Summary: The deficiency of Prkaa1 in myeloid cells impacts the expression of genes involved in glucose and lipid metabolism, compromises macrophages' metabolic abilities, reduces their recruitment in various tissues, and ultimately leads to a deceleration in the development of related metabolic disorders.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Urology & Nephrology

Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation

Kensuke Sasaki et al.

Summary: Deletion of Irf4 from myeloid cells reduces renal fibrosis and activation of macrophages after severe AKI, primarily through inhibiting PI3 kinase/AKT pathway and monocyte recruitment. These findings provide new insights into the role of IRF4 in regulating kidney injury recovery.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Medicine, General & Internal

Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions

Kenichiro Miyauchi et al.

Summary: Anemia decreases blood pressure in human patients and mouse models, with renal interstitial fibroblasts functioning as central controllers of systemic oxygen delivery by producing both renin and erythropoietin. Interstitial renin expression in injured fibrotic kidneys may affect systemic blood pressure.

EBIOMEDICINE (2021)

Review Medicine, General & Internal

Glucose Metabolism in Acute Kidney Injury and Kidney Repair

Lu Wen et al.

Summary: The kidneys play a crucial role in glucose homeostasis and abnormal glucose metabolism is associated with kidney diseases such as acute kidney injury. This review discusses the regulation of glucose homeostasis in kidneys and the impact of glucose metabolism on different types of AKI. Further research on glucose metabolism in kidney injury and repair could lead to the discovery of new therapeutic targets for kidney diseases.

FRONTIERS IN MEDICINE (2021)

Review Medicine, General & Internal

Metabolic Reprogramming and Renal Fibrosis

Xiaoyu Zhu et al.

Summary: Chronic kidney disease is associated with renal fibrosis, which is influenced by metabolic abnormalities. Normal energy metabolism is crucial for maintaining kidney structure and function. Future challenges include identifying and developing new drugs that disrupt metabolic reprogramming and fibrosis progression.

FRONTIERS IN MEDICINE (2021)

Article Endocrinology & Metabolism

Disruption of endothelial Pfkfb3 ameliorates diet-induced murine insulin resistance

Qiuhua Yang et al.

Summary: The study found that increased endothelial PFKFB3 expression promotes diet-induced inflammatory responses and subsequent insulin resistance, suggesting that endothelial metabolic alteration plays an important role in the development of insulin resistance.

JOURNAL OF ENDOCRINOLOGY (2021)

Article Multidisciplinary Sciences

Decoding myofibroblast origins in human kidney fibrosis

Christoph Kuppe et al.

Summary: Using single-cell RNA sequencing, researchers profiled the transcriptomes of healthy and fibrotic human kidneys, identifying distinct subpopulations of pericytes and fibroblasts as the main sources of scar-forming myofibroblasts during kidney fibrosis. This study shed light on the cellular origins and differentiation of myofibroblasts in human kidney fibrosis, identifying potential therapeutic targets such as NKD2.

NATURE (2021)

Article Multidisciplinary Sciences

Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition

Patrick Ming-Kuen Tang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Urology & Nephrology

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease

Bryan R. Conway et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

Review Urology & Nephrology

Macrophages: versatile players in renal inflammation and fibrosis

Patrick Ming-Kuen Tang et al.

NATURE REVIEWS NEPHROLOGY (2019)

Article Urology & Nephrology

KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis

Yi Wen et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

Article Multidisciplinary Sciences

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

Yapeng Cao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Physiology

Glycolysis inhibitors suppress renal interstitial fibrosis via divergent effects on fibroblasts and tubular cells

Qingqing Wei et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)

Article Medicine, Research & Experimental

Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis

Divya Bhatia et al.

JCI INSIGHT (2019)

Article Transplantation

Macrophages in diabetic nephropathy in patients with type 2 diabetes

Celine Q. F. Klessens et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2017)

Article Urology & Nephrology

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

Ying-Ying Wang et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Editorial Material Urology & Nephrology

M1 macrophage triggered by Mincle leads to a deterioration of acute kidney injury

Tsuyoshi Inoue

KIDNEY INTERNATIONAL (2017)

Review Immunology

Metabolism Supports Macrophage Activation

P. Kent Langston et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Physiology

Inhibiting aerobic glycolysis suppresses renal interstitial fibroblast activation and renal fibrosis

Hao Ding et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)

Review Biology

Tissue macrophages: heterogeneity and functions

Siamon Gordon et al.

BMC BIOLOGY (2017)

Article Cell Biology

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis

Xiao-Ming Meng et al.

CELL DEATH & DISEASE (2016)

Article Critical Care Medicine

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

Na Xie et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Article Chemistry, Medicinal

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

Scott Boyd et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Urology & Nephrology

Origin of myofibroblasts and cellular events triggering fibrosis

Matthias Mack et al.

KIDNEY INTERNATIONAL (2015)

Review Medicine, General & Internal

Fibrosis - A Common Pathway to Organ Injury and Failure

Don C. Rockey et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Physiology

Macrophages in Kidney Injury, Inflammation, and Fibrosis

Qi Cao et al.

PHYSIOLOGY (2015)

Review Pediatrics

Macrophage-mediated injury and repair after ischemic kidney injury

Sarah C. Huen et al.

PEDIATRIC NEPHROLOGY (2015)

Article Hematology

Endothelial PFKFB3 Plays a Critical Role in Angiogenesis

Yiming Xu et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

Review Urology & Nephrology

Macrophages promote renal fibrosis through direct and indirect mechanisms

David J. Nikolic-Paterson et al.

KIDNEY INTERNATIONAL SUPPLEMENTS (2014)

Article Biochemistry & Molecular Biology

Origin and function of myofibroblasts in kidney fibrosis

Valerie S. LeBleu et al.

NATURE MEDICINE (2013)

Article Physiology

Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis

Yingjie Han et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

Article Medicine, Research & Experimental

Inhibition of matrix metalloproteinases reduces ischemia-reperfusion acute kidney injury

Shinobu Kunugi et al.

LABORATORY INVESTIGATION (2011)

Article Pathology

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

Benjamin D. Humphreys et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

Article Biochemistry & Molecular Biology

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

Elisabeth M. Zeisberg et al.

NATURE MEDICINE (2007)

Article Multidisciplinary Sciences

Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice

Sandra B. Haudek et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1

HS Lu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Pathology

Conditional ablation of macrophages halts progression of crescentic glomerulonephritis

JS Duffield et al.

AMERICAN JOURNAL OF PATHOLOGY (2005)

Article Urology & Nephrology

Interferon-γ augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism

Y Ikezumi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)

Article Biochemistry & Molecular Biology

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

HS Lu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Transplantation

Local macrophage proliferation correlates with increased renal M-CSF expression in human glomerulonephritis

NM Isbel et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2001)