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Mechanisms of Ovarian Cancer-Associated Cachexia

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JOURNAL OF CLINICAL MEDICINE (2018)

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Sarcopenia in Advanced Serous Ovarian Cancer

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INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2017)

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TNF-α and cancer cachexia: Molecular insights and clinical implications

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LIFE SCIENCES (2017)

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Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Justin L. Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Psoas muscle area is not representative of total skeletal muscle area in the assessment of sarcopenia in ovarian cancer

Iris J. G. Rutten et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2017)

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ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass

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SCIENTIFIC REPORTS (2017)

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The role of hypothalamic inflammation, the hypothalamic-pituitary-adrenal axis and serotonin in the cancer anorexia-cachexia syndrome

Klaske van Norren et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2017)

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The influence of sarcopenia on survival and surgical complications in ovarian cancer patients undergoing primary debulking surgery

I. J. G. Rutten et al.

EJSO (2017)

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Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response

Shi-Ying Cai et al.

JCI INSIGHT (2017)

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MAP3K11/GDF15 axis is a critical driver of cancer cachexia

Lorena Lerner et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2016)

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Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

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CELL (2016)

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Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity

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CELL METABOLISM (2016)

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Muscle composition measured by CT scan is a measurable predictor of overall survival in advanced ovarian cancer

Amanika Kumar et al.

GYNECOLOGIC ONCOLOGY (2016)

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Cytokine Signaling in Skeletal Muscle Wasting

Jin Zhou et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)

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Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs

Rafael Barreto et al.

ONCOTARGET (2016)

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Loss of skeletal muscle during neoadjuvant chemotherapy is related to decreased survival in ovarian cancer patients

Iris J. G. Rutten et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2016)

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Network of hypothalamic neurons that control appetite

Jong-Woo Sohn

BMB REPORTS (2015)

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Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women

Melissa M. Markofski et al.

EXPERIMENTAL GERONTOLOGY (2015)

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Role of Activin A and Myostatin in Human Cancer Cachexia

Audrey Loumaye et al.

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Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

Shihyin Tsai et al.

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Excess TGF-β mediates muscle weakness associated with bone metastases in mice

David L. Waning et al.

NATURE MEDICINE (2015)

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The regulation of muscle mass by endogenous glucocorticoids

Theodore P. Braun et al.

FRONTIERS IN PHYSIOLOGY (2015)

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Adipose tissue lipolysis and energy metabolism in early cancer cachexia in mice

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CANCER BIOLOGY & THERAPY (2015)

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Skeletal Muscle Depletion and Markers for Cancer Cachexia Are Strong Prognostic Factors in Epithelial Ovarian Cancer

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PLOS ONE (2015)

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Measurement of skeletal muscle radiation attenuation and basis of its biological variation

J. Aubrey et al.

ACTA PHYSIOLOGICA (2014)

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Molecular Mechanisms of Bone Metastasis and Associated Muscle Weakness

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CLINICAL CANCER RESEARCH (2014)

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Elevated expression of activins promotes muscle wasting and cachexia

Justin L. Chen et al.

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IL-6 Impairs Myogenic Differentiation by Downmodulation of p90RSK/eEF2 and mTOR/p70S6K Axes, without Affecting AKT Activity

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BIOMED RESEARCH INTERNATIONAL (2014)

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Cancer cachexia: understanding the molecular basis

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NATURE REVIEWS CANCER (2014)

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Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK

James P. White et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)

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The Role of Estrogens in Control of Energy Balance and Glucose Homeostasis

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Nutritional status, CT body composition measures and survival in ovarian cancer

Michelle L. Torres et al.

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Evaluating cell lines as tumour models by comparison of genomic profiles

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Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways

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Glucocorticoids increase interleukin-6-dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor

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Withaferin A Synergizes the Therapeutic Effect of Doxorubicin through ROS-Mediated Autophagy in Ovarian Cancer

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PLOS ONE (2012)

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The role of insulin resistance in the development of muscle wasting during cancer cachexia

Mary A. Honors et al.

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Gut barrier dysfunction in the ApcMin/+ mouse model of colon cancer cachexia

Melissa J. Puppa et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

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Expression Pattern of Receptor Activator of NFκB (RANK) in a Series of Primary Solid Tumors and Related Bone Metastases

Daniele Santini et al.

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Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis

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Definition and classification of cancer cachexia: an international consensus

Kenneth Fearon et al.

LANCET ONCOLOGY (2011)

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Integrated genomic analyses of ovarian carcinoma

D. Bell et al.

NATURE (2011)

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The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse

James P. White et al.

PLOS ONE (2011)

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STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

Andrea Bonetto et al.

PLOS ONE (2011)

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The advantages and limitations of cross-sectional body composition analysis

Alisdair J. MacDonald et al.

Current Opinion in Supportive and Palliative Care (2011)

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Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

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SKELETAL MUSCLE (2011)

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Benefits of Estrogen Replacement for Skeletal Muscle Mass and Function in Post-Menopausal Females: Evidence from Human and Animal Studies

Peter M. Tiidus

EURASIAN JOURNAL OF MEDICINE (2011)

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Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

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CELL (2010)

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Insulin/IGF-1 paradox of aging: Regulation via AKT/IKK/NF-κB signaling

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Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice

Michelle L. Asp et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

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The Role of Inflammation in Cholestasis: Clinical and Basic Aspects

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SEMINARS IN LIVER DISEASE (2010)

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The genesis and evolution of high-grade serous ovarian cancer

David D. L. Bowtell

NATURE REVIEWS CANCER (2010)

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Interleukin-1 stimulates catabolism in C2C12 myotubes

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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)

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Ovarian cancer: pathology, biology, and disease models

Daniel G. Rosen et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2009)

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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

Valerie Risson et al.

JOURNAL OF CELL BIOLOGY (2009)

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Mechanisms of Cancer Cachexia

Michael J. Tisdale

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Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

C. Florian Bentzinger et al.

CELL METABOLISM (2008)

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Nuclear factor-kappa B signaling in skeletal muscle atrophy

Hong Li et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2008)

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FoxO3 controls autophagy in skeletal muscle in vivo

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CELL METABOLISM (2007)

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IGF-1 is downregulated in experimental cancer cachexia

Paola Costelli et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2006)

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Regulation of cancer cell migration and bone metastasis by RANKL

DH Jones et al.

NATURE (2006)

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Intraperitoneal cisplatin and paclitaxel in ovarian cancer

DK Armstrong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

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Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues - Association with cytokine expression, insulin resistance, and reduction by pioglitazone

GB Di Gregorio et al.

DIABETES (2005)

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IL-6-induced skeletal muscle atrophy

F Haddad et al.

JOURNAL OF APPLIED PHYSIOLOGY (2005)

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Cancer cachexia:: the molecular mechanisms

JM Argilés et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2003)

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Induction of cachexia in mice by systemically administered myostatin

TA Zimmers et al.

SCIENCE (2002)

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Cancer cachexia is mediated in part by the induction of IL-6-like cytokines from the spleen

BE Barton et al.

CYTOKINE (2001)

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Phase III trial of standard-dose intravenous cisplatin plus paclitaxel versus moderately high-dose carboplatin followed by intravenous paclitaxel and intraperitoneal cisplatin in small-volume stage III ovarian carcinoma: An intergroup study of the Gynecologic Oncology Group, Southwestern Oncology Group, and Eastern Cooperative Oncology Group

M Markman et al.

JOURNAL OF CLINICAL ONCOLOGY (2001)

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Randomized intergroup trial of cisplatin-paclitaxel versus cisplatin-cyclophosphamide in women with advanced epithelial ovarian cancer: Three-year results

MJ Piccart et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)

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