Total Syntheses of Brassicicenes A, R, and T

Here, we report concise and divergent total syntheses of fusicoccane members brassicicenes A, R, and T. The key feature of the synthesis is the rapid construction of the 5/8/5 tricyclic core via four steps: aldol reaction, Stork-Danheiser transposition, and ring-closing metathesis from known compounds followed by concise oxidation state adjustment.

Automated summary

In this study, concise and divergent total syntheses of fusicoccane members brassicicenes A, R, and T were reported. The key feature of the synthesis is the rapid construction of the 5/8/5 tricyclic core via four steps, followed by concise oxidation state adjustment.